The Effect of Vagotomy on Gastrin-Stimulated Gastric-Acid Secretion in Man

Barabas, A. P.; Payne, Robert A.; Johnston, Ian; Burns, G.P.

doi:10.1016/s0140-6736(66)91258-x

Cited by 34 publications

(9 citation statements)

References 7 publications

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“…With respect both to the shape of the dose-response curve to gastrin (EmAs et al, 1967a) and to the effect of a rapid injection of a large dose of gastrin on acid secretion our findings on cats differ from those on dogs but are in agreement with those reported on man (Barabas et al, 1966;Makhlouf, et al, 1966). The present study offers no explanation for the inhibitory action of gastrin on acid secretion in dogs.…”

Section: Discussionsupporting

confidence: 83%

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Difference in responses between dogs and cats to large doses of gastrin on gastric secretion.

Emås¹,

Grossman²

1967

Gut

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EDITORIAL COMMENT In dogs the rapid injection of gastrin causes marked inhibition of induced acid secretion, but in cats there was increased secretion as occurs in man. This reaction in cats was abolished by truncal vagotomy.We (EmAs and Grossman, 1967a) recently reported that in conscious dogs supramaximal doses of gastrin extract caused a downward inflection in the doseresponse curve for acid secretion whereas in conscious cats maximal and supramaximal doses were equally effective, resulting in a plateau of the doseresponse curve. Our finding in cats agreed with that reported in man (Barabas, Payne, Johnston, and Burns, 1966). The inflection of the dose-response curve in dogs could be due to the inhibitory effect of large doses of gastrin on acid secretion that has been demonstrated in this species Gregory and Tracy, 1964;Konturek and Grossman, 1965). Conversely, the absence of the inflection of the dose-response curve in cats could indicate that large doses of gastrin in cats, as in man (Makhlouf, McManus, and Card, 1966), do not inhibit acid secretion.The present study was designed to determine if a species difference exists between conscious dogs and cats in the effect of a rapid injection of a large dose of gastrin extract on acid and pepsin secretion. The results prompted us to repeat the study after truncal vagotomy. METHODSIn four adult mongrel dogs (11.6 to 15.0 kg., mean 13.3 kg.) and four cats (3.2 to 4.8 kg., mean 3.8 kg.) gastric cannulas were inserted just proximal to the pyloric gland area near the greater curvature. The type of cannula used in the dogs was described by Thomas (1941) and that in the cats by one of us (Emas, 1960). Secretory studies were started three weeks after surgery.After the conclusion of the first series of studies bilateral truncal vagotomy was performed under artificial respiration through an incision between the seventh and eighth left rib. Two or 3 cm. of each trunk was resected. Following the vagotomy three of four cats accumulated balls of hair in the stomach. The hair was removed through a gastrotomy and a pyloroplasty was performed as described previously (Emis, 1964

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Section: Discussionsupporting

confidence: 83%

“…Our finding in cats agreed with that reported in man (Barabas, Payne, Johnston, and Burns, 1966). The inflection of the dose-response curve in dogs could be due to the inhibitory effect of large doses of gastrin on acid secretion that has been demonstrated in this species Gregory and Tracy, 1964;Konturek and Grossman, 1965).…”

supporting

confidence: 92%

Difference in responses between dogs and cats to large doses of gastrin on gastric secretion.

Emås¹,

Grossman²

1967

Gut

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“…The response to gastrin was significantly lower than that to histamine (P < 0.01, Wilcoxon pairdifferences test). It may be mentioned in passing that this difference does not appear if dogs with gastric fistulas are studied (Passaro & Grossman 1964); nor is it found, apparently, in experiments on man (Makhlouf et al 1964, Barabas et al 1966). The possible reasons for this difference between experiments with pouches and fistulas need not be discussed as they have no bearing on our main conclusion.…”

Section: Discussionmentioning

confidence: 97%

“…In the hope of finding a method for forecasting the result of vagotomy, hundreds of clinical tests have been made to study the blocking action of combinations of hexamethonium and atropine (McArthur et al 1960, Gillespie & Kay 1961, Johnston et al 1966. The theoretical basis of such tests has never been investigated.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vagal Block or Hexamethonium on Gastric Secretion in the Dog

Limbosch

Wyllie

Nyhus

1968

Scandinavian Journal of Gastroenterology

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LIMBOSCH, J.-M., WYLLIE, J. H. & NYHUS, LLOYD M. The Effect of Vagal Block or Hexamethonium on Gastric Secretion in the Dog. Scand. J . Gasfroent. 3,7-17, 1968.Because of relevance to the operation of vagotomy in man, and to 'medical vagotomy' tests attempting to forecast the results of surgery, we have made a study in the dog of the effects of (1) blocking the vagus nerves with local anaesthetic and (2) injecting intravenously a ganglion-blocking drug. Gastric secretion was stimulated with both high and low doses of histamine and gastrin in dogs equipped with either a Heidenhain or a Pavlov pouch. Although the blocking procedures abolished acid and pepsin secretion caused by a pure vagal stimulant (2-deoxy-D-glucose) they had less effect against gastrin, and still less against histamine. The implications of these results are discussed. . (1966) Medical vagotomy; an assessment. Brit. med. J. 11, KOMAROV, S. A. (1942) Studies on gastrin: Physiological properties of the specific gastric secretagogue of the pyloric mucous membrane. Rev. Canad. Eiol. 1, 595-598. 463-471.Scand J Gastroenterol Downloaded from informahealthcare.com by University of Sydney on 01/03/15For personal use only.

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“…There are many studies on the influence ofvagal transection (Waddell, 1957;Gillespie, Clark, Kay, and Tankel, 1960;Bachrach, 1962;Bell, 1964;Gelb, Baronofsky, and Janowitz, 1961; Barabas, Payne, Johnstone, and Burns, 1966;Bank, Marks, and Louw, 1967) and vagal block with drugs, 'medical vagotomy', (McArthur, Tankel, and Kay, 1960;Gillespie and Kay, 1961;Checketts, Gillespie, and Kay, 1966) upon gastric acid secretion in duodenal ulcer patients. Such data for normal healthy persons are not available.…”

mentioning

confidence: 99%