The Effectiveness of Benzydamine Hydrochloride Spraying on the Endotracheal Tube Cuff or Oral Mucosa for Postoperative Sore Throat

Abstract

This study indicates that spraying BH on the ET cuff decreases the incidence and severity of POST without increased BH-related adverse effects.

Effect of prophylactic benzydamine hydrochloride on postoperative sore throat and hoarseness after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled trial

“…Furthermore, a previous study found that 8-10% of patients experienced local stinging or numbness of the throat and mouth when BH was topically applied to the oral mucosa before anesthesia induction. 12 Conversely, Mazzarella et al 23 found that applying BH to the oropharyngeal cavity immediately before intubation and reapplying regularly for 48 hr after surgery produced a therapeutic effect without local or systemic side effects. Moreover, Huang et al 12 reported that patients did not experience BH-related adverse effects when the drug was applied to the tracheal tube cuff.…”

“…19,20 Group BH = benzydamine hydrochloride treatment group; Group S = saline treatment group; PCA = patient-controlled analgesia; VATS = videoassisted thoracic surgery Previous studies have shown that BH administered as either a prophylactic oral gargle or a spray on tracheal tube cuffs reduces the incidence and severity of postoperative sore throat. 11,12,21 Moreover, pre-emptive BH application to the pharynx has been found to decrease the incidence of sore throat following the use of a laryngeal mask 22 A postoperative flexible laryngoscopic assessment of vocal cord injuries revealed that the main injuries caused by DLT intubation are redness and edema at the vocal folds. 5 Thus, the anti-inflammatory and analgesic effect of BH can alleviate the sore throat and hoarseness caused by DLT intubation, particularly when it is applied to the DLT cuff and oropharyngeal cavity.…”

“…3 Benzydamine hydrochloride (BH), a topical nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, has been reported to reduce the incidence and severity of postoperative sore throat when administered as an oral gargle or spray on the ETT cuff or oropharyngeal cavity. 11,12 As such, we evaluated whether applying BH to the ETT cuff and oropharyngeal cavity would reduce postoperative sore throat and hoarseness in patients with DLT tracheal intubation.…”

Dose-dependent effectiveness of ketamine nebulisation in preventing post-operative sore throat due to tracheal intubation.

“…The incidence of post-operative sore throat varies from 21 to 66%. 1 Localised trauma to the mucosa during laryngoscopy and intubation leads to aseptic inflammation of the pharyngeal mucosa leading to post-operative sore throat. 2 Many non-pharmacological and pharmacological methods have been tried to reduce the incidence and severity of post-operative sore throat.…”

The effects of lidocaine spray and intracuff alkalinized lidocaine on the occurrence of cough at extubation: a double-blind randomized controlled trial

“…[6][7][8][9][10] Different methods have been proposed to decrease the adverse effects associated with mucosal irritation caused by the endotracheal tube (ETT), including the administration of opioids, extubation under deep anesthesia, use of fluticasone, and injection of intravenous lidocaine. 4,[10][11][12][13][14][15] Although intravenous anesthetics have been shown to be effective in reducing the incidence of cough at emergence, time can be delayed until the patient can respond to simple orders. 16 Thus, topical local anesthetics represent an attractive alternative to suppress cough while maintaining rapid awakening.…”