The Effect of Water Extracts of Phyllanthus emblica and Costus speciousus on Reducing Obesity in Albino Rats

Abstract

Bakground: Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health, leading to reduced life expectancy and/or increased health problems. Obesity increases the likelihood of various diseases, particularly heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis.Obesity is most commonly caused by a combination of excessive food energy intake, lack of physical activity, and genetic susceptibility, endocrine disorders, medications, or psychiatric illness. Objective: This work aimed to study the effect of phyllanthus and costus aqueous extracts on inflicted obese rats. Materials and methods: Thirty mature male albino rats weighing 150±5g were divided into 6 equal groups (n=5 rats each); one group was kept as a negative control, while the other 5 groups were fed for four weaks on high fat diet ( 40 % of calories as fat) to induce obesity, one group of them was left as positive control group (C +ve) while the rest four groups were given orally two doses(300 and 600 mg/kg) of phyllanthus and costus aqueous extracts. At the end of experimental period (28 days), blood samples were collected for serum separation to determine serum level glucose, Apolipoprotin B, liver enzymes (AST, ALT and ALP), total cholesterol, triglycerides, atherosclerosis index, lipoprotein fraction (HDLc, LDLc and VLDLc), kidney function(creatinine, urea and uric acid) and histopathological examination for the liver and heart. Results: The obtained results demonstrated that phyllanthus and costus aqueous extracts caused significant improvement in seurum glucose ,liver enzymes, lipid profile, apolipoprotienA and kidney functions in inflicted obese rats. Conclusion: According to the results obtained, phyllanthus and costus aqueous extracts could be used for obese treatment and to improve vital functions of the body and weight loss.

Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis

“…On the other hand, our results revealed that SCREE supplementation with NaNO2 has significant and dose-dependent improvements in body weight, body weight gain, and liver weight, while it exhibits insignificant effects on kidney weight compared to the control group. The improvement observed by SCREE treatment is consistent with the studies by abdul-hussein (2019) and Ahmed (Ahmed, 2017) that showed that rats given ethanolic extract of S. costus exhibit significantly (p < 0.05) higher final BW and BWG values compared to the control group. Thyroid hormones play an essential role in growth, development, reproduction, and stress response (Peter, 2011).…”