The effect of uterine distension on the oestrous cycle of the guinea‐pig

Donovan, B. T.; Traczyk, W

doi:10.1113/jphysiol.1962.sp006883

Cited by 26 publications

(21 citation statements)

References 6 publications

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“…These are (a) the abrupt onset of the shrinkage seen in association with distension of the uterus, (b) the timing of this change at 8-10 days and (c) the existence of a unilateral effect. Removal of newly formed corpora lutea from the ovaries of the guinea-pig causes the re-appearance of oestrus after about 11 days (Loeb, 1911;Dempsey, 1937) and the present work, as well as that of Donovan & Traczyk (1960, 1962 and Moore (1961), has shown that distension of the uterus results in cycles of approximately that length.…”

Section: Discussionmentioning

confidence: 84%

“…The glass beads were of the same type as used in the previous study (Donovan & Traczyk, 1960, 1962 and were made from 7 mm lengths of 3 mm diameter glass tubing. During preparation of the beads a short length of platinum wire was fused into the glass in order to aid radiographic localization.…”

Section: Methodsmentioning

confidence: 99%

“…After at least one control cycle, glass beads were inserted into the lumen of the uterus through an incision in the cervical region, as described by Donovan & Traczyk (1962). In order to prevent the extrusion of the beads through the cervix a loose snare of platinum wire was placed around the base of each uterine horn and so adjusted as to avoid constriction of the uterine lumen while barring passage of the beads.…”

Section: Methodsmentioning

confidence: 99%

“…The oestrous cycle of this species is also shortened from 16 days to about 11 days by the surgical removal of the corpora lutea from the ovaries (Loeb, 1911;Dempsey, 1937) and it was therefore suggested that the beads might alter the cycle length by curtailing the functional life of the luteal bodies (Donovan & Traczyk, 1962). This view is supported by the results of the present work in which the effect on the corpora lutea of differing numbers of beads located in one or both horns of the uterus has been examined, and the existence of a local effect causing regression of the corpora lutea in the ovary associated with the distended horn established.…”

Section: Introductionmentioning

confidence: 99%

“…For the guinea-pig, Donovan & Traczyk (1960, 1962 showed that when two glass beads were present in each horn of the uterus the oestrous cycle was reduced from a normal span of 16 days to 12 or 13 days. The oestrous cycle of this species is also shortened from 16 days to about 11 days by the surgical removal of the corpora lutea from the ovaries (Loeb, 1911;Dempsey, 1937) and it was therefore suggested that the beads might alter the cycle length by curtailing the functional life of the luteal bodies (Donovan & Traczyk, 1962).…”

Section: Introductionmentioning

confidence: 99%

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Uterine distension and the function of the corpora lutea in the guinea‐pig

Bland¹,

Donovan²

1966

The Journal of Physiology

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1. The presence of two glass beads (7 × 3 mm) in each horn of the uterus was associated with a reduction of 3‐4 days in the length of the oestrous cycle. 2. Two beads inserted into each uterine horn between days 2 and 4 exerted a greater effect on the oestrous cycle than either one bead in each horn or four beads in one horn only. Two beads located in one horn failed to affect cycle length. 3. Measurement of the volume of the corpora lutea showed that distension of the uterus induced a premature regression in the size of the luteal bodies. 4. When glass beads were present in one uterine horn, early and unilateral regression of the corpora lutea in the ovary adjacent to the distended horn was observed. Regression of the corpora lutea in the opposite ovary proceeded normally. 5. In view of the local effect of uterine distension and other information, it is concluded that each uterine horn can produce a luteolytic substance which is conveyed to the neighbouring ovary to act upon the corpora lutea.

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Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Uterine distension and the function of the corpora lutea in the guinea‐pig

Bland¹,

Donovan²

1966

The Journal of Physiology

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Local uterine regulation of the corpus luteum

Fischer

1967

Am. J. Anat.

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In order to determine if the well known uterine inhibition of the guinea pig corpus luteum is a local effect, a series of partial hysterectomies were performed. Some groups were subjected to one-half or three-fourths hysterectomies alone, while in others one ovary was also removed on either the side retaining some or the side losing all uterine tissue. In addition, two groups in which all ovarian and uterine tissue was preserved were subjected to unilateral or bilateral complete surgical separation of all communicating structures between uterus and ovary. Sham-operated, totally hysterectomized, and unilaterally ovariectomized groups were used as controls.In all groups in which an ovary left in the animal was separated from direct contact with its uterine horn, the estrous cycles became long and erratic, or were arrested completely due to the persistance of active corpora lutea in those ovaries. However, corpora lutea regressed normally in all ovaries left in their normal relationship to a uterine horn. These results indicate that the uterine regulatory factor does reach the ovary by some local route.The mammalian uterus has, since ancient times, been known as the organ in which the young undergo embryonic development, yet only within the last 45 years has it been suspected of playing a more subtle role in the physiology of reproduction. Experiments conducted by Loeb (' 23, '27) upon the guinea pig demonstrated that, in at least this one form, the uterus is capable of contributing to the regular cyclic rhythmicity of the ovary by periodically curtailing the functional life of the corpus luteum. Loeb found that removal of the uterus a few days after estrus resulted in a sudden and complete cessation of all cyclic activity for a period much longer than the normal duration of pregnancy. The corpora lutea in these anestrous animals were evidently in a state of high activity; they were larger than those of pregnancy, and were composed of large polygonal cells, many of which were in mitosis.Histological examination of the vagina and mammary glands gave additional evidence that the corpora lutea were actively secreting progesterone. Since Loeb's work, this phenomenon in the guinea pig has been amply confirmed by many others, and has been proven to exist in other mammals. In all cases where hysterectomy provokes a disruption of the sexual cycle, the corpus luteum is maintained in an apparently functional state. AM. J. ANAT., 121: 425-442.Loeb's experiments quickly stimulated interest in the field of utero-ovarian relationships. Studies were made of many different mammals to determine whether the effect of hysterectomy was of a more general occurrence. In recent years, it has also been found that distension of the uterus results in the opposite phenomenon, the early regression of corpora lutea and concomitant shortening of the estrous cycle (Moore and Nalbandov, '53). The results of the various types of experiments performed during these years fall into three main groups. No apparent uterine influence onthe ovary ...

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Biosynthesis and Function of Eicosanoids in the Uterus

Chaudhuri

1990

Uterine Function

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The effect of uterine distension on the oestrous cycle of the guinea‐pig

Cited by 26 publications

References 6 publications

Uterine distension and the function of the corpora lutea in the guinea‐pig

Uterine distension and the function of the corpora lutea in the guinea‐pig

Local uterine regulation of the corpus luteum

Biosynthesis and Function of Eicosanoids in the Uterus

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