The Effectiveness of Saireito, a Traditional Japanese Herbal Medicine, in Reducing Postoperative Edema after Acquired Ptosis Surgery: A Prospective Controlled Trial

Morimoto, Naoki; Kakudo, Natsuko; Mitsui, Toshihito; Kuro, Atsuyuki; Ueda, Yuko; Hihara, Masakatsu; Tanaka, Yoshihito; Ozaki, Yujiro; Suzuki, Kenji; Kusumoto, Kenji

doi:10.1155/2018/4742305

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…Other miscellaneous supplements demonstrated beneficial effects in patients undergoing craniofacial surgery. Saireito pills, a combination of 12 medicinal herbs, reduced incidence of edema in blepharoplasty patients when given postoperatively 16 . Postoperative topical olive oil application in sinonasal surgery patients resulted in significantly less crusting, improved wound healing, and reduced self-reported pain scores compared with saline application 17 .…”

Section: Resultsmentioning

confidence: 98%

“…Saireito pills, a combination of 12 medicinal herbs, reduced incidence of edema in blepharoplasty patients when given postoperatively. 16 Postoperative topical olive oil application in sinonasal surgery patients resulted in significantly less crusting, improved wound healing, and reduced self-reported pain scores compared with saline application. 17 Preoperative use of yunnan baiyao capsules for bimaxillary orthognathic surgery patients resulted in a significant reduction in intraoperative blood loss compared with the placebo group.…”

Section: Beneficial Healing Effectsmentioning

confidence: 97%

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Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Spielman

Epstein

Jabori

et al. 2020

Journal of Craniofacial Surgery

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Background: In the United States, the use of herbal supplements on a regular basis ranges from 32% to 97%. Prevalence of supplement use is particularly elevated after facial surgery. It has been reported as high as 50%. Unfortunately, there is a paucity of literature on the dietary use of supplements. They are not regulated by the FDA. Often, they are not reported by patients. This study examines the role of dietary supplements as adjuncts to healing in craniofacial and facial aesthetic surgeries. Methods: A comprehensive literature review was conducted using MEDLINE, PubMed, and EMBASE. Databases were screened for papers describing the use of supplements in craniofacial procedures in adult patients using relevant search terms. Data on criteria, outcomes, and patient satisfaction were collected. Results: A total of 19 articles were selected from the 806 identified. Fifteen different supplements or combinations of supplements have been studied for use in facial surgeries. Of these 15 supplements, the following demonstrated potential healing benefits: dry ivy leaf extract, Nazalzem ointment (vitamin A and dexpanthenol), combination nasal sprays (phospholipids, fatty acids, vitamin A, and vitamin E), Saireito pills, topical olive oil, yunnan baiyao, melilotus extract, arnica, and combination arnica and ledum. Arnica is the most commonly studied supplement in a variety of facial operations. Conclusions: There is ample evidence to support a role for the use of certain dietary supplements to optimize wound healing in craniofacial and facial aesthetic surgery. Controlled diet and use of appropriate supplements may have a synergistic beneficial effect on wound healing following craniofacial surgery. However, there is a need for additional reporting to allow for the creation of stronger guidelines and increased patient screening, reporting, and compliance.

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Section: Resultsmentioning

confidence: 98%

Section: Beneficial Healing Effectsmentioning

confidence: 97%

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Spielman

Epstein

Jabori

et al. 2020

Journal of Craniofacial Surgery

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“…30 Previous investigations have reported that Shosaikoto has potential application as an anti-inflammatory drug by inhibiting proinflammatory cytokines and promoting endogenous enhancement of steroid secretion. 18,31 Therefore, Saireito has both antiinflammatory and water utilization benefits.…”

Section: Byakujutsu Saireitomentioning

confidence: 99%

“…17 Saireito is a combination of Goreisan and Shosaikoto and has both the hydragogue effect of Goreisan and the anti-inflammatory action of Shosaikoto. 18 Some case series and retrospective studies have shown that Goreisan and Saireito reduced the postoperative recurrence of CSDH. 14,15,19,20 Recently, 3 prospective and randomized studies have been conducted to investigate whether Goreisan reduces the recurrence rate of CSDH.…”

mentioning

confidence: 99%

The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study

Matsumoto,

Miyata

et al. 2023

Neurosurgery

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BACKGROUND AND OBJECTIVES: Chronic subdural hematoma (CSDH) sometimes recurs after surgical treatment and requires reoperation. In Japan, Japanese herbal medicines (Kampo), such as Goreisan and Saireito, have been used as adjunctive therapies to prevent the recurrence of CSDH. However, no prospective randomized study has proven the efficacy of Kampo medicine in all patients. To investigate whether Goreisan and Saireito reduce the postoperative recurrence of CSDH in a prospective randomized study. METHODS: Between April 2017 and July 2019, a total of 118 patients who underwent initial burr hole surgery for CSDH were randomly assigned to the following 3 groups: (1) Goreisan for 3 months (Group G), (2) Saireito for 3 months (Group S), and (3) no medication (Group N). The primary end point was symptomatic recurrence within 3 months postoperatively, and the secondary end point was complications associated with the administration of Kampo medicine. RESULTS: Among 118 patients, 114 (Group N, n = 39; Group G, n = 37; and Group S, n = 38) were included in our analysis. In this study, byakujutsu (containing Atractylodes rhizome) Goreisan and Saireito were used, unlike other prospective randomized studies in which sojutsu (containing Atractylodes lancea rhizome) Goreisan was used. The overall recurrence rate was 11.4% (13/114: 10 for Group N, 2 for Group G, and 1 for Group S). The recurrence rate of Group G was significantly lower than that of Group N (5.4% vs 25.6%; P = .043). The recurrence rate of Group S was also significantly lower than that of Group N (2.6% vs 25.6%; P = .02). No patients developed complications associated with the administration of Kampo medicine. CONCLUSION: This is the first study to show that Kampo medicine reduced the recurrence rate of CSDH in an overall population. This study demonstrated that byakujutsu Goreisan and Saireito may have favorable effects, unlike other studies, because byakujutsu has stronger anti-inflammatory activity than sojutsu.

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“…Saireito has been used in the treatment of chronic kidney disease, diarrhea, acute gastritis, and various edematous disorders, such as subdural hematoma, chronic lymphedema, cirrhosis, and general edema. Saireito has also widely been used to treat various inflammatory diseases, such as rheumatoid arthritis [ 6 , 7 ]. Recently, herbal medications have been attracting attention for their effectiveness in circulatory disease; however, the association between the use of herbal medication and pleural effusion has not been well documented.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Saireito, a Traditional Japanese Kampo Herbal Medication, on Pacemaker-Related Pleural Effusion: A Case Report

et al. 2021

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Patient: Female, 71-year-old Final Diagnosis: Pacemaker related pleural effusion Symptoms: Dry cough Medication:— Clinical Procedure: — Specialty: Cardiology • General and Internal Medicine Objective: Unusual or unexpected effect of treatment Background: Post-cardiac injury syndrome, including pleural effusion as a delayed complication of permanent pacemaker implantation, has rarely been reported. To resolve pleural effusion, prolonged chest tube placement is often required. Anti-inflammatory agents combined with diuretics are also often prescribed. Saireito, a Japanese herbal medication, which is a combination of Goreisan and Shousaikoto, has both anti-inflammatory and water-modulation properties and has been used for edema (lymph edema, cerebral edema) and inflammation (chronic nephritis). Case Report: We describe a 71-year-old woman with a history of syncope and bradycardia who underwent dual permanent pacemaker implantation (placed in the right chest because of a persistent left superior vena cava) without complications. Two months later, she came to the hospital as an outpatient with a dry cough, and was diagnosed with right-sided pleural effusion. A pleural fluid analysis revealed exudative effusion, according to Light’s criteria. The fluid was negative for infectious etiology. Chest X-ray, computed tomography, and echocardiography revealed no signs of pericardial effusion or perforation of the pacemaker lead to outside the heart. The pleural effusion persisted despite use of anti-inflammatory medication for several weeks and diuretics for a short period. Saireito was administered with good response; the pleural effusion resolved completely and there was no deterioration of renal function. Conclusions: The present case highlights the clinical significance of Saireito as an effective therapeutic agent for late-onset pacemaker-related pleural effusion, without adverse effects such as renal dysfunction.

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The Effectiveness of Saireito, a Traditional Japanese Herbal Medicine, in Reducing Postoperative Edema after Acquired Ptosis Surgery: A Prospective Controlled Trial

Cited by 8 publications

References 21 publications

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

Healing Adjuncts in Craniofacial Surgery: Review of Dietary Vitamins and Supplements

The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study

Effectiveness of Saireito, a Traditional Japanese Kampo Herbal Medication, on Pacemaker-Related Pleural Effusion: A Case Report

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