The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis

Haigh, Laura; Kirk, Colette; Gendy, Khalil El; Gallacher, Jennifer; Errington, Linda; Mathers, John C.; Anstee, Quentin M.

doi:10.1016/j.clnu.2022.06.037

Cited by 92 publications

(69 citation statements)

References 56 publications

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“…Various nutritional interventions targeting a weight loss ≥ 5% has shown to be effective in the management of MAFLD[ 14 , 23 , 24 ]. Aim of all forms of nutritional interventions for MAFLD is to reduce the proportion of macronutrient content of the diet to achieve total energy deficit by restricting intake of simple carbohydrates, saturated fat, and added sugars, along with adoption of healthier eating options like a Mediterranean diet.…”

Section: Management Approach To Mafldmentioning

confidence: 99%

Management of metabolic-associated fatty liver disease: The diabetology perspective

Jeeyavudeen¹,

Khan²,

Fouda³

et al. 2023

World J Gastroenterol

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The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists. Management of these individual disorders in a patient should be addressed wholistically using an appropriate multidisciplinary team approach involving both the specialists and, when necessary, liaising with dieticians and surgeons. This comprehensive review is to compile the current evidence from a diabetologist's perspective on MAFLD and T2DM and to suggest optimal management strategies.

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Section: Management Approach To Mafldmentioning

confidence: 99%

Management of metabolic-associated fatty liver disease: The diabetology perspective

Jeeyavudeen¹,

Khan²,

Fouda³

et al. 2023

World J Gastroenterol

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“…An important study by Kirk et al (2009) 32 reported similar changes in body weight, body composition, and IHLC after 7% of weight loss (i.e., after around 11 weeks) following a hypocaloric low-carbohydrate diet (LCD) vs. a high-carbohydrate diet (HCD) despite short-term effects in favor of LCD 32 (i.e., after 48h). Again, studies associating the degree of weight loss with the extent of histological improvement 11 and improvement of metabolic parameters 33 strongly favor a dose-dependent effect of nutritional/lifestyle interventions beyond macronutrient composition 34 . Interestingly, a recent meta-analysis of observational studies including >100,000 individuals has shown that the only difference between NAFLD and controls was a higher calorie intake while the macronutrient composition did not significantly differ 35 .…”

Section: Calorie Restriction and Hypocaloric Dietmentioning

confidence: 99%

Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

Semmler¹,

Datz²,

Trauner³

2023

Clin Mol Hepatol

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Shire, speaker fees from Bristol-Myers Squibb, Falk, Gilead, Intercept and MSD, as well as travel support from AbbVie, Falk, Gilead, and Intercept. He is also co-inventor of patents on the medical use of 24-norursodeoxycholic acid. List of abbreviations: BMIbody mass index; CAPcontrolled attenuation parameter; DNLde-novo lipogenesis; HCDhigh-carbohydrate diet; IFintermittent fasting; IHLCintrahepatic lipid content; LCDlow-carbohydrate diet; LSMliver stiffness measurement; MD -Mediterranean diet; MUFAmono-unsaturated fatty acids; NAFLDnon-alcoholic fatty liver disease; NASHnon-alcoholic steatohepatitis; PUFApoly-unsaturated fatty acids; RCTrandomized controlled trial; SFAsaturated fatty acids; SSB -Sugar-sweetened beverages; TRFtime-restricted feeding;

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“…In a recent meta-analysis [ 41 ], investigators showed that the available data to date suggest that there is an inverse relationship between Mediterranean diet intake and liver steatosis [0.95 (CI: 0.9–1); p = 0.05], probably with the implication of improvements in some factors such as body mass index, (Effect size = −1.23 kg/m 2 (CI: −2.38 to −0.09), triglycerides (Effect size = −33.01 mg/dL (CI: −52.84 to −13.18), or insulin resistance/insulin sensitivity (Effect size = −0.94; CI: −1.29 to −0.58). In a second meta-analysis, Haigh et al [ 42 ] reviewed data from randomized and clinically controlled trials describing the effects of the Mediterranean diet and calorie restriction on NAFLD biomarkers. The meta-analysis showed that dietary interventions reduce alanine aminotransferase ( p < 0.001), aspartate aminotransferase ( p = 0.004), fatty liver index ( p < 0.001), and liver steatosis ( p = 0.02).…”

Section: Nutritional Treatment In Nafldmentioning

confidence: 99%

Different Dietary Approaches, Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A Literature Review

et al. 2023

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Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease and is also associated with other harmful entities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a significant public health concern worldwide, impacting individuals of all ages, and its prevalence is projected to increase in the near future due to its connection with obesity. Intrinsic (genetics) and external (lifestyle) factors may also modulate NAFLD, and, in turn, may partly explain the observed relationship between NAFLD and cardiovascular disease (CVD). Although many drugs are been tested to treat NAFLD, to date, no drug has indication to specifically treat this disorder. Thus, the current management of NAFLD relies on lifestyle modifications and specifically on weight loss, physical activity, and the intake of a healthy diet. In the present narrative review, we will discuss the effects of certain dietary patterns on NAFLD incidence and progression.

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The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis

Cited by 92 publications

References 56 publications

Management of metabolic-associated fatty liver disease: The diabetology perspective

Management of metabolic-associated fatty liver disease: The diabetology perspective

Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease

Different Dietary Approaches, Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A Literature Review

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