The Effectiveness of Systemic Antibiotics in Preventing Postoperative, Intraabdominal Adhesions in an Animal Model

Öncel, Mustafa; Kurt, Necmi; Remzi, Feza H.; Sensu, Sibel; Vural, Selahattin; Gezen, Cem; Çinçin, Tarık Gandi; Olcay, Ergin

doi:10.1006/jsre.2001.6245

Cited by 39 publications

(31 citation statements)

References 13 publications

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“…Thus, the intraperitoneal administration of tenoxicam combined with other medications, such as systemic antibiotics, may reduce the severity of adhesions. 41 Further experiments are necessary to determine the mechanism(s) of action of tenoxicam in bacterial peritonitis.…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal Tenoxicam to Prevent Abdominal Adhesion Formation in a Rat Peritonitis Model

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Intraperitoneal Tenoxicam to Prevent Abdominal Adhesion Formation in a Rat Peritonitis Model

et al. 2006

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“…The relationship between the intra-abdominal infections and serious adhesions has been shown, and a previous study from our institution has revealed that the use of antibiotics may decrease the postoperative adhesions in rats. 15 Taurolidine is mainly recommended as an antiseptic product in case of intraperitoneal sepsis (i.e., for washing the cavity after the drainage of an abdominal abscess) and has been experimentally used for reducing intraperitoneal tumor growth. 16 Finally, experimental studies have demonstrated that the product may be used as an antiadhesive, probably as a consequence of its antimicrobial and antiproliferative effects.…”

mentioning

confidence: 99%

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Bahadir¹,

Öncel²,

Kement³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…Several approaches have been used to prevent adhesions, including antiinflammatory agents (5), antibiotics (6), and both chemical (7,8) and physical (9,10) barriers. Unfortunately, none of these measures has proven uniformly effective under all surgical conditions.…”

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confidence: 99%

A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

Reed

Fruin

Gower

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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Fibrous adhesions remain a major sequela of abdominal surgery. The proinflammatory peptide substance P (SP), known to participate in inflammatory events, may play a key role in adhesion formation. This hypothesis was tested by using an antagonist, CJ-12,255 (Pfizer), that blocks the binding of SP to the neurokinin 1 receptor (NK-1R). Adhesion formation was surgically induced in the peritoneum of rats receiving daily doses of the NK-1R antagonist (NK-1RA; 5.0 or 10.0 mg͞kg per day) or saline. On postoperative day 7, both the low and high doses of NK-1RA significantly (P < 0.05) reduced adhesion formation by 45% and 53%, respectively, compared with controls. Subsequently, the effect of NK-1RA administration on peritoneal fibrinolytic activity was investigated to determine a potential mechanism for SP action in the peritoneum. Samples were collected from nonoperated controls and from animals 24 h postsurgery that were administered either NK-1RA or saline. Fibrinolytic activity in peritoneal fluid was assayed by zymography, and expression of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1, both regulators of fibrinolytic activity, was assessed in peritoneal tissue and fluid by RT-PCR and bioassay, respectively. NK-1RA administration led to a marked (P < 0.05) increase in tPA mRNA levels in peritoneal tissue compared with nonoperated and saline-administered animals. Likewise, NK-1RA administration significantly (P < 0.05) increased tPA in the peritoneal fluid. These data suggest that activation of the NK-1R promotes peritoneal adhesion formation by limiting fibrinolytic activity in the postoperative peritoneum, thus enabling fibrinous adhesions to persist.

show abstract

The Effectiveness of Systemic Antibiotics in Preventing Postoperative, Intraabdominal Adhesions in an Animal Model

Cited by 39 publications

References 13 publications

Intraperitoneal Tenoxicam to Prevent Abdominal Adhesion Formation in a Rat Peritonitis Model

Intraperitoneal Tenoxicam to Prevent Abdominal Adhesion Formation in a Rat Peritonitis Model

Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

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