The effectiveness of blood amount used in pleurodesis to prevent prolonged air leakage

Akar, Erkan; Haberal, Miktat Arif; Dikiş, Özlem Şengören

doi:10.5606/tgkdc.dergisi.2020.18659

Cited by 6 publications

(15 citation statements)

References 16 publications

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“…Droghetti et al 16 used larger volumes (100–150 ml) of autologous blood and observed that the pneumothorax was resolved earlier compared with reported cases that used smaller volumes of autologous blood. Akar et al 29 compared patients who were injected with either 60 ml or 120 ml of autologous blood, respectively, and the results confirmed that patients who received 120 ml of autologous blood had significantly shorter pneumothorax leakage and extubation times compared with the times reported for patients in the 60 ml group. 29 In the Guo et al 30 study, the patients were divided into four groups that received 0.5 ml/kg, 1 ml/kg, or 2 ml/kg of autologous blood or sterile normal saline, respectively.…”

Section: Discussion and Literature Reviewmentioning

confidence: 88%

“…Akar et al 29 compared patients who were injected with either 60 ml or 120 ml of autologous blood, respectively, and the results confirmed that patients who received 120 ml of autologous blood had significantly shorter pneumothorax leakage and extubation times compared with the times reported for patients in the 60 ml group. 29 In the Guo et al 30 study, the patients were divided into four groups that received 0.5 ml/kg, 1 ml/kg, or 2 ml/kg of autologous blood or sterile normal saline, respectively. The results showed that the success rates associated with the larger volumes (1 ml/kg and 2 ml/kg) were significantly higher than the 0.5 ml/kg group.…”

Section: Discussion and Literature Reviewmentioning

confidence: 88%

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Assessment and review of treatment for secondary spontaneous pneumothorax using medical thoracoscopy-assisted argon plasma coagulation in association with autologous blood pleurodesis

Zhang

Xie

et al. 2021

Ther Adv Respir Dis

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Aims: To evaluate the efficacy of medical thoracoscopy-assisted argon plasma coagulation in association with autologous blood pleurodesis in spontaneous pneumothorax. Patients and methods: Three male patients with spontaneous pneumothorax were treated; medical thoracoscopy-assisted argon plasma coagulation combined with autologous blood pleurodesis was conducted for all patients whose duration of the air leak exceeded 7 days. We systematically reviewed all of the relevant literature to analyze and sum up the treatments of secondary spontaneous pneumothorax. Results: The air leaks were all sealed and no recurrence of pneumothorax was reported. No complications of fever, bleeding, or signs of infection were observed during the process. Conclusion: The authors believe that the combination of medical thoracoscopy-assisted argon plasma coagulation and autologous blood pleurodesis is safe and effective. However, due to the number of patients included in this uncontrolled case study, more cases will be collected in the future. The reviews of this paper are available via the supplemental material section.

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Section: Discussion and Literature Reviewmentioning

confidence: 88%

Section: Discussion and Literature Reviewmentioning

confidence: 88%

Assessment and review of treatment for secondary spontaneous pneumothorax using medical thoracoscopy-assisted argon plasma coagulation in association with autologous blood pleurodesis

Zhang

Xie

et al. 2021

Ther Adv Respir Dis

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“…The advantages of this method are that it does not create chest pain during the application, is effective, and is nonimmunogenic 12 . However, by forming a clot in the chest tube during the procedure, it may prevent air drainage and lead to pressure pneumothorax 13,14 …”

Section: Discussionmentioning

confidence: 99%

“…12 However, by forming a clot in the chest tube during the procedure, it may prevent air drainage and lead to pressure pneumothorax. 13,14 The primary indication for the use of the PGA patch is to strengthen the suture line in operations involving the lung, bronchus, liver, and digestive system, and prevent air leaks. The PGA patch is surgically easy to apply and has different sizes and thicknesses.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the polyglycolic acid patch in preventing prolonged air leakage after pulmonary decortication

Haberal

Akar

Dikiş

et al. 2022

ANZ Journal of Surgery

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Aim This study aimed to investigate the effectiveness of an absorbable polyglycolic acid patch (PGA) in the early prevention of alveolar air leaks after pulmonary decortication operations. Methods Between January 2016 and December 2019, files of 185 patients with pleural effusion, empyema, or hemothorax were examined retrospectively. Thirty‐five patients who underwent decortication surgery were included in the study. Two‐way posteroanterior (PA) chest x‐ray, computed tomography (CT), pulmonary function tests (PFT), arterial blood gas, hemogram, and biochemical tests were performed for all patients before the operation. The patients were divided into two groups. Group 1 was composed of 16 patients (45.7%) with standard decortication, and Group 2 was formed with 19 patients (54.3%) with standard decortication + PGA patch. Results The median age was 55 years (minimum = 25, maximum = 75) and the vast majority (82.9%; n = 29) of patients were males. There was no significant difference between groups in age, aetiology, or sex. The most common etiological cause in both Group 1 and Group 2 was nonspecific infection (56.3% and 73.7%, respectively). When Group 2 and Group 1 were compared regarding median times (day) of air leak cessation (Group 2 = 4; Group 1 = 8.5), chest drain removal (Group 2 = 5; Group 1 = 10), and hospital discharge times (Group 2 = 8; Group 1 = 13),the durations were statistically significantly shorter in Group 2 than in Group 1 (P < 0.001). Conclusion Use of the PGA patch in pulmonary decortication operations significantly reduced the duration of air leaks, drain removal, and discharge time from the hospital in the postoperative period.

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“…The baseline characteristics of the included studies are summarized in Table 1. There were 18 studies included: six were retrospective [5][6][7][8][9][10], seven were randomized controlled trials (RCTs) [11][12][13][14][15][16][17], one study was a non-randomized controlled trial [18], three were prospective studies [19][20][21], and one was a case series involving 11 patients with original data [22]. The sample sizes of the included studies ranged from 11 to 167 [22,20].…”

Section: Study Characteristics and Quality Of The Included Studiesmentioning

confidence: 99%

The Efficacy and Safety of Autologous Blood Patch for Persistent Air Leaks: A Systematic Review and Meta-Analysis

Umar¹,

Nassar²,

Ashfaq³

et al. 2023

Cureus

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Persistent air leaks (PALs) are associated with prolonged hospital stays, contamination and sustained infection of the pleural space, and significant morbidity. A fistulous tract between the alveoli and the pleural space is referred to as an alveolar-pleural fistula (APF), whereas a fistulous tract between the bronchiole and the pleural space is referred to as a bronchopleural fistula (BPF). There is no consensus on the treatment, and multiple modalities exist for the management of persistent air leak (PAL). Autologous blood patch (ABP) is a relatively safe and inexpensive method that has been used for many years for the treatment of PALs.We conducted an electronic database search between 08/24/2022 and 08/27/2022 in PubMed, Embase, and Cochrane using keywords. The following keywords were used: "Blood patch" OR "Autologous blood patch" AND "pleurodesis." Our study included all original studies with the prime focus on the etiology of PALs, clinical characteristics, procedural details of ABP, and outcomes of the proposed treatment. The primary outcomes that were the focus of our study were the time to seal the air leak, the time to remove the chest tube after air leak cessation, and the time to discharge from the hospital. To determine the safety of ABP, we also evaluated the procedural outcomes.Our findings suggest a statistically significant decrease in the time to air leak cessation when compared to the control group (mean difference of -3.75 {95% CI: -5.65 to -1.85; P=0.001}) with considerable heterogeneity of I 2 =85% and P=0.001. However, the difference was not statistically significant when a lower dose of ABP (50 mL) was compared to a higher dose (100 mL) (mean difference of 1.48 {95% CI: -0.07 to 3.02; P=0.06}) and considerable heterogeneity of I 2 =80% and P=0.03. There was no statistically significant difference in the time to discharge when compared to the control group (mean difference of -2.12 {95% CI: -4.83 to 0.59; P=0.13}) and considerable heterogeneity (I 2 =95% and P<0.001).When compared to the control group, ABP did not provide any statistically significant difference in the risk ratio for infection (1.18 {95% CI: 0.52 to 2.65; P=0.70} and moderate heterogeneity {I 2 =33% and P=0.20}), pain (1.18 {95% CI: 0.52 to 2.65; P=0.70} and moderate heterogeneity {I 2 =33% and P=0.20}), and fever (0.54 {95% CI: 0.27 to 1.10; P=0.09} and no heterogeneity {I 2 =0% and P=0.50}).Our study concludes that using ABP caused a statistically significant decrease in the time to air leak cessation when compared to the control group. However, the procedure does not provide a statistically significant difference in the time to discharge from the hospital when compared to conservative treatment. Similarly, there was no statistically significant difference in the risk ratio for complications such as infection, pain, and fever when compared to conservative management. More studies need to be conducted to fully understand the efficacy and safety of ABP in the management of PALs.

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The effectiveness of blood amount used in pleurodesis to prevent prolonged air leakage

Cited by 6 publications

References 16 publications

Assessment and review of treatment for secondary spontaneous pneumothorax using medical thoracoscopy-assisted argon plasma coagulation in association with autologous blood pleurodesis

Assessment and review of treatment for secondary spontaneous pneumothorax using medical thoracoscopy-assisted argon plasma coagulation in association with autologous blood pleurodesis

Effectiveness of the polyglycolic acid patch in preventing prolonged air leakage after pulmonary decortication

The Efficacy and Safety of Autologous Blood Patch for Persistent Air Leaks: A Systematic Review and Meta-Analysis

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