The effect of wound complications following mastectomy with immediate reconstruction on breast cancer recurrence

Valente, Stephanie A.; Liu, Yitian; Upadhyaya, Siddhi N; Tu, Chao; Pratt, Debra A.

doi:10.1016/j.amjsurg.2018.10.028

Cited by 18 publications

(47 citation statements)

References 12 publications

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“…After excluding animal studies, non-English manuscripts and duplicates, 9874 manuscript titles were screened for relevance. Forty-six studies were evaluated using full text for eligibility according to criteria, and a final 10 papers were included in the final review [33][34][35][36][39][40][41][42][43][44]. A summary of these studies is shown in tables 1-6.…”

Section: Resultsmentioning

confidence: 99%

The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis

Savioli

Edwards

McMillan

et al. 2020

Critical Reviews in Oncology/Hematology

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Background: This systematic review investigated the impact of complications on long term outcomes for patients with primary invasive operable breast cancer.Methods: A systematic review was performed using appropriate keywords, and meta-analysis using a random effects model completed.Results: Ten retrospective cohort studies, including 37657 patients were included. Five studies identified a relationship between wound complications, infection and pyrexia and recurrence or recurrence-free survival. Risk of recurrence, 1-year and 5-year recurrence-free survival and overall survival were related to complications, particularly for patients with poor Nottingham Prognostic Index. Five studies failed to demonstrate a relationship between complications and prognosis. Complication was found to significantly affect 5-year recurrence-free survival (HR 1.48 95% CI 1.02-2.14, p=0.04) but not recurrence (HR 2.39, 95%CI 0.94-6.07, p=0.07), with a high degree of heterogeneity among analysed studies (I2=95%).Discussion: Further research is needed to quantify the effects of postoperative complication on prognosis following surgery for breast cancer.

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Section: Resultsmentioning

confidence: 99%

The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis

Savioli

Edwards

McMillan

et al. 2020

Critical Reviews in Oncology/Hematology

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“…Following the baseline testing, participants were randomly allocated to one of three groups: high intensity interval training (HIIT); continuous moderate intensity training (CMIT); or control (CON). A concealed, computer generated sequence of numbers in blocks of variable sizes [ 3 , 6 , 9 ] in a 1:1:1 ratio for the three intervention groups stratified by age (< 60 years and ≥ 60 years) was generated by a researcher not involved (blinded) in the study. After baseline testing a sealed envelope with the group allocation was given to the participant.…”

Section: Methodsmentioning

confidence: 99%

“…The World Health Organization (WHO) reported 2.08 million cases of breast cancer worldwide in 2019, a major contributor to the global burden of disease [ 6 ]. Women diagnosed with breast cancer often experience complications after surgery such as breast cancer related lymphoedema, axillary web syndrome, and cancer-related fatigue [ 7 – 9 ]. They also commonly suffer from long term treatment related side effects such as peripheral neuropathies and reduced quality of life [ 7 , 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

et al. 2020

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Background Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors. Methods Participants were randomly assigned to; 1) high intensity interval training (HIIT); 2) moderate-intensity, continuous aerobic training (CMIT); or 3) a wait-list control (CON) for a 12-week (36 session) stationary cycling intervention. Cardiorespiratory fitness (VO 2peak ), resting HRV and salivary biomarkers were measured at baseline 2–4 d pre-intervention and 2–4 d post the last exercise session. Results Seventeen participants were included in this study (62 ± 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement ( p ≤ 0.05) was observed for VO 2peak in the HIIT group; 19.3% (B = 3.98, 95%CI = [1.89; 4.02]) and a non-significant increase in the CMIT group; 5.6% (B = 1.96, 95%CI = [− 0.11; 4.03]), compared with a 2.6% (B = − 0.64, 95%CI = [− 2.10; 0.82]) decrease in the CON group. Post intervention improvements in HRV markers of vagal activity (log (ln)LF/HF, LnRMSSD) and sympathetic nervous system (α-amylase waking response) occurred for individuals exhibiting outlying (> 95% CI) levels at baseline compared to general population. Conclusion High intensity interval training improved cardiovascular fitness in breast cancer survivors and improved cardiac regulation, and sympathetic nervous system (stress) responses in some individuals. High-intensity interval training was safe and effective for breast cancer survivors to participate in with promising results as a time efficient intensity to improve physical health and stress, reducing CVD risk. Trial registration This pilot study was retrospectively registered through the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000684921 .

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“…In a study evaluating surgical and patient-reported outcomes and quality of life in patients with autologous breast reconstruction after failed implant-based reconstruction, there was a statistically significant increase in overall outcomes (p < 0.001), satisfaction with appearance of breasts (p < 0.001), psychosocial well-being (p < 0.001), and physical well-being of the chest (p = 0.003) [45]. Complication rate for MLDF is reported much lower and generally include seroma formation, hematoma, flap necrosis, loss of flap, and wound infection [12,47]. In our study, our complication rate was 17% in group 1 and 23% in group 2.…”

Section: Discussionmentioning

confidence: 99%

“…In spite of these statistically higher rate of poor prognostic factors in PM + MLDF group, no differences were seen between the groups in terms of 5-year local recurrence (2% and 3%) and overall survival rates (97% in both groups). Prosthetic-based breast reconstruction was associated with increased major breast complications up to 49% [44][45][46][47][48][49]. It is expensive and results in delays for adjuvant systemic treatment.…”

Section: Discussionmentioning

confidence: 99%

Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M + I) regarding quality of life (QOL), cosmetic outcome and survival rates

et al. 2020

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Purpose: The latissimus dorsi muscle has long been used in breast cancer (BC) patients for reconstruction. This study aimed to compare early stage BC patients who had partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (MI) with respect to quality of life (QoL), cosmetic outcome (CO), and survival rates. Patients and methods: The data of patients who underwent PM + MLDF (Group 1) and M + I (Group 2) between January 2010 and January 2018 were evaluated. Both groups were compared in terms of demographics, clinical and pathological characteristics, surgical morbidity, survival, quality of life, and cosmetic results. The EORTC-QLQ C30 and EORTC-QLO BR23 questionnaires and the Japanese Breast Cancer Society (JBCS) Cosmetic Evaluation Scale were used to assess the quality of life and the cosmetic outcome, respectively.

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The effect of wound complications following mastectomy with immediate reconstruction on breast cancer recurrence

Cited by 18 publications

References 12 publications

The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis

The effect of postoperative complications on survival and recurrence after surgery for breast cancer: A systematic review and meta-analysis

The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M + I) regarding quality of life (QOL), cosmetic outcome and survival rates

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