The effectivities of anti-diabetic of Chromolaena odorata L. in lowering blood sugar level: A systematic review

Abstract

Diabetes has become a significant problem that has reached an alarming level. Nowadays, almost one billion people around the world live with diabetes. In 2019, Indonesia occupied the seventh position in the world with 10,7 million people live with diabetes. Although various antihyperglycemic agents are available, diabetes is still a significant problem in the world. Siam weed (Chromolaena odorata L.) is widely used in Indonesia and traditional medicine to treat diabetes. This study aimed to determine the phytochemical content of C. odorata extract and analyze the effectiveness of the anti-diabetic of C. odorata extract in lowering blood sugar levels. The method used in this study is a systematic review with journals derived from the online databases of PubMed and Google Scholar. The journals used are journals that discuss C. odorata, extract, anti-diabetic, and blood sugar. Journal search results show, eight studies explain the potential anti-diabetic activity of C. odorata extract in lowering blood sugar levels. Data synthesis from several studies shows that C. odorata extract has potential anti-diabetic activity because it contains phytochemicals in the form of alkaloids, flavonoids, phenols, saponins, and tannins which are potent antioxidants and cytoprotectants that can lower blood sugar levels.

Penambatan Molekuler Penghambatan Aktivitas Enzim α-Amilase dan α-Glukosidase oleh Senyawa Aktif Daun Kirinyuh (Chromolaena odorata L.)

“…Daun kirinyuh (Chromolaena odorata L.) telah diidentifikasi terkandung beberapa senyawa dari golongan alkaloid, flavonoid, saponin, tanin, terpenoid, fenol, dan steroid (Hadiroseyani et al, 2007;Salsabila et al, 2021). Kelompok senyawa yang mendominan dalam ekstrak metanol daun kirinyuh ialah alkoloida, steroida dan saponin (Munte & Lubis, 2016).…”