The Effectiveness of bFGF in the Treatment of Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis

Huang, Juntao; Teh, Bing Mei; Eikelboom, Robert H.; Han, Liyuan; Xu, Guodong; Yao, Xu; Hu, Yi; Zheng, Minghao; Shen, Yi

doi:10.1097/mao.0000000000002628

Cited by 27 publications

(37 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TM perforation, if left untreated, can cause relapsing infections in the middle ear, hearing loss and otogenic complications [ 5 , 23 ]. Tympanoplasty is considered a relatively useful otolaryngological surgical procedure to close ruptures [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…An earlobe fat graft can achieve anatomic and functional success for small perforations, but the results are less satisfactory for large perforations [ 26 – 28 ]. Over the past decades, alternatives to resolve the limitations of conventional tympanoplasty have been widely explored [ 29 ], including the use of scaffold materials [ 6 ], bioactive molecules [ 5 , 30 ] and cells [ 31 , 32 ]. These new technologies should ideally yield more advantages than conventional tympanoplasty.…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy in between hearing results and healing results may be due to the small number of enrolled patients. In addition to adding more studies with larger populations to obtain more reliable results, other factors also influenced the hearing results [ 5 ]. For patients with TM perforations, the outcome of hearing function for TM repair depends on factors such as graft type, surgical approach, Eustachian tube function, and the site and size of perforations [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…For patients who undergo PRP therapy, the healing time of TM regeneration [ 49 ] and hospitalization duration [ 16 ] were shortened. These results are quite clinically relevant, since earlier closure reduces medical costs associated with treatment and follow-up; in addition, the need for fewer precautions to prevent water from entering the ear canal allows patients to return to social activities more quickly [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tympanoplasty with autografts (e.g., temporalis fascia) is the gold standard surgical treatment for TM perforation and achieves high success rates according to a previous study [ 3 ]. However, an ideal repair material has yet to be identified because of various limitations [ 4 , 5 ]. Patients may suffer from reperforation, middle ear infections or other complications after surgeries.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

Huang

Shi

et al. 2021

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Background Tympanic membrane (TM) perforation is quite common in the clinical setting. Chronic TM perforations require surgical treatments such as myringoplasty. Currently, platelet-rich plasma (PRP) is a novel, effective substance that is increasingly utilized for TM perforation repair. This study aims to evaluate the effectiveness of PRP in the application of TM perforation repair. Methods A systematic search was conducted to screen the Medline, Embase, Cochrane, Scopus and Web of Science databases up to July 2020. Studies were identified in accordance with the selection criteria by two coauthors independently. Data regarding the healing and hearing outcomes were pooled and analyzed via Review Manager version 5.3 and STATA version 12.0 software. Odds ratio (OR) was utilized to compare the closure rate. Furthermore, the results of hearing improvements and incidence of complications were also compared to evaluate the effectiveness of PRP. Results A total of eight studies with 455 participants were eligible according to the selection criteria. Compared to conventional surgery, the OR of closure was 2.70 (95% CI: 1.27 to 5.76, P = 0.01, I2 = 0%) in randomized controlled trial (RCT) subgroup and 6.18 (95% CI: 2.22 to 17.25, P = 0.0005, I2 = 0) in non-RCT subgroup. The overall OR of closure was 3.69 (95% CI: 2.02 to 6.74, P<0.0001, I2 = 0%), suggesting a significant effect on the healing of TM perforation. Between preoperative and postoperative hearing results, there is no statistical difference between the PRP and the control groups. Additionally, the use of PRP resulted in a lower incidence of complication than the use of conventional approaches. Conclusion The application of PRP during the TM surgeries can enhance the closure rate, provide similar hearing improvements and decrease the incidence of postoperative complications. Given these advantages, PRP can be considered an effective treatment for TM regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

Huang

Shi

et al. 2021

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

Huang

Teh

et al. 2021

Clinical Laboratory Analysis

Self Cite

View full text Add to dashboard Cite

Objective This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacology‐based identification. Methods The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGkb, TTD, and DrugBank databases. A Venn diagram was generated to show the common targets of HFO and TM, and GO and KEGG analyses were performed to explore the potential biological processes and signaling pathways. The PPI network and core gene subnetwork were constructed using the STRING database and Cytoscape software. A molecular docking analysis was also conducted to simulate the combination of compounds and gene proteins. Results A total of 33 compounds and their related targets were obtained from the TCMSP database. After screening the 393 TM‐related targets, 21 compounds and 22 gene proteins were selected to establish the network diagram. GO and KEGG enrichment analyses revealed that HFO may promote TM healing by influencing cellular oxidative stress and related signaling pathways. A critical subnetwork was obtained by analyzing the PPI network with nine core genes: CASP3, MMP2, IL1B, TP53, EGFR, CXCL8, ESR1, PTGS2, and IL6. In addition, a molecular docking analysis revealed that quercetin strongly binds the core proteins. Conclusion According to the analysis, HFO can be utilized to repair perforations by influencing cellular oxidative stress. Quercetin is one of the active compounds that potentially plays an important role in TM regeneration by influencing 17 gene proteins.

show abstract

A Proof‐of‐Concept Computer Vision Approach for Measurement of Tympanic Membrane Perforations

Nwosu,

Suresh,

Knoll

et al. 2024

The Laryngoscope

View full text Add to dashboard Cite

ObjectiveSize, an important characteristic of a tympanic membrane perforation (TMP), is commonly assessed with gross estimation via visual inspection, a practice which is prone to inaccuracy. Herein, we demonstrate feasibility of a proof‐of‐concept computer vision model for estimating TMP size in a small set of perforations.MethodsAn open‐source deep learning architecture was used to train a model to segment and calculate the area of a perforation and the visualized tympanic membrane (TM) in a set of endoscopic images of mostly anterior and relatively small TMPs. The model then computed relative TMP size by calculating the ratio of perforation area to TM area. Model performance on the test dataset was compared to ground‐truth manual annotations. In a validation survey, otolaryngologists were tasked with estimating the size of TMPs from the test dataset. The primary outcome was the average absolute error of model size predictions and clinician estimates compared to sizes determined by ground‐truth manual annotations.ResultsThe model's average absolute error for size predictions was a 0.8% overestimation for all test perforations. Conversely, among the 38 survey respondents, the average clinician error was a 11.0% overestimation (95% CI, 5.2–16.7%, p = 0.003).ConclusionsIn a small sample of TMPs, we demonstrated a computer vision approach for estimating TMP size is feasible. Further validation studies must be done with significantly larger and more heterogenous datasets.Level of EvidenceN/A Laryngoscope, 2024

show abstract

The Effectiveness of bFGF in the Treatment of Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis

Cited by 27 publications

References 44 publications

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

Comparative efficacy of platelet-rich plasma applied in myringoplasty: A systematic review and meta-analysis

The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

A Proof‐of‐Concept Computer Vision Approach for Measurement of Tympanic Membrane Perforations

Contact Info

Product

Resources

About