User-friendly rehabilitation exercise devices can enhance health and quality of life through the convergence of information communication and medical technology. The development of rehabilitation exercise devices accessible to individuals with disabilities is important. We aimed to investigate the convenience, safety, and effectiveness of the developed rehabilitation exercise device for individuals with disabilities. A usability evaluation of the developed rehabilitation exercise device was conducted with five rehabilitation exercise experts and six athletes with disabilities using a questionnaire, the reliability of the revised questionnaire was <i>r</i>= 0.87. Qualitative analysis was conducted using semistructured interviews following the testing of the upper limb rehabilitation exercise device by the two user groups. In the usability evaluation survey of the developed rehabilitation exercise device, the results were very positive, with an overall score of 4.25 out of 5. The highest score was assigned to the convenience of the device, followed by the effectiveness of the exercise and the safety of the device. The developed rehabilitation exercise device allows for three types of strength improvement exercises, including isometric, isokinetic, and isotonic exercises, all within a single device. Given that it is constructed with a wire system, it can be adapted to various exercise methods, depending on the type of disability. The device can be used by both nondisabled and disabled individuals, allowing for various exercise methods. The evaluation results indicate that the proposed device is highly versatile and practical.