The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats

Doğan, Muhammed Fatih; Kaya, Kürşat; Demirel, Hasan Hüseyin; Başeğmez, Mehmet; Şahi̇n, Yasemin; Çiftçi, Osman

doi:10.1080/08923973.2023.2181712

Cited by 9 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, increased prooxidant system activity and deterioration of the antioxidant system (Table 3) result in oxidative stress. The development of many chronic diseases, including diabetes [30], cancer [31], antiviral agents [32], and various agingrelated and central nervous system (CNS) disorders [33], can result in high levels of reactive oxygen and nitrogen species production. In addition, reactive oxygen Table 1.…”

Section: The Role Of Selenium In Oxidative Stress Inflammation and Im...mentioning

confidence: 99%

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Başeğmez¹

2023

Selenium and Human Health

Self Cite

View full text Add to dashboard Cite

Selenium, whose name comes from the Greek word for “Selene,” has been a topic of interest as a micronutrient ever since it was described in 1817 as a by-product of sulfuric acid manufacturing. Selenium, the most important micronutrient for both humans and animals, must be consumed daily to support the body’s natural metabolism and homeostasis. The small intestine is responsible for the absorption of selenium in both its organic and inorganic forms. Selenium is then able to be widely distributed throughout the body’s diverse tissues, where it plays an important role in the regulation of the synthesis of selenoproteins. The synthesis of human selenoproteins involves the incorporation of a selenium-containing homolog of cysteine in each of the 25 selenium-containing proteins that make up this series. Many selenoproteins, including glutathione peroxidase (GPX), thioredoxin reductase (TrxR), and iodothyronine deiodinases (IDD), function as crucial cellular defenses against oxidative stress. Therefore, selenium is extremely important in boosting antioxidant defense. Recent studies have also shown that there is a close relationship between selenium and inflammation, and that selenium has regulatory effects on inflammation by affecting the expression of various cytokines. This chapter’s goal was to thoroughly review the research on how selenium is related to antioxidant and anti-inflammatory activity.

show abstract

Section: The Role Of Selenium In Oxidative Stress Inflammation and Im...mentioning

confidence: 99%

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Başeğmez¹

2023

Selenium and Human Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mechanistically, both physiologically generated ROS and reactive nitrogen species are scavenged by Vit C [18]. Indeed, Vit C increases the activity of cellular anti-oxidant factors and reduces the generation of lipid peroxidation in different organs to inhibit their damage by ROS [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach

Khezri,

Varzandeh,

Ghasemnejad-Berenji

2024

Drug Res (Stuttg)

View full text Add to dashboard Cite

Introduction Gastric ulcer is one of the most common and serious conditions in the gastrointestinal tract. One of the main causes of gastric ulcers is using of non-steroidal anti-inflammatory drugs (NSAIDs) which have limited their use in clinical practice. Several studies have revealed that metformin and Vitamin C (Vit C) exhibit protective effects against gastric mucosal damage in different animal models. However, no studies indicate their combination's effect on gastric ulcer models. Therefore, this study aims to investigate the protective effects of metformin and Vit C combination on indomethacin-induced gastric ulcers. Material and methods In total, thirty rats were divided into six groups, including the control group, rats received indomethacin (50 mg/kg, i.p.), rats received indomethacin and pretreated with ranitidine (100 mg/kg), metformin (100 mg/kg, i.p.), Vit C (100 mg/kg), or metformin combined with Vit C. Four hours after indomethacin administration, rats were euthanized, and gastric tissues were removed for macroscopic, histopathologic, and biochemical examinations. Results All therapeutics used in this study were found to alleviate gastric mucosal injury caused by indomethacin, as observed in histopathologic and macroscopic evaluations. Both Vit C and metformin were observed to significantly decrease lipid peroxidation and enhance the activity of anti-oxidative enzymes, SOD, GPx, and catalase. However, a more significant effectiveness was observed in catalase and GPx activities when Vit C was co-administered with metformin. Conclusions In conclusion, the present study revealed that metformin and Vit C combination therapy could potentially treat gastric ulcers associated with indomethacin.

show abstract

“…When the oxidative-antioxidant balance function is disrupted as a result of oxidative stress, several pathogenic processes can occur in vascular system. Oxidative stress and the formation of reactive oxygen species (ROS) contribute to the progression of tissue injury by activating the inflammatory response via the release of proinflammatory cytokines and the accumulation of inflammatory cells in tissues [6]. Endothelial dysfunction is important in the development of vascular diseases, and selenium reduces endothelial damage and prevents disruption of endothelial-dependent relaxation [7].…”

Section: Introductionmentioning

confidence: 99%

Vascular System: Role of Selenium in Vascular Diseases

Doğan¹

2023

Selenium and Human Health

View full text Add to dashboard Cite

The trace element selenium is crucial for cellular defense against oxidative stress and inflammatory reactions. Balanced selenium levels are important for the vascular system, whereas dysregulation can damage vascular reactivity. Reports have also supported the strong relationship between oxidative stress and vascular inflammation, which are induced by either the overproduction of reactive oxygen species (ROS) or the lack of antioxidant defense proteins. The damage of vascular smooth muscle and endothelium layer are frequently linked to vascular disorders such as hypertension, hypercholesterolemia, and atherosclerosis. Vascular diseases can result in life-threatening serious cardiovascular complications, such as blood clots, heart attack, and stroke. Selenium levels are crucial for preventing vascular damage; however, either low or extremely high amounts of selenium intake may contribute to the pathophysiology of vascular disorders. Selenoproteins are proteins such as glutathione peroxidase containing selenium in the form of the 21st amino acid, selenocysteine. Selenoproteins have the capacity to protect vascular smooth muscle and endothelium by lowering harmful ROS, which allows them to regulate normal vascular functions including vasoreactivity. The current chapter’s goal was to carry out a thorough evaluation of the literature on the connection between selenium and vascular disorders.

show abstract

The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats

Cited by 9 publications

References 37 publications

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

An Overview of the Antioxidant and Anti-Inflammatory Activity of Selenium

Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach

Vascular System: Role of Selenium in Vascular Diseases

Contact Info

Product

Resources

About