The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial

Sihombing, Aaron Tigor; Prabharani, Diaswara; Lukman, Kiki; Sudjud, Reza Widianto

doi:10.1016/j.amsu.2022.104865

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…47 Therefore, the amelioration of EDSS scores after ginger supplementation may be the reason for the betterment of physical QoL in this trial. Moreover, supplementation with ginger has been shown to reduce symptoms of anxiety and depression in human 48,49 and animal studies. 50,51 Therefore, the amelioration of psychological QoL in this study may be caused by the anti-anxiety and anti-depressant effects of ginger.…”

Section: Discussionmentioning

confidence: 99%

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

et al. 2023

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Section: Discussionmentioning

confidence: 99%

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

et al. 2023

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Investigating the Effect of Ginger as an Adjunctive Treatment along with SSRIs to Reduce Anxiety in Patients with GAD: A Clinical Trial Study

Ataei,

Jahangard,

Anaraki

et al. 2025

CPRR

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Introduction: Generalized anxiety disorder (GAD) is characterized by exaggerated anxiety without any apparent cause of concern. The primary treatment of this disorder is usually SSRIs, which have many digestive side effects and do not provide complete treatment for the patient. The use of non-pharmacological methods may help reduce these complications. Therefore, the present study was conducted to investigate the effect of ginger as an adjunctive therapy along with SSRIs to reduce anxiety in patients with GAD. Materials and Methods: In this double-blind, controlled clinical trial study, a total of 80 patients with GAD were randomly assigned into two groups. For the intervention group, at the same time as SSRI drug, two 500-mg ginger capsules were used daily while in the control group, two starch capsules were used daily as a placebo along with SSRI. Data collection tools were Hamilton's anxiety questionnaire and a gastrointestinal symptom severity scale. Data were collected before the intervention and after the 12-week intervention. Results: There was no significant difference between the intervention and control groups in terms of average anxiety and severity of digestive symptoms before the intervention (P>0.05), but there was a significant difference between the groups after the intervention (P<0.05). Also, the average scores of anxiety and severity of gastrointestinal symptoms in the intervention group increased significantly from the beginning of the intervention to the follow-up (intragroup difference) (p<0.05). Conclusion: The results of the study showed that the use of ginger along with SSRIs reduced anxiety and released the severity of gastrointestinal symptoms in patients with GAD. In addition, in this study, it was found that ginger, along with SSRIs, can have beneficial effects on indigestion, diarrhea, and nausea in patients with GAD. However, these findings require more extensive research.

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Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

Shahrajabian

Kuang

Cui

et al. 2023

COC

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Introduction: Traditional Chinese medicine is an ancient system of wellness and health that has been used in almost all countries of the world, specially in Asia for thousands of years. Method: The growth, development, final yield and chemical compounds of medicinal plants can be negatively influenced by different kinds of biotic and abiotic stresses. Abiotic stress signals are chemical stress (Mineral salts, heavy metal, aerosols, gaseous toxins, pesticides, and pollutants), salinity (salt), temperature (Heat, cold), radiation (Ionisation radiation, light and UV), water (Flooding, drought) and mechanical stress (Submergence, wind, soil movement). Relevant literature has been obtained using the keywords “Traditional Chinese Medicine”, “Abiotic Stress”, “Biotic Stress”, “Ginseng”, “Ginger”, “Goji berry”, “Astragalus”, “Ginkgo”, “Artemisia annua L.”, “LC-MS”, “GC-MS”, and “NMR” in scientific information, namely “Web of Science”, “PubMed”, “SciFinder”, and “Elsevier”. Some of the plants’ secondary metabolites under different growth conditions are Camptothecin (Camptotheca acuminata), Capsaicin (Capsicum sp.), Rosmarinic acid (Salvia miltiorrhiza), Codeine (Papaver somniferum), Resveratrol (Grapes, groundnut), Artemisinin (Artemesia annua), Allicin (Allium sativum), Rohitukine (Dysoxylum binectariferum), Stevioside (Stevia rebaudiana), Andrographolide (Andrographis paniculata), Saikosaponins (Bupleurum chinense), Sennosides (Cassia augustifolia), Rutin (Dimorphandra mollis), Valepotriates (Valeria species), Indole alkaloids (Catharanthus roseous), and Furanocoumarins (Bituminaria bituminosa). Result: The aim of this article is a survey of active chemical compounds and metabolic changes of some of the most important medicinal plants in traditional Chinese medicine (TCM) in both abiotic and biotic stresses. Conclusion: Future research is needed to evaluate the effects of biotic and abiotic stresses on chemical compounds and active metabolites of medicinal plants specially traditional Chinese medicine, and more surveys on the roles of LC-MS, GC-MS and NMR techniques for a better understanding of chemical components of medicinal plants.

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The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial

Cited by 3 publications

References 19 publications

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

Investigating the Effect of Ginger as an Adjunctive Treatment along with SSRIs to Reduce Anxiety in Patients with GAD: A Clinical Trial Study

Metabolic Changes of Active Components of Important Medicinal Plants on the basis of Traditional Chinese Medicine under Different Environmental Stresses

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