The Effectiveness of Ethyl Acetate Extract of Sungkai Leaves (Peronema Canescens Jack.) Against Blood Glucose Levels in Alloxan-Induced Male Mice

Abstract

This research aims to test antidiabetic using alloxan induction on mice test animals. The type of research used is experimental, which includes sampling, sample determination. Extract preparation with ethyl acetate solvent, extract characteristics test and simplicia, extract and simplicia screening test. Antidiabetic testing was carried out using male mice as test animals. Screening tests for the presence of alkaloids, flavonoids, tannins, saponins, steroids, and glycosides for the anti-diabetic test of Sungkai leaves were carried out using alloxan induction in mice. With initial KGD 90-120 mg/dl. Extract concentrations were 100 mg/kg, 200 mg/kg and 300 mg/kg with negative control CMC Na 0.5% and metformin positive control 65 mg/kg. The most effective decrease in mice blood glucose on days 3, 7, 10 and 14 was at an extract concentration of 300 mg/kg bw with a decrease of 114 mg/dl. Based on the results of the ANOVA statistic Fcount 208.813> Ftable 2.87 so H0 is rejected, there is a significant decrease in blood sugar in mice. The results of the anti-diabetic test of the ethyl acetate extract of Sungkai leaves at a dose of 300 mg/kg body weight had an anti-diabetic effect on male mice after alloxan induced on the 14th day with an average of 114 being the most effective in reducing the male mice's KGD.

Extraction of Sungkai (Peronema cannescens Jack) leaves, Antioxidant Activity Test and Its Nanoemulsion Formulation

“…The leaves and roots of sungkai have also long been used as traditional medicine in the Dayak Tunjung tribe as a medicine for fever, diuretic and rheumatic pain, and the Lembak Empat tribe in Bengkulu still uses the young leaves of sungkai to maintain health, treat high fever and malaria [1]. Currently, sungkai research focuses on leaves as an extract which has potential as an antipyretic [2] anti-inflammatory [3,4], antioxidant [5][6][7][8], antibacterial [9][10][11], Antihyperuricemia [12], anticancer [13,14], and antidiabetic [15,16].…”

Effects of Ethanol Extract of Sungkai (Peronema canescens Jack.) on Fertility of Female Wistar Mice (Mus musculus L.)

“…The results of the phytochemical test on Sungkai revealed that the plant contains various secondary metabolites, including alkaloids, steroids, terpenoids, tannins, and saponins. 6 Another research shows that the ethanol extract of sungkai leaf also contains phenolics, anthraquinones, and flavonoids. Flavonoids are polyphenols found in many plants.…”