The effectiveness, in vitro, of miconazole and keteconazole combined with tissue conditioners in inhibiting the growth of Candida albicans

Abstract

Two recent antifungal agents, miconazole and ketoconazole, were combined with three tissue conditioners and tested in vitro for their effects on the growth of Candida albicans. Studies for comparison were carried out using the earlier antifungal agents, amphotericin B and nystatin. Miconazole and ketoconazole were as effective as nystatin in completely inhibiting the growth of Candida albicans. The ineffectiveness of amphotericin B when combined with tissue conditioners as an antifungal agent was confirmed. (See Addendum p.181.).

Invitro Antifungal Evaluation of Denture Soft Liner Incorporated with Tea Tree Oil: A New Therapeutic Approach Towards Denture Stomatitis

“…punica granatum [13], Nystatin [6,14], Itra conazole [6], Miconazole [15], Ketoconazole [15], Clotrimazole [1] in the resilient liners with varying degree of success.…”

Comparison of the Effect of Nystatin and Titanium Dioxide Addition on Candida Colonization in Soft Lining Material

“…6 Several in vitro and in vivo studies demonstrated that the integration of fungicidal factors into tissue conditioners are useful and practical for the inhibition or prevention of plaque formation and improved recovery in denture stomatitis. 6,21,[25][26][27][28][29] Gruber et al 30 reported that silicone tissue conditioners and soft liners impregnated with zinc undecylenate eliminated colonization by Candida. In microbiological assays, nystatin restricted the emergence of C. albicans when it was used with a tissue conditioner.…”

“…28 In a study of the antimycotic action of nystatin-impregnated soft denture lining materials and the influence of 8 an aqueous environment on the fungicidal characteristics, Truhlar et al 6 showed that doses of 1,000,000 U and 500,000 U were useful in maintaining the drug-leaching quantity above the minimum inhibitory concentration for antifungal action. Radnai et al 12 demonstrated that miconazole gel, combined with a Viscogel tissue conditioner, restricted the emergence of C.…”

Efeito da incorporação de agentes antimicrobianos sobre propriedades físicas de materiais resilientes temporários para base de prótese

“…A incorporação de agentes antimicrobianos nos materiais resilientes temporários para base de prótese tem sido sugerida para prolongar sua longevidade clínica, prevenir o acúmulo de biofilme protético (DOUGLAS; WALKER, 1973;NIKAWA et al, 1997;SCHNEID, 1992), inibir a colonização por C. albicans (AMIN et al, 2009;CARTER;KERR;SHEPHERD, 1986;CHOPDE et al, 2012;FALAH-TAFTI et al, 2010;GEERTS;STUHLINGER;BASSON, 2008;QUINN, 1985;RADNAI, MARTA et al, 2010) e auxiliar no tratamento da estomatite protética (GEERTS; STUHLINGER; BASSON, 2008;LAMB;MARTIN, 1983;SKUPIEN et al, 2013). Esse protocolo foi preconizado para permitir a liberação gradual dos fármacos na cavidade bucal, tratando de maneira simultânea os tecidos paraprotéticos injuriados e a infecção por Candida ao longo da vida útil desses materiais temporários, (MATSUURA et al, 1997) que corresponde a um período semelhante ao de um tratamento com antifúngico tópico convencional, ou seja, 14 dias (SCHNEID, 1992; TRUHLAR, MARY R; SHAY, KENNETH; SOHNLE, PETER, 1994).…”