The effect of vitamin D3 and paricalcitol on penicillin-induced epileptiform activity in rats

Sümbül, Orhan; Aygün, Hatice

doi:10.1016/j.eplepsyres.2019.106262

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…As a classical epileptogenic agent, penicillin is widely used in the establishment of animal models of epilepsy [ 116 ]. Sumbul and Aygun et al have reported that the microinjection of penicillin into the sensorimotor cortex induced epileptiform activity in rats [ 117 ]. Additionally, the injection of penicillin into the hippocampus has established TLE models in macaques [ 118 ].…”

Section: Temporal Lobe Epilepsy Modelsmentioning

confidence: 99%

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Animal Models of Epilepsy: A Phenotype-oriented Review

Wang¹,

Wei²,

Feng³

et al. 2022

Aging and disease

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Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious damage to brain function, which is usually observed in patients with temporal lobe epilepsy. Controlling seizure attacks is vital for the treatment and prognosis of epilepsy. Animal models, such as the kindling model, which was the most widely used model in the past, allow the understanding of the potential epileptogenic mechanisms and selection of antiepileptic drugs. In recent years, various animal models of epilepsy have been established to mimic different seizure types, without clear merits and demerits. Accordingly, this review provides a summary of the views mentioned above, aiming to provide a reference for animal model selection.

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Section: Temporal Lobe Epilepsy Modelsmentioning

confidence: 99%

“…Repeated injections are required for seizure attacks. Additionally, the simple mechanism involved in the model cannot mimic the complicated mechanism of humans [ 117 , 118 ].…”

Section: Temporal Lobe Epilepsy Modelsmentioning

confidence: 99%

Animal Models of Epilepsy: A Phenotype-oriented Review

Wang¹,

Wei²,

Feng³

et al. 2022

Aging and disease

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show abstract

“…The first electrode was placed in a position 3 mm lateral to sagittal suture and 4 mm anterior to bregma, while the second one was mounted in a position 3 mm lateral to sagittal suture and 4 mm posterior to bregma. A third electrode was used as a reference and implanted in the skin [7]. The ECoG activity was monitored online using a PowerLab 4/25 (AD Instruments, Australia) data acquisition system (Figure 1).…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The penicillin-epilepsy model has been commonly used in experimental animal studies to research the neuronal basis of epilepsy. Seizures are induced in a generalized fashion by the intracortical, intracerebroventricular, or intraperitoneal administration of penicillin, a GABA receptor antagonist, on the experimental animals [7][8][9]. There is no study in the literature on the roles of proinflammatory cytokines in the penicillin rat model of epilepsy.…”

Section: Introductionmentioning

confidence: 99%

The effect of penicillin-induced epileptiform activity on proinflammatory cytokines levels in the rat brain

Filiz

Karabulut

2021

Cumhuriyet Science Journal

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Emerging evidence indicates a pathogenic role of protracted neuroinflammation in the various neurodegenerative diseases, including epilepsy. Neuroinflammation may contribute to neuronal hyperexcitability underlying seizure formation. The current research aims to examine the changes in the levels of proinflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the penicillin epilepsy model. In the present study, 12 male Wistar albino rats were randomly divided into two groups as sham and penicillin epilepsy model. Seizures were induced with the intracortical (i.c.) single microinjection 500 IU of penicillin-G into neocortex. Rats were decapitated after observing the cortical epileptic activity and brains were removed by craniotomy. Proinflammatory cytokines (TNF-α and IL-1β) were measured by using ELISA methods in the cortical and hippocampal brain regions. Penicillin significantly up-regulated the expression of IL-1β and TNF-α in the rat cortex, but did not affect the hippocampal cytokines levels. This study is indicative of the neuroinflammatory potential of cortical penicillin administration.

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Micronutrients and Epilepsy

Arulsamy

Shaikh

2022

Nutritional Neurosciences

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The effect of vitamin D3 and paricalcitol on penicillin-induced epileptiform activity in rats

Cited by 7 publications

References 56 publications

Animal Models of Epilepsy: A Phenotype-oriented Review

Animal Models of Epilepsy: A Phenotype-oriented Review

The effect of penicillin-induced epileptiform activity on proinflammatory cytokines levels in the rat brain

Micronutrients and Epilepsy

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