The effect of zinc supplementation on the effects of lead on the rat testis

Batra, Navneet; Nehru, Bimla; Bansal, M. P.

doi:10.1016/s0890-6238(98)00030-6

Cited by 83 publications

(60 citation statements)

References 32 publications

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“…As evidence has shown that Zn exists in spermatozoa within the seminiferous tubules and helps spermatogenesis 19,23) , Pb may result in disruption of the metabolic functions of enzymes containing Zn, inducing testicular damage. Batra et al 9) reported that there was a 30% reduction in Pb deposition in the testes when Zn was coadministered. The protective effect of Zn on reproductive toxicity of Pb may be attributed to competition between Pb and Zn, or reduction of available Pb-binding sites in the testicular tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Flora et al 8) demonstrated that Zn administration together with Pb decreased hepatic and renal uptake of Pb and reduced Pb-induced inhibition of blood ALAD activity. In addition, Batra et al 9) reported that testicular degeneration was observed in rats exposed to high doses of Pb and that, with a concomitant administration of Pb and Zn, both testes and epididymides presented nearly normal pictures. However, these experimental studies mainly involved in the protective effects of Zn against Pb toxicity to the hematopoietic and male reproductive systems, and there are few reports on the interactions of Zn in Pb toxicities to other organs.…”

Section: Cerklewski and Forbesmentioning

confidence: 99%

“…The rats were randomly segregated into four groups (7 males and 7 females in each group). In order to induce obvious toxic effects of Pb, a dose of 25 mg/ kg was selected according to literatures [9][10][11] . Pb acetate or Zn acetate was dissolved in sterile double distilled water (DDW).…”

Section: Animals and Treatmentmentioning

confidence: 99%

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Effects of Zinc Coadministration on Lead Toxicities in Rats

et al. 2007

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In order to investigate the effects of Zn on Pb toxicities. Proportion of abnormal sperm, percentage of micronucleated polychromatic erythrocyte (MPCE), serum thyroid hormones (T 3 , T 4 ) and cortisol were measured. Rats received intraperitoneal injection of 25 mg/kg Pb acetate, 4 mg/kg Zn acetate, both Pb acetate and Zn acetate, or normal saline as controls, once every two days, 7 times in total. No significant differences in whole blood Pb were detected between groups received Pb alone or both Pb and Zn. On the contrary, the concentration of whole blood Zn in the group given Zn alone was significantly higher than that in the group that received both Pb and Zn. In the groups given Pb alone or both Pb and Zn, proportion of abnormal sperm, frequency of MPCE and serum cortisol were significantly higher than those in controls, whereas serum T 3 and T 4 were significantly lower than in controls. In the group given both Pb and Zn, T 4 was decreased most obviously among the four groups. While the proportion of abnormal sperm was less in the group given both Pb and Zn than in the group given Pb alone. These findings suggest that Zn coadministration might alleviate toxic effects of Pb on the male reproductive system, whereas it could enhance the toxicity on thyroid function. Zn did not affect the toxicities of Pb on cytogenetic systems as indicated by MPCE percentage, and on serum cortisol levels under the dose of the present study. Our results suggested the double-edged effects of Zn on Pb toxicities in different organs. Therefore, the effects of Zn on Pb toxicities should be evaluated systematically.

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Section: Discussionmentioning

confidence: 99%

Section: Cerklewski and Forbesmentioning

confidence: 99%

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Effects of Zinc Coadministration on Lead Toxicities in Rats

et al. 2007

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“…Some scientists have shown that in Znsupplemented animals, Pb concentration was significantly reduced in kidney, bone, liver, spleen, testis, and blood compared to animals treated only with Pb. The concentration of Pb in these organs was reduced 30 to 50% by Zn coadministration [21]. It may explain why the appeared increase of synthesis of MT was reduced after Zn co-administration.…”

Section: Resultsmentioning

confidence: 91%

The effects of lead and zinc ion exposure on the antioxidant status of mice liver

Šulinskienė¹,

Sadauskienė²,

Ivanov³

2011

Biologija

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The present study was conducted to investigate the effect of lead (Pb) and / or zinc (Zn) ions on the content of metallothionein (MT), reduced glutathione (GSH) and malondialdehyde (MDA) in mouse liver.Two weeks of mice intraperitoneal treatment with ZnSO 4 and Pb(CH 3 COO) 2 solutions, increased the content of MT by 25% and 55%, respectively. Mice pre-treatment with ZnSO 4 for 20 min before Pb(CH 3 COO) 2 injections, attenuated the effect of Pb 2+ and partly reduced (by 30%) the increase of MT content in mice liver. Two weeks of administration with Pb(CH 3 COO) 2 solution, induced the decrease of GSH content by 22% comparing to the control. Treatment with ZnSO 4 didn't have any effect on the content of GSH. Pre-treatment with ZnSO 4 for 20 min before Pb(CH 3 COO) 2 injections decreased GSH content in mice liver by 48% as compared to the control group of mice. Neither Pb 2+ nor Zn 2-caused any remarkable alterations on MDA content in liver of mice.

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“…19 Conversely, zinc administration will counteract the oxidative stress created in the testes by exposure to lead. [20][21] as well as the peroxidative damage induced by ischemia-reperfusion as a consequence testicular torsion-detorsion. 22 Zinc administration has also been shown to attenuate the testicular oxidative DNA damage induced by Figure 1.…”

Section: Small Molecular Mass Antioxidantsmentioning

confidence: 99%