The effectiveness of hyperbaric oxygen treatment in tracheal reconstruction with auricular cartilage grafts (experimental study)

Güngör, Atila; Poyrazoğlu, Ethem; Cincik, Hakan; Sali, Murat; Candan, Hasan

doi:10.1016/s0196-0709(03)00091-7

Cited by 19 publications

(24 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HBO improved the area of survival of reattached auricular composite grafts in New Zealand rabbits [15,16]. In their animal study on tracheal reconstruction with auricular cartilage grafts and HBO as an adjuvant, Gungor et al [14] found less inflammation, fibrosis, and necrosis, and earlier neovascularisation. There was no significant difference between the control and study groups.…”

Section: Discussionmentioning

confidence: 97%

Effect of hyperbaric oxygen on survival of composite grafts in rats

Fodor

Ramon

Meilik

et al. 2006

Scandinavian Journal of Plastic and Reconstructive Surgery and

View full text Add to dashboard Cite

Most treatment with hyperbaric oxygen (HBO) in plastic surgery is for wounds, burns, crush injuries, and infections. We aimed to find out if HBO increases the survival of composite grafts in rats. Twenty Sprague-Dawley rats were randomly assigned to two equal groups (treatment and control). A template 30 x 30 mm was placed on the skin and a composite graft taken from the upper back was harvested and then resutured to the fascia in situ. The treated group was placed in a hyperbaric chamber set at 202 kPa and 100% oxygen for 90 minutes daily for two weeks. Control animals were given no treatment. After death the mean surviving internal surface area of the graft was 372.5 (117.9) mm2 in the control group and 561.3 (85.7) mm2 in the experimental group (p=0.001). Treatment with HBO improved the surviving area of composite grafts in rats, and the beneficial effect was prominent only on the inner surface of the graft.

show abstract

Section: Discussionmentioning

confidence: 97%

Effect of hyperbaric oxygen on survival of composite grafts in rats

Fodor

Ramon

Meilik

et al. 2006

Scandinavian Journal of Plastic and Reconstructive Surgery and

View full text Add to dashboard Cite

show abstract

“…In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation . Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

Section: Discussionmentioning

confidence: 99%

“…We also found significant upregulation of hypoxia-inducible genes in donor airways, with expression of VEGFA, KDR, and HMOX1 being associated with prolonged respiratory failure, prolonged hospitalization, extensive airway necrosis, and CAS. 13 In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, [30][31][32] and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation. [33][34][35][36] Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

Section: Discussionmentioning

confidence: 99%

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Mahmood

Kraft

Glisinski

et al. 2016

Clinical Transplantation

View full text Add to dashboard Cite

Background Central airway stenosis (CAS) is common after lung transplantation and causes significant post-transplant morbidity. It is often preceded by extensive airway necrosis, related to airway ischemia. Hyperbaric oxygen therapy (HBOT) is useful for ischemic grafts and may reduce the development of CAS. Methods The purpose of this study was to determine whether HBOT could be safely administered to lung transplant patients with extensive necrotic airway plaques. Secondarily, we assessed any effects of HBOT on the incidence and severity of CAS. Patients with extensive necrotic airway plaques within 1–2 months after lung transplantation were treated with HBOT along with standard care. These patients were compared with a contemporaneous reference group with similar plaques who did not receive HBOT. Results Ten patients received HBOT for 18.5 (interquartile range, IQR 11–20) sessions, starting at 40.5 (IQR 34–54) days after transplantation. HBOT was well tolerated. Incidence of CAS was similar between HBOT-treated patients and reference patients (70% vs 87%, respectively; P=.34), but fewer stents were required in HBOT patients (10% vs 56%, respectively; P=.03). Conclusions This pilot study is the first to demonstrate HBOT safety in patients who develop necrotic airway plaques after lung transplantation. HBOT may reduce the need for airway stent placement in patients with CAS.

show abstract

“…Neovascularization is important in helping fight infection as well as in the later phases of wound repair as it facilitates the migration of fibroblasts and epithelial cells that continue the healing process. Improved angiogenesis with HBOT has been associated with improvements in healing in such diverse experimental animal models as burns, 85 cartilage and skin grafts, 17,86 dermal wounds, 82,85,87 and bone healing 88 …”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Hyperbaric oxygen therapy. Part 2: application in disease

Edwards¹

2010

J Vet Emergen Crit Care

View full text Add to dashboard Cite

There is a substantial body of literature that has examined the adverse and beneficial effects of HBOT in animal models. As technology becomes more readily available to clinical practice and more clinical trials are performed to define its effectiveness, HBOT may be considered as an additional therapeutic option in many conditions including select problem wounds, spinal cord injury, and cerebral ischemic injury. Understanding the mechanisms by which HBOT exerts its effects will help guide research and use of the modality in clinical patients.

show abstract

The effectiveness of hyperbaric oxygen treatment in tracheal reconstruction with auricular cartilage grafts (experimental study)

Cited by 19 publications

References 11 publications

Effect of hyperbaric oxygen on survival of composite grafts in rats

Effect of hyperbaric oxygen on survival of composite grafts in rats

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Hyperbaric oxygen therapy. Part 2: application in disease

Contact Info

Product

Resources

About