Urbanization has brought with it large populations in cities, which has then led to changes in urban land use intensity and spatial patterns, resulting in changes in underlying surfaces and urban climate. The impacts of the early urbanization process and the rapid development of the international metropolis on the interactive development of spatial zoning, urban climate, and urbanization in the main region of Shanghai are studied. This study has important practical and methodological implications with respect to two major themes in the current urban planning area of China, specifically, the construction of new urbanization and the changes in urban climate adaptation. Through the experiences of the human activities model from ecology, factors are selected based on the effects of climate on four dimensions, namely, economy, urban construction, ecological, and environment, where the weight of each index is determined by the coefficient of the variation method and the important spatial factors influencing the climate effect are screened out. The four important influential factors are population density, road density, built-up areas, and the green coverage ratio of spatial distribution. A quantitative analysis determined that there exists a consistent relationship between urban climate factors and the four urbanization spatial factors. Based on urbanization classification that considered each factor evaluation along with integrated analyses and statistical correlation analyses of the spatial grid index using ArcGIS software, the urban space partition level is identified, and urban spatial zoning strategies based on the co-movement of urban climate system are put forward. Combined with the zoning study of land use and the urban heat island distribution pattern, the spatial zoning strategy of controlling urbanization intensity based on the urban climate system is proposed. This research will guide the integration of the urbanization spatial structure and urban climate system toward rational development in Shanghai city.