The effectiveness of surface disinfectants and a micellic H2O2 based water disinfectant on Candida auris

Zatorska, Beata; Moser, Doris; Diab-Elschahawi, Magda; Ebner, Julia; Lusignani, Luigi Segagni; Presterl, Elisabeth

doi:10.1016/j.mycmed.2021.101178

Cited by 16 publications

(12 citation statements)

References 32 publications

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“…Secondly, regardless C. auris had been previously described as displaying different resistance to H 2 O 2 in comparison to C. albicans [31][32][33], such was not the case in this study. In fact, a similar resistance pattern was found for the three yeast species, as demonstrated by the non-signi cant differences in MIC values.…”

Section: Discussioncontrasting

confidence: 52%

Does repeated exposure to hydrogen peroxide induce Candida auris resistance?

Cobrado

Ricardo

Ramalho

et al. 2022

Preprint

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Background In order to minimize environmental colonization by microorganisms that may persist and thrive in healthcare settings, thus reducing healthcare-associated infections (HAIs), new insights over already known biocides are certainly of relevance. Although the efficacy of hydrogen peroxide (H2O2) against the emergent yeast Candida auris is moderately documented, concerns over the potential induction of resistance after repeated exposure do persist. The main objective of the present study was to evaluate the hypothetical induction of Candida auris resistance following 30 days of consecutive exposure to lethal and sublethal concentrations of H2O2. Furthermore, the authors aimed to elucidate about the rank of efficacy of H2O2 against C. auris comparing to other Candida species and whether different strains of C. auris may display different susceptibility to H2O2. Methods During the induction of resistance assays, both type strains and clinical isolates of Candida auris, Candida albicans and Candida parapsilosis were exposed repeatedly to defined concentrations of H2O2, for 30 days. Results After that period, no significant differences were found when comparing the minimal inhibitory concentration values of H2O2 in case of the induced strains versus each respective control. Moreover, H2O2 displayed similar effectiveness against all the tested Candida species and no differences were demonstrated among the distinct strains of C. auris. Conclusions The adoption of H2O2 solutions in routine protocols in order to promote disinfection standards against Candida auris, improving patient safety and reducing healthcare costs, is certainly welcomed.

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Section: Discussioncontrasting

confidence: 52%

Does repeated exposure to hydrogen peroxide induce Candida auris resistance?

Cobrado

Ricardo

Ramalho

et al. 2022

Preprint

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“…For surface disinfection, products based on QAC should be avoided, as available data suggest insufficient efficacy on C. auris (and also other Candida species). In contrast, disinfectants that contain relevant alcohol components in addition to QAC can be expected to be effective 47‐51 . In case of doubt, a switch to alcohol‐based disinfectants should be made.…”

Section: Recommendationsmentioning

confidence: 99%

“…In contrast, disinfectants that contain relevant alcohol components in addition to QAC can be expected to be effective. [47][48][49][50][51] In case of doubt, a switch to alcohol-based disinfectants should be made. Daily disinfecting cleaning of the patient's room is routinely implemented at intensive care units and is recommended for normal wards caring for a C. auris colonised / infected patient.…”

Section: Test All Patients In the Affected Organisational Unit For C ...mentioning

confidence: 99%

Expert recommendations for prevention and management of Candida auris transmission

Aldejohann

Wiese-Posselt

Gastmeier

et al. 2022

Mycoses

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Candida auris was first described as a causative agent of otomycosis in Japan in 2009. 1 Since then, the species has spread globally. C. auris has been isolated from various clinical materials, both as a causative agent of invasive infections and as a coloniser. 2-5 Initially, identification of C. auris in the clinical laboratory was highly problematic because the new species was not included in evaluation databases for diagnostic procedures such as biochemical tests and mass spectrometry (MALDI-TOF). 6 In the meantime, identification by MALDI-TOF is straightforward if up-to-date technologies and databases are used. 7 Consequently, a German national ring trial showed that 85% of 233 participating laboratories succeeded in correctly identifying C. auris already in 2018, (personal communication G. Haase, Aachen, Germany). However, other European quality control trials show less reassuring results recently. 8,9 As an alternative to MALDI-TOF,

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“…For cleaning inert material, quaternary ammonium disinfectants should be avoided because they have been shown to be ineffective against C. auris (81). In contrast, sodium hypochlorite, peracetic acid, and hydrogen peroxide have been experimentally proven to reduce the fungal load as measured by CFU counting by 5.0 to 6.0 Log10 (81,82). Disposable wipes soaked with sodium hypochlorite must be preferred for cleaning surfaces.…”

Section: Prevention: Which Prophylactic Means In Healthcare Facilities?mentioning

confidence: 99%