The purpose of this study is to find a general picture of quality of life in students and to find the relationship between quality of life and burnout. Quality of life of students explains the level of satisfaction of student life and is a predictor of academic success. This relates to evaluating the satisfaction of life domains (health, self-esteem, spiritual, money or standards of living, work, play, helping, friendship, sibling relationships, spiritual, learning, creativity, family, neighborhood and community). Burnout is defined as a condition where individuals experience emotional exhaustion, depersonalization and reduce self-efficacy. The study used a cross-sectional design with a sample of 469 students. Data was collected using Quality of Life Inventory and Student Burnout Scale. Data analysis techniques used the Pearson correlation method to determine the relationship between quality of life and burnout among students. The F-Test technique is used to compare differences in quality of life based on gender. The results showed no significant difference in the quality of life of men and women. The highest life domain is family. While the lowest life domain is love, the relationship between quality of life and burnout was found to be negatively correlated. The burnout dimension consisting of emotional exhaustion, depersonalization and reducing academic efficacy was found to be negatively correlated with quality of life, based on the results of the study needed for the development of counseling interventions to improve the quality of life to reduce burnout in students.