The effective components of Huanglian Jiedu Decoction against sepsis evaluated by a lipid A-based affinity biosensor

Chen, Guirong; Zhang, Gang; Li, Mingyu; Jing, Jing; Wang, Jing; Zhang, Xu; Mackie, Brianna; Dou, Deqiang

doi:10.1016/j.jep.2016.03.064

Cited by 17 publications

(13 citation statements)

References 25 publications

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“…Traditional Chinese medicine researchers found that Baicalin has anti‐virus, improve myocardial ischemia and anti‐arrhythmia properties (Chu, Chu, & Teng, ; Qiu et al, ). Besides that, Baicalin and geniposide was reported to neutralize LPS‐triggered effects by binding with lipid A and then declining production of TNF‐α and IL‐6 (Chen et al, ). Similarly, in our study, we found that LPS stimulation triggered obvious cell apoptosis and production of cytokines.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Baicalin relieves lipopolysaccharide‐evoked inflammatory injury through regulation of miR‐21 in H9c2 cells

Liu

Wang

Zhao

2020

Phytotherapy Research

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Myocarditis is a common heart disease which lacks effective treatment till now.Baicalin possesses plenty of activities, including anti-inflammation. In this investigation, we attempted to investigate the influences of Baicalin on Lipopolysaccharide (LPS)-evoked H9c2 cells.Cells viability, apoptosis, and expressions of apoptosisassociated proteins were, respectively, measured utilizing CCK-8 assay, flow cytometry and western blot. The levels of IL-6 and TNF-α were detected through enzyme-linked immunosorbent assay, western blot and qRT-PCR. miR-21 expression was detected through qRT-PCR and was silenced using cell transfection. The expressions of NF-κB and PDCD4/JNK pathways related proteins were measured through western blot. We found that LPS stimulation induced cell apoptosis and upregulation of IL-6 and TNF-α. Baicalin treatment effectively suppressed LPS-induced inflammation and apoptosis. The NF-κB and PDCD4/JNK pathways were blocked by Baicalin. Additionally, the enhanced expression of miR-21 triggered by LPS was further elevated by Baicalin. Further study revealed that the inhibiting effects of Baicalin on LPS-evoked injury were largely attenuated by knockdown of miR-21. Moreover, the associated NF-κB and JNK pathways, which were suppressed by Baicalin treatment, were then activated by knockdown of miR-21. Our present study revealed that Baicalin alleviated LPS-evoked inflammatory injury via suppressing the NF-κB and PDCD4/JNK pathways through regulating miR-21 expression. K E Y W O R D S apoptosis, Baicalin, inflammatory injury, MiR-21, myocarditis

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Section: Discussionmentioning

confidence: 99%

Retracted: Baicalin relieves lipopolysaccharide‐evoked inflammatory injury through regulation of miR‐21 in H9c2 cells

Liu

Wang

Zhao

2020

Phytotherapy Research

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“…Geniposide exhibited high binding affinity for lipid A, the bioactive center of lipopolysaccharide (LPS). In LPS-induced sepsis model mice, geniposide lowered LPS levels and release of IL-6 and TNF- α induced by LPS and exhibited protective activities on liver, heart, and lung [79].…”

Section: Pharmacology Actionsmentioning

confidence: 99%

Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

Zhou

Zhang

Rahman

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Geniposide is a well-known iridoid glycoside compound and is an essential component of a wide variety of traditional phytomedicines, for example, Gardenia jasminoides Elli (Zhizi in Chinese), Eucommia ulmoides Oliv. (Duzhong in Chinese), Rehmannia glutinosa Libosch. (Dihuang in Chinese), and Achyranthes bidentata Bl. (Niuxi in Chinese). It is also the main bioactive component of Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides Ellis. Increasing pharmacological evidence supports multiple medicinal properties of geniposide including neuroprotective, antidiabetic, hepatoprotective, anti-inflammatory, analgesic, antidepressant-like, cardioprotective, antioxidant, immune-regulatory, antithrombotic, and antitumoral effects. It has been proposed that geniposide may be a drug or lead compound for the prophylaxis and treatment of several diseases, such as Alzheimer’s disease, Parkinson’s disease, diabetes and diabetic complications, ischemia and reperfusion injury, and hepatic disorders. The aim of the present review is to give a comprehensive summary and analysis of the pharmacological properties of geniposide, supporting its use as a medicinal agent.

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“…Based on its powerful anti-inflammatory ability, a large number of studies have proved that HLJDD is an effective prescription for treating various inflammatory diseases, such as inflammatory bowel disease [109], gastritis [110,111], and sepsis [4,22,[112][113][114]. Sepsis is a clinical syndrome characterized by systemic inflammation.…”

Section: Anti-inflammatory and Anti-allergymentioning

confidence: 99%

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Zhang

Zhu

2019

Chin Med

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Huang-Lian Jie-Du decoction (HLJDD), a famous traditional Chinese prescription constituted by Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Fructus Gradeniae, has notable characteristics of dissipating heat and detoxification, interfering with tumors, hepatic diseases, metabolic disorders, inflammatory or allergic processes, cerebral diseases and microbial infections. Based on the wide clinical applications, accumulating investigations about HLJDD focused on several aspects: (1) chemical analysis to explore the underlying substrates responsible for the therapeutic effects; (2) further determination of pharmacological actions and the possible mechanisms of the whole prescription and of those representative ingredients to provide scientific evidence for traditional clinical applications and to demonstrate the intriguing molecular targets for specific pathological processes; (3) pharmacokinetic feature studies of single or all components of HLJDD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological and pharmacokinetic profiles of HLJDD and its herbal or pharmacologically active chemicals, as well as our understanding which further reveals the significance of HLJDD clinically.

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The effective components of Huanglian Jiedu Decoction against sepsis evaluated by a lipid A-based affinity biosensor

Cited by 17 publications

References 25 publications

Retracted: Baicalin relieves lipopolysaccharide‐evoked inflammatory injury through regulation of miR‐21 in H9c2 cells

Retracted: Baicalin relieves lipopolysaccharide‐evoked inflammatory injury through regulation of miR‐21 in H9c2 cells

Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

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