The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial

Abstract

Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a 3-year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.

Association of Vitamin K Status Combined With Vitamin D Status and Lower‐Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts

“…Vitamin D status has been well-studied in relation to knee OA and related lower-extremity function and pain observationally, with conflicting results (32;33). Three of the four randomized placebo-controlled trials of OA patients did not find any consistent benefit of vitamin D supplementation by itself on knee pain or structural knee OA progression (6–9), indicating vitamin D supplementation alone is not likely to reduce OA progression or improve the functional consequences of knee OA. Compared to healthy individuals, knee OA patients have worse lower-extremity function, including slower gait speed (34;35).…”

“…Several clinical trials have tested the effect of vitamin D supplementation on knee OA and overall the results did not support a role for vitamin D supplementation by itself in improving knee OA symptoms or structural outcomes (6–9). Higher vitamin K status has been associated with less knee OA progression and better lower-extremity function observationally (10–12), but vitamin K supplementation has not been tested in knee OA clinical trials.…”

Витамин D И Остеоартроз

“…Добавка вітаміну D при-зводила у 80 % хворих до підвищення рівня 25(ОН)D на 10 мкг/л за рік порівняно з плацебо, проте не ви-явлено уповільнення звуження суглобової щілини, зменшення болю або підвищення функціональних по-казників [59]. Можливо, доза кальциферолу (800 МО) була низькою.…”

Dietary Supplements for Treating Osteoarthritis: a Systematic Review and Meta-analysis

“…[35][36][37] Glucosamine (n=18 trials) and chondroitin (n=14 trials) were the most frequently investigated supplements, whereas eight supplements were investigated by only one trial. Fifty-eight of the 69 included trials (84%) investigated knee, five (7%) studied hip and knee, four (6%) assessed hip and two (3%) included hand OA.…”