The effectiveness of Zataria extract mouthwash for the management of radiation-induced oral mucositis in patients: a randomized placebo-controlled double-blind study

Aghamohammadi, Azar; Moslemi, Dariush; Âkbari, Jafar; Ghasemi, Arash; Azadbakht, Mohammad; Asgharpour, Askari; Hosseinimehr, Seyed Jalal

doi:10.1007/s00784-017-2324-7

Cited by 30 publications

(17 citation statements)

References 28 publications

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“…This can be due to differences in the type of treatment regimen used to treat patients with different cancers in the mentioned study, while in the present study, colon cancer patients were treated with FOLFOX regimen. In a study conducted by Aghamohammadi et al in 2017 to determine the effect of Zataria multiflora extract on the prevention and reduction of oral mucositis in patients with head and neck cancer treated with local radiotherapy, they showed that the incidence of mucositis in the intervention group was significantly lower than that in the control group (25). The result of this study is inconsistent with the findings of the present study in terms of the mucositis incidence in the intervention and control groups.…”

Section: Discussioncontrasting

confidence: 99%

Comparative Study of the Effect of Licorice Root Extract Mouthwash and Combined Mouthwash on the Incidence and Severity of Chemotherapy-Induced Mucositis Symptoms in Colon Cancer Patients Admitted to Intensive Care Units

Sattari

Shariati

Maram

et al. 2019

Jundishapur J Chronic Dis Care

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Background: Colon cancer is the third leading cause of death globally, and mucositis is one of the complications of cancer treatment following drug therapy. Objectives: This study investigated the effect of licorice root extract mouthwash with combined mouthwash on the incidence and severity of chemotherapy-induced mucositis symptoms in colon cancer patients admitted to intensive care units (ICUs). Methods: In this clinical trial, 72 colon cancer patients were treated with chemotherapy. A purposive random sample of patients was divided into two groups of intervention (n = 36) and control (n = 36). Patients in the control group received routinely used combined mouthwash. However, the intervention group received licorice root extract 5% from the beginning of the treatment according to the researcher's plan. Then, the degree of mucositis and ulcer area were recorded on the first, third, and seventh days of treatment based on the WHO standard tool for measuring mucositis severity. Results: The intervention and control groups had no significant difference on the first, third, and seventh days of treatment in the incidence of mucositis (P = 0.554, P = 0.308, and P = 0.601, respectively) and the severity of mucositis (P = 0.357, P = 0.857, P = 0.607, respectively). Conclusions: There was no difference in the efficacy of combined mouthwash and licorice root extract mouthwash in the incidence and severity of mucositis. Due to the interest of many patients in the use of herbal compounds, licorice root extract mouthwash can be used as an alternative to combined mouthwash.

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Section: Discussioncontrasting

confidence: 99%

Comparative Study of the Effect of Licorice Root Extract Mouthwash and Combined Mouthwash on the Incidence and Severity of Chemotherapy-Induced Mucositis Symptoms in Colon Cancer Patients Admitted to Intensive Care Units

Sattari

Shariati

Maram

et al. 2019

Jundishapur J Chronic Dis Care

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“…Patients using the SN oil as a mouthwash had a significantly lower OM severity than those in the control group who are treated with a Magic mouthwash formula from weeks 3 to 7 of treatment. These results were in tune with many previously reported data about the efficacy of many natural compounds in the prevention and alleviation of RT or chemo-RT induced OM [16][17][18]. Many compounds have been tried to reduce or prevent RT-induced OM [19][20][21]; however, the clinical practice demonstrates various attitudes towards the use of an accepted medication for minimization and prevention of OM.…”

Section: Discussionsupporting

confidence: 86%

Anti-Inflammatory Effect of Nigella Sativa Oil on Chemoradiation-Induced Oral Mucositis in Patients With Head and Neck Cancers

Ameen¹,

Mohammed²,

Ahmed³

et al. 2019

Int J Curr Pharm Sci

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Objective: Oral mucositis (OM) is a common treatment-induced toxicity in patients undergoing radiation or chemoradiation for head and neck cancers (HNC). The study aims to evaluate the anti-inflammatory effect of Nigella sativa (NS) oil in radiation-or chemoradiation-induced OM in HNC patients. Methods:From Forty HNC patients were randomized to two groups, each of 20 patients. The first group was treated with NS oil mouthwash five times daily, while the second group was treated with the Magic mouthwash and served as a control. All patients received radiotherapy (RT) (60-70 Gy) in 30-35 fractions over 6-7 w with or without chemotherapy. Patients were evaluated once per week to estimate the severity and duration of OM and the salivary levels of IL-6 and TNF-α.Results: 70% of patients were men and the commonest tumor locations were larynx (47.5%) and pharynx (22.5%) classified as stages III or IV. NS oil significantly reduces RTOG grade and OM severity after 3-4 w of RT, attenuates the elevation in salivary IL-6 and TNF-α production after 3-5 w.Conclusion: Nigella sativa oil mouthwash have a potential anti-inflammatory activity that may be beneficial in minimizing or preventing radiationor chemoradiation-induced oral mucositis in patients with head and neck cancer.

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“…Aghamohammadi et al [ 12 ] demonstrated that a mouthwash based on Zataria extracts affected the incidence of grade 3–4 oral mucositis to a relative risk ratio of 0.432 and also had a significant effect on the patient’s pain symptomatology.…”

Section: Resultsmentioning

confidence: 99%

Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

et al. 2023

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Background: In the literature, among oral health prevention programs dedicated to cancer patients, a wide heterogeneity is evident. The purpose of this work is to analyze the available scientific evidence for the treatment of head and neck cancer (HNC) patients undergoing resective surgery and radiotherapy and to draw up a diversified oral hygiene protocol during oncological therapy. Methods: PubMed was used as database. Studies published from 2017 to September 2022 were analyzed. Studies investigating the effectiveness of the preventive procedures carried out by the dental professionals in HNC patients undergoing postoperative adjuvant therapy have been taken into account. Results: The application of the search string on PubMed allowed the selection of 7184 articles. The systematic selection of articles led to the inclusion of 26 articles in this review, including 22 RCTs, 3 observational studies, and 1 controlled clinical study. Articles were divided according to the debated topic: the management of radiation-induced mucositis, xerostomia, the efficacy of an oral infection prevention protocol, and the prevention of radiation-induced caries. Conclusions: Dental hygienists are fundamental figures in the management of patients undergoing oncological surgery of the maxillofacial district. They help the patient prevent and manage the sequelae of oncological therapy, obtaining a clear improvement in the quality of life.

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The effectiveness of Zataria extract mouthwash for the management of radiation-induced oral mucositis in patients: a randomized placebo-controlled double-blind study

Abstract: The use of ZM mouthwash effectively decreases the severity of oral complications induced by ionizing radiation in patients during radiotherapy and resulted in high oral quality care. Graphical abstract ᅟ.

Cited by 30 publications

References 28 publications

Comparative Study of the Effect of Licorice Root Extract Mouthwash and Combined Mouthwash on the Incidence and Severity of Chemotherapy-Induced Mucositis Symptoms in Colon Cancer Patients Admitted to Intensive Care Units

Comparative Study of the Effect of Licorice Root Extract Mouthwash and Combined Mouthwash on the Incidence and Severity of Chemotherapy-Induced Mucositis Symptoms in Colon Cancer Patients Admitted to Intensive Care Units

Anti-Inflammatory Effect of Nigella Sativa Oil on Chemoradiation-Induced Oral Mucositis in Patients With Head and Neck Cancers

Management of Oral Hygiene in Head-Neck Cancer Patients Undergoing Oncological Surgery and Radiotherapy: A Systematic Review

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