The effect on lymphocyte chromosomes of additional radiation burden due to fallout in Salzburg (Austria) from the Chernobyl accident

Pohl-Rüling, J.; Haas, Oskar A.; Brøgger, Anton; Obe, G.; Lettner, Herbert; Daschil, F.; Atzmüller, C; Lloyd, David; Kubiak, R.; Natarajan, A.T.

doi:10.1016/0165-7992(91)90024-x

Cited by 43 publications

(7 citation statements)

References 9 publications

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“…In our study, where samples were taken at long intervals after the exposure or in the case of chronic exposure to low doses of ionising radiation, the accumulation of unstable chromosome aberrations together with their decline make it absolutely impossible to reconstruct the dose. Nevertheless, since dicentric chromosomes may essentially be considered hallmarks of exposure to ionising radiation [11,12], many authors have also used the conventional cytogenetic approach to evaluate the consequences of chronic low-dose contamination [14,15,16,17,18,19,20]. We chose to adopt this approach for our study as it represents an important instrument for an overall evaluation of current risk due to accidental exposure to ionising radiation.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site

Testa¹,

Stronati²,

Ranaldi³

et al. 2001

Radiation and Environmental Biophysics

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The Semipalatinsk region (Kazakhstan Republic) has been affected by extensive radioactive contamination due to more than 450 nuclear tests of which almost 100 were exploded in the atmosphere. The present results refer to cytogenetic assessments in a study cohort of the population of Dolon, a settlement located on the NE boundary of the nuclear weapon test site, which was exposed to elevated doses of ionising radiation primarily due to the first Soviet nuclear test in 1949. Conventional cytogenetic analyses were carried out on 21 blood samples from individuals (more than 50 years old) living in Dolon since the very beginning of nuclear testing. A matched control group included 20 individuals living in non-contaminated areas. Higher frequencies of chromosome aberrations were found in the Dolon cohort compared to the control group, even though they remain within the range of the background levels reported for large normal human population studies on elderly individuals.

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Section: Discussionmentioning

confidence: 99%

Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site

Testa¹,

Stronati²,

Ranaldi³

et al. 2001

Radiation and Environmental Biophysics

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“…Geographic studies in western Europe have also produced contradictory results (55)(56)(57). No clear link appears to associate the excess of chromosomal anomalies with the doses received by inhabitants, estimated geographically on the basis of fallout measurements.…”

Section: Case Clusters In Europe and Asia Minormentioning

confidence: 97%

Chernobyl, 10 Years After: Health Consequences

Bard¹,

Verger²,

Hubert³

1997

Epidemiologic Reviews

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“…Elevated rates of chromosome aberrations have been observed in situations such as the occupational exposure of nuclear dockyard workers to mixed neutron-Á-radiation [9] and medical workers to diagnostic X-rays [4,12]. The same is true for those who were exposed to radioactive cesium from the Chernobyl reactor accident [5,13,16,17,21]. In a preliminary study, we reported that there was no significant difference in the incidence of chromosome aberrations between people Wang-Wuu/Tai/Wuu/Lin/Chen/Wuu residing in and not residing in radioactively contaminated houses [7].…”

Section: Introductionmentioning

confidence: 58%

Chromosome Aberrations in Lymphocytes of Residents Living in Buildings Constructed with Radioactively Contaminated Rebars

Wang-Wuu¹,

Tai

Wuu

et al. 2001

Journal of Biomedical Science

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Using the G-banding technique, we examined lymphocytes from 90 individuals (43 males and 47 females, median age 31 years) living in buildings constructed with radioactively contaminated rebars. Forty-five nonexposed control subjects (22 males and 23 females, median age 30 years), matched to the radiation-exposed individuals by sex and age, were selected for comparison. At least 500 metaphases were checked for each individual. All recognizable structural aberrations of chromosomes or chromatids were recorded. After adjusting for age and smoking status, both the percentage of cells with aberrant chromosomes (PCAC) and the number of aberrant chromosomes per 100 cells (NAC) were found to be significantly higher in the radiation-exposed females than in the control females (p < 0.05 for PCAC and NAC). This difference, however, was not observed in the comparison of radiation-exposed and control males. This suggests a possible interaction between sex and radiation exposure in their effects on chromosome aberrations.

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The effect on lymphocyte chromosomes of additional radiation burden due to fallout in Salzburg (Austria) from the Chernobyl accident

Cited by 43 publications

References 9 publications

Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site

Cytogenetic biomonitoring carried out in a village (Dolon) adjacent to the Semipalatinsk nuclear weapon test site

Chernobyl, 10 Years After: Health Consequences

Chromosome Aberrations in Lymphocytes of Residents Living in Buildings Constructed with Radioactively Contaminated Rebars

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