The Effect of Varying Inspiratory Gas Flow Rate on Arterial Oxygenation During Ippv in the Respiratory Distress Syndrome

Owen-Thomas, J.B.; Ulan, O. A.; Swyer, Paul R.

doi:10.1093/bja/40.7.493

Cited by 33 publications

(12 citation statements)

References 9 publications

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“…The previously reported tendency for individual infants to respond to a different degree to changes in specific parameters of ventilation at different ages [16] is also apparent in our study ( figs. 1-6) ; however, the average magnitude of change in PaO, was greater in our infants than in those reported by OWEN-THOMAS <t al.…”

Section: Resultssupporting

confidence: 89%

“…One infant (F.U.) has had slowly clearing change occurring as a result of specific variation of clinical and radiological lung disease, and one infant individual parameters of ventilation [16]. In that in-(R.O.)…”

Section: Resultsmentioning

confidence: 99%

“…1-6) ; however, the average magnitude of change in PaO, was greater in our infants than in those reported by OWEN-THOMAS <t al. [16].…”

Section: Resultsmentioning

confidence: 99%

“…Arterial oxygen content (CaO,) was determined by adding dissolved oxygen (PaO, x 0.003 1) to CHbO,. In some instances, total 'physiologic' right to left shunt was calculated according to the method of OWEN-THOMAS et al [16].…”

Section: Estimation Of Arterial Oxygen Conlentmentioning

confidence: 99%

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Mechanical Ventilation of Newborn Infants I. The Effect of Rate and Pressure on Arterial Oxygenation of Infants with Respiratory Distress Syndrome

et al. 1969

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ExtractThis study reports the effect of varying specific parameters of mechanical ventilation on aortic PO, in six infants with severe respiratory distress syndrome. Twenty-seven studies were performed during the first 168 hours of mechanical ventilation. I n each study, arterial oxygen partial pressure was found to vary directly with airway pressure a n d inversely with respiratory rate. No correlation was found between rate and pressure, or PaO,, PaCO,, a n d p H a . Oxygenation of infants with severe respiratory distress syndrome can be significantly influenced by variation of specific parameters of mechanical ventilation independently of change in aortic carbon dioxide tension.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

“…1-6) ; however, the average magnitude of change in PaO, was greater in our infants than in those reported by OWEN-THOMAS <t al. [16].…”

Section: Resultsmentioning

confidence: 99%

Section: Estimation Of Arterial Oxygen Conlentmentioning

confidence: 99%

See 2 more Smart Citations

Mechanical Ventilation of Newborn Infants I. The Effect of Rate and Pressure on Arterial Oxygenation of Infants with Respiratory Distress Syndrome

et al. 1969

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“…Blood pH and PC,, were determined with a p H and blood gas analyzer (25) and the base excess computed from a SiggaardAndersen chart (31). Calcium ion activity in the plasma was determined under anaerobic conditions with a C a + + flow-through system and digital pH meter (27).…”

Section: Chemical Methodsmentioning

confidence: 99%

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

et al. 1975

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Mortality and Morbidity Associated With Pressure- and Volume-Limited Infant Ventilators

Boros¹

1978

Arch Pediatr Adolesc Med

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\s=b\ The effect of pressure-limited (PL) and volume-limited (VL) ventilation on mortality and morbidity in infants with severe hyaline membrane disease (HMD) was examined in a prospective controlled study. Criteria for mechanical ventilation were Pao2 value of 50 mm Hg or less or a Paco2value of 70 mm Hg or greater, while the infant was receiving nasal continuous positive airway pressure (CPAP) at oxygen concentrations (FIO2) of 0.8 or greater and CPAP of 8 cm H2O or greater; HMD associated with severe perinatal asphyxia requiring mechanical ventilation in the delivery room.Consecutive patients were alternately assigned to receive either PL or VL ventilation. Twenty infants were ventilated with PL machines using low peak inspiratory pressures (mean maximum inspiratory pressure of 28 cm H2O) and prolonged inspiratory times. Twenty other infants were ventilated with VL machines, using essentially unlimited peak inspiratory pressures (mean maximum inspiratory pressure of 62 cm H2O) and prolonged expiratory times.There were no significant differences in survival, incidence of pneumothorax or pulmonary interstitial emphysema, or noteworthy bronchopulmonary dysplasia.(Am J Dis Child 132: [865][866][867][868][869] 1978) The relative merits and shortcom¬ ings of pressure-limited (PL) andvolume-limited (VL) ventilation in infants have been, and continue to be, controversial topics. The simplicity of the PL ventilator, its compact size, and its ability to compensate for air leaks within the system are given attributes. The VL ventilator's versa¬ tility, variable inspiratory flow rate, and ability to compensate for ongoing changes in lung compliance are known advantages. When used strictly as a constant tidal volume machine, the VL ventilator is essentially pressureunlimited.Recent clinical investigations impli¬ cating excessive airway pressure as an important factor in the development of bronchopulmonary dysplasia (BPD) have raised serious questions about the advisability of using VL ventila¬ tors.1·-In an attempt to resolve some of these questions, a controlled venti¬ lator trial was carried out. Neonates with severe hyaline membrane dis¬ ease (HMD) who required mechanical ventilation were alternately assigned From the Children'

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The Effect of Varying Inspiratory Gas Flow Rate on Arterial Oxygenation During Ippv in the Respiratory Distress Syndrome

Cited by 33 publications

References 9 publications

Mechanical Ventilation of Newborn Infants I. The Effect of Rate and Pressure on Arterial Oxygenation of Infants with Respiratory Distress Syndrome

Mechanical Ventilation of Newborn Infants I. The Effect of Rate and Pressure on Arterial Oxygenation of Infants with Respiratory Distress Syndrome

Growth and Mineral Metabolism in Very Low Birth Weight Infants. II. Effects of Calcium Supplementation on Growth and Divalent Cations

Mortality and Morbidity Associated With Pressure- and Volume-Limited Infant Ventilators

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