The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial

Khazdair, Mohammad Reza; Rajabi, Omid; Balali‐Mood, Mahdi; Beheshti, Farimah; Boskabady, Mohammad Hossein

doi:10.1016/j.etap.2018.01.006

Cited by 30 publications

(26 citation statements)

References 19 publications

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“…It was reported that carvacrol, the main constituent of this plant, decreased the malondialdehyde level but increased activities of superoxide dismutase and catalase in the liver and heart tissues of rats 40,41 . The results of a clinical trial on chemical veterans were also consistent with previous studies and the present study and showed that Z. multiflora leads to a reduction of malondialdehyde but increased thiol content, superoxide dismutase, and catalase activities 7 …”

Section: Discussionsupporting

confidence: 92%

“…The results of clinical trials performed on asthmatic patients and sulfur mustard‐exposed veterans confirmed the findings of the present study. In these trials, pulmonary function test values were significantly increased after treatment with Z. multiflora 7,19,27 …”

Section: Discussionmentioning

confidence: 84%

“…COPD patients were randomly divided to 3 groups by the block randomization method: Group I included 13 patients who received placebo. Group II included 13 patients who received 3 mg/kg/day of Z. multiflora extract (Z3). Group III included 16 patients who received 6 mg/kg/day of Z. multiflora extract (Z6) 7,19 …”

Section: Methodsmentioning

confidence: 99%

“…Z. multiflora has a long history in traditional and pharmaceutical uses and showed anti‐inflammatory, antioxidant, antibacterial, smooth muscle relaxant, antidiarrheal, and antitussive effects 4‐6 . Several pharmacological effects were shown for this plant including the effects on respiratory system conditions such as cough, bronchitis, respiratory disorders of chemical war victims, 7,8 lung inflammation and pathological changes and emphysema in animal models, 9 gastrointestinal disorders like inflammatory bowel disease, and colon inflammation, 10,11 and inflammatory diseases including acute and chronic inflammation 1 . However, mild side effects such as dizziness, nausea, vomiting, stimulation of mucosal membranes, and dermatitis were described for this plant 5 …”

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confidence: 99%

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A Randomized, Doubled‐Blind Clinical Trial on the Effect of Zataria multiflora on Clinical Symptoms, Oxidative Stress, and C‐Reactive Protein in COPD Patients

Ghorani

Rajabi

Mirsadraee

et al. 2020

The Journal of Clinical Pharma

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The effects of Zataria multiflora on clinical symptoms, pulmonary function tests, oxidative stress, and C‐reactive protein levels in chronic obstructive pulmonary disease (COPD) patients were evaluated. Forty‐five patients were allocated to 3 groups: placebo group and 2 groups that received 3 and 6 mg/kg/day Z. multiflora extract (Z3 and Z6) for 2 months. Clinical symptoms, pulmonary function tests, oxidative stress, and serum C‐reactive protein levels were evaluated pretreatment (step 0) and 1 (step I) and 2 (step II) months after treatment. Clinical symptoms including breathlessness and chest wheeze in Z3‐ and Z6‐treated groups and sputum production only in the Z6‐treated group were significantly improved 1 and 2 months after treatment compared with baseline values (P < .01 to P < .001). The FEV1 was significantly increased after 2 months of treatment with Z3 and Z6 (P < .05 to P < .01). Malondialdehyde and nitrite levels were significantly decreased after a 2‐month treatment with Z6 compared with step 0 (P < .05 to P < .01). The thiol contents in the Z6 group as well as superoxide dismutase and catalase activities in both groups treated with the extract were significantly increased in step II compared with step 0 (P < .05 to P < .01). The C‐reactive protein level at the end of the study was significantly reduced compared with the step 0 in both treated groups (P < .05 for both cases). Two‐month treatment with Z. multiflora improved clinical symptoms, pulmonary function tests, oxidative stress, and C‐reactive protein in COPD patients. The results suggest that this herbal medicine could be of therapeutic value as a preventive drug for the treatment of COPD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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A Randomized, Doubled‐Blind Clinical Trial on the Effect of Zataria multiflora on Clinical Symptoms, Oxidative Stress, and C‐Reactive Protein in COPD Patients

Ghorani

Rajabi

Mirsadraee

et al. 2020

The Journal of Clinical Pharma

Self Cite

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“…Interestingly, Z. multiflora (5 and 10 mg·kg·day) was tested in veterans, 27–30 years after exposed to sulfur mustard, to evaluate the effects in lung function. Their findings showed reduction of inflammatory cells and oxidant biomarkers, increasing antioxidant biomarkers, and improvement of pulmonary function tests (Khazdair et al, ). This plant has also shown a possible therapeutic potential against asthma in a recent study in asthmatic patients (Alavinezhad et al, ; Table ).…”

Section: Resultsmentioning

confidence: 99%

Thymol, thyme, and other plant sources: Health and potential uses

Salehi

Mishra

Shukla

et al. 2018

Phytotherapy Research

396

243

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Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry. The interest in the formulation of pharmaceuticals, nutraceuticals, and cosmeceuticals based on thymol is due to several studies that have evaluated the potential therapeutic uses of this compound for the treatment of disorders affecting the respiratory, nervous, and cardiovascular systems. Moreover, this compound also exhibits antimicrobial, antioxidant, anticarcinogenesis, anti-inflammatory, and antispasmodic activities, as well as a potential as a growth enhancer and immunomodulator. In the present review, these bioactivities have been covered because some of them can contribute to explain the ethnopharmacology of thymol and its main source, T. vulgaris. Other important aspects about thymol are discussed: its toxicity and bioavailability, metabolism, and distribution in animals and humans.

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Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

et al. 2021

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Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional medicine, especially for treating inflammatory conditions C. longa and its main constituent, curcumin (CUR), showed various pharmacological effects such as antioxidant and anti-microbial properties. The updated knowledge of anti-inflammatory, antioxidant, and immunomodulatory effects of C. longa and CUR is provided in this review article. Pharmacological effects of C. longa, and CUR, including anti-inflammatory, antioxidant, and immunomodulatory properties, were searched using various databases and appropriate keywords until September 2020. Various studies showed anti-inflammatory effects of C. longa and CUR, including decreased white blood cell, neutrophil, and eosinophil numbers, and its protective effects on serum levels of inflammatory mediators such as phospholipase A2 and total protein in different inflammatory disorders. The antioxidant effects of C. longa and CUR were also reported in several studies. The plant extracts and CUR decreased

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The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial

Cited by 30 publications

References 19 publications

A Randomized, Doubled‐Blind Clinical Trial on the Effect of Zataria multiflora on Clinical Symptoms, Oxidative Stress, and C‐Reactive Protein in COPD Patients

A Randomized, Doubled‐Blind Clinical Trial on the Effect of Zataria multiflora on Clinical Symptoms, Oxidative Stress, and C‐Reactive Protein in COPD Patients

Thymol, thyme, and other plant sources: Health and potential uses

Experimental and clinical reports on anti‐inflammatory, antioxidant, and immunomodulatory effects ofCurcuma longaand curcumin, an updated and comprehensive review

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