The Effectiveness of D-Chiro Inositol Treatment in Gestational Diabetes

Biase, Nicolina Di; Martinelli, Monica; Florio, Valeria; Meldolesi, C.; Bonito, Marco

doi:10.4172/2572-5629.1000131

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…However, these dosages are not currently allowed for supplementation. Furthermore, no side effects were observed in patients receiving intervention with DCI (27.5 up 500 mg/day) in the clinical studies available …”

Section: Inositol Safetymentioning

confidence: 92%

“…To date, three studies reported the effects on metabolic parameters of supplementation with DCI alone during pregnancy. Di Biase et al observed the effects of a supplementation with 1 g of DCI on 137 pregnant women diagnosed with GDM after the 24th week of gestation. Women were randomized to receive either DCI 500 mg twice a day or no supplement.…”

Section: Clincal Effects Of D‐chiro‐inositol Supplementationmentioning

confidence: 99%

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Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Formoso

Baldassarre

Ginestra

et al. 2019

Diabetes Metabolism Res

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Summary Pregnancies complicated by diabetes have largely increased in number over the last 50 years. Pregnancy is characterized by a physiologic increase in insulin resistance, which, associated with increased oxidative stress and inflammations, could induce alterations of glucose metabolism and diabetes. If not optimally controlled, these conditions have a negative impact on maternal and foetal outcomes. To date, one can resort only to diet and lifestyle to treat obesity and insulin resistance during pregnancy, and insulin remains the only therapeutic option to manage diabetes during pregnancy. However, in the last years, in a variety of experimental models, inositol and antioxidants supplementation have shown insulin‐sensitizing, anti‐inflammatory, and antioxidant properties, which could be mediated by some possible complementary mechanism of action. Different isomers and multiple combinations of these compounds are presently available: Aim of the present review article is to examine the existing evidence in order to clarify and/or define the effects of different inositol‐ and antioxidant‐based supplements during pregnancy complicated by insulin resistance and/or by diabetes. This could help the clinician's evaluation and choice of the appropriate supplementation regimen.

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Section: Inositol Safetymentioning

confidence: 92%

Section: Clincal Effects Of D‐chiro‐inositol Supplementationmentioning

confidence: 99%

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Formoso

Baldassarre

Ginestra

et al. 2019

Diabetes Metabolism Res

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“…Recent literature has provided insight into the use of different stereoisomers of inositol or their combination in GDM treatment [2,38], showing an improvement in fetal growth, glycemic control (post-prandial glycemia and insulin doses), and maternal weight gain in women who received DCI 500 mg twice a day vs placebo [38]; remarkably, a significant reduction in HOMA-IR and a lower need for intensified insulin therapy in women exposed to MI and MI plus DCI (2) have also been demonstrated. In a pilot case-control study, Pintaudi et al [3] found lower mean glucose levels and an improvement in glucose variability after MI treatment in women affected by GDM, suggesting that MI supplementation can be a useful strategy for treating GDM.…”

Section: Inositol Supplementation and Gdm Treatmentmentioning

confidence: 99%

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

et al. 2022

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There is growing interest in the potential role of different stereoisomers of inositol or their combination as well as probiotics supplementation in healthy glucose metabolism during pregnancy and in promoting offspring health. The aim of this review is to clarify the effects of several inositol and probiotics-based supplements in the prevention and treatment of gestational diabetes (GDM). Moreover, we will discuss the epigenetic aspects and their short- and long-term effects in response to probiotic intervention as well as the possible implications of these findings in guiding appropriate supplementation regimens in pregnancy.

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“…The effect of MI and DCI was evaluated in the population of pregnant women diagnosed with gestational diabetes in mono-formulations or in combination. It was found that there is a significant beneficial effect on metabolic factors and reduction of IR in pregnant women diagnosed with gestational diabetes, and according to the results of the study, it has been shown that DCI has a more significant effect than MI [29,30]. The choice of medical treatment including inositols depends on undelaying endocrinological and metabolic disorders and treatment goals.…”

Section: Treatment Of Reproductive Disorders With Inositolsmentioning

confidence: 95%

Inositols in the Treatment of Polycystic Ovary Syndrome in Reproductive Age

Smiljan Severinski,

Marton,

Radojčić Badovinac

2024

Obstetrics and Gynecology

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Polycystic ovary is part of an endocrine syndrome in which different pathophysiological mechanisms lead to a similar reproductive outcome: anovulation, irregularity of the menstrual cycle, and infertility. Hormonal and metabolic disorders are associated with reproductive adverse outcomes, which represent a vicious circle with dysfunctional ovaries. Hyperandrogenemia, disorder of carbohydrate metabolism, and sex hormone synthesis led to reproductive abnormalities. One of the most crucial questions still remains, whether the polycystic ovary is the cause or the consequence of all known disorders. Inositols are in the treatment of PCOS capable of restoring ovulation with the impact on the carbohydrate metabolism, by increasing the sensitivity of cells to insulin, which releases the sex hormones-binding protein and improves hyperandrogenemia. Nine stereoisomers of inositol are known, myo-inositol and chiro-inositol are the most studied in the reproductive age. By normalizing the level of androgens in the blood, the growth of and the balance of sex hormones is established. A variety of metabolic pathways of these molecules are recognized in different tissues, such as fat, muscle, or ovarian tissue. Still, it is not clear which isomer has better reproductive or metabolic effects, and there are controversies about their effectiveness in the treatment of reproductive disorders.

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The Effectiveness of D-Chiro Inositol Treatment in Gestational Diabetes

Abstract: Background: Purpose of this study was to evaluate the role of D-chiro-inositol (DCI) in the metabolic control of women affected by gestational diabetes mellitus (GDM) and to examine the impact on pregnancy and fetal outcome.

Cited by 7 publications

References 17 publications

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

Inositols, Probiotics, and Gestational Diabetes: Clinical and Epigenetic Aspects

Inositols in the Treatment of Polycystic Ovary Syndrome in Reproductive Age

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