The Effect of Urinary Flow and Bladder Fullness on Renal Pelvic Pressure in a Rat Model

Smyth, Thomas B.; Shortliffe, Linda M. Dairiki; Constantinou, Christos E.

doi:10.1016/s0022-5347(17)37864-3

Cited by 27 publications

(11 citation statements)

References 18 publications

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“…The changes in pelvic pressure we have induced by pelvic perfusion are likely in the physiological range. Similar changes in pelvic pressure were observed during changes in urine flow rate caused by diuretic manoeuvres [16,22,231, during spontaneous contractions of the pelvis [24], and at different degrees of fullness of the urinary bladder [25]. In the rabbit, renal receptors capable of responding to changes in renal perfusion pressure or renal vein pressure, have already been described and defined as mechanoreceptors [5, 61.…”

Section: Discussionmentioning

confidence: 79%

Renal Afferents Responsive to Chemical and Mechanical Pelvic Stimuli in the Rabbit

et al. 1997

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1. Afferent nerve fibres sensitive to changes in the renal chemical environment have been found in the rat. To verify the existence of these fibres in the rabbit and their response pattern, afferent renal nerve activity was recorded during pelvic perfusions with NaCl solutions at different concentrations. 2. The experiments were carried out in 13 anaesthetized rabbits. Arterial pressure from a femoral catheter and afferent renal nerve activity from the distal stump of a cut renal nerve bundle were recorded. Three catheters were inserted into the renal pelvis to measure pelvic pressure, to allow pelvic perfusions at constant rates and to drain pelvic fluids. 3. After a control period, the pelvis was perfused with physiological saline (0.14 mol/l for 2 min), followed by one of a series of solutions containing increasing concentrations of NaCl (0.5, 0.75, 1.0 and 1.5 mol/l for 2 min). Pelvic perfusion was performed both at a low (0.2 ml/min) and a high (0.8 ml/min) flow rate for each solution tested. 4. In all animals arterial pressure was not modified during pelvic perfusions. Physiological saline did not change afferent renal nerve activity at the low perfusion rate, but it significantly increased afferent renal nerve activity and pelvic pressure at the high rate. Hypertonic NaCl solutions caused progressive increases in afferent renal nerve activity at both perfusion rates, and these effects were larger at the high perfusion rate. 5. These data demonstrate, in the rabbit, the existence of renal afferent nerves sensitive to discrete changes in pelvic ionic or osmotic concentration. The neural response is enhanced when renal mechano- and chemo-receptors are simultaneously activated.

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Section: Discussionmentioning

confidence: 79%

Renal Afferents Responsive to Chemical and Mechanical Pelvic Stimuli in the Rabbit

et al. 1997

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“…The experimental technique was as described previously by Smyth and colleagues, with modifications (6). The rabbits were anesthetized with an intramuscular injection of Zoletil (10 mg/kg).…”

Section: Methodsmentioning

confidence: 99%

Urodynamic and Histological Changes in a Sterile Rabbit Vesicoureteral Reflux Model

et al. 2010

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This study aimed to investigate pressure changes of renal pelvis and histological change of kidneys in a surgically induced sterile rabbit vesicoureteral reflux (VUR) model. Five rabbits served as a control group, 7 as the sham-operated group, and 8 served as the VUR group. Three weeks later, urodynamic studies were performed, and histological examinations evaluated degree of inflammation, fibrosis, and tubular damage in the kidneys. At a low infusion rate, renal pelvic pressure in the VUR group was stable until late filling phase and then increased slightly. At a high infusion rate, the renal pelvic pressures of the sham-operated and control groups were stable until late filling phase and then increased slightly, whereas the renal pelvic pressure in the VUR group steadily increased from mid filling phase. Focal thinning of the tubular epithelium and interstitial widening were observed in certain cortical areas of refluxing kidneys, without inflammatory cell infiltration. Obvious changes in the mean diameters of distal tubules and extracellular matrix volume fractions were observed in two highly refluxing kidneys. High pressure reflux with bladder instability may result in renal cortical changes.

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“…For urodynamic studies, the rats were anaesthetized with 30 mg/kg intraperitoneal pentobarbital and assessed as described previously [22,[26][27][28]. Briefly, rats were placed on a thermostatically controlled operating board and the body temperature maintained at 35-37 ∞ C, as measured by a left axillary subcutaneous temperature probe.…”

Section: Methodsmentioning

confidence: 99%

Structural changes in the bladder walls of pregnant and hormone‐treated rats: correlation with bladder dynamics

2004

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recorded during bladder filling and emptying. Connective tissue and smooth muscle were analysed morphometrically and quantitatively, and immunohistochemistry used to evaluate the distribution and expression of collagen types I, III and IV. RESULTSPG rats had significantly greater bladder compliance than NC, OO and PR rats ( P < 0.05). This correlated with the morphometric analysis, with bladders of PG and PR rats having lower connective tissue to smooth muscle ratios than NC, ES and OO rats ( P < 0.05). Collagen I was increased in the lamina propria of PG and ES rats, and the detrusor muscle layer showed greater localization of collagen III in the interfascicular space in the PG and PR rats than in the other groups. There was no change in the distribution of collagen IV. CONCLUSIONPG and PR rats had the highest bladder compliance and the changes paralleled structural changes in the bladders, specifically in the ratio of connective tissue to smooth muscle, and the distribution and expression of collagens I and III. These changes have agerelated implications in the urinary tract.

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The Effect of Urinary Flow and Bladder Fullness on Renal Pelvic Pressure in a Rat Model

Cited by 27 publications

References 18 publications

Renal Afferents Responsive to Chemical and Mechanical Pelvic Stimuli in the Rabbit

Renal Afferents Responsive to Chemical and Mechanical Pelvic Stimuli in the Rabbit

Urodynamic and Histological Changes in a Sterile Rabbit Vesicoureteral Reflux Model

Structural changes in the bladder walls of pregnant and hormone‐treated rats: correlation with bladder dynamics

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