The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Zanini, Dragana; Todorović, Nikola; Korovljev, Darinka; Štajer, Valdemar; Ostojić, Jelena; Purać, Jelena; Kojić, Danijela; Vukašinović, Elvira L.; Djordjievski, Srdjana; Sopić, Miron; Guzonjić, Azra; Ninić, Ana; Erceg, Sanja; Ostojić, Sergej M.

doi:10.1016/j.exger.2021.111574

Cited by 19 publications

(25 citation statements)

References 34 publications

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“…A total of 199 records were found through the database, including 90 unique records and 108 duplicates, while one study [ 20 ] was identified through the snowball strategy. After 81 studies with no relevance were removed through title and abstract screening, ten studies were eligible for full-text screening.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis

et al. 2023

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Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake (p = 0.01), with small to moderate effects (pooled SMD = −0.23 (from −0.40 to 0.05); pooled SMD = −0.22 (from −0.39 to 0.04); pooled SMD = −0.38 (from −0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection.

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Section: Resultsmentioning

confidence: 99%

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis

et al. 2023

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“…Unlike conventional drugs, a specific primary target has not yet been identified for H 2 , which would explain its broad efficacy in different diseases. H 2 showed great success in controlling various diseases 1 , 2 , 5 and is being evaluated for clinical applications in healthy people to improve performance and body condition 13 , 20 , 23 . However, it remains unknown how H 2 performs under healthy conditions.…”

Section: Discussionmentioning

confidence: 99%

“…H 2 protected the liver against various acute and chronic injuries in animal models by suppressing excessive oxidative stress, inflammation, and cell death 11 , 12 . In addition to liver, preventive and therapeutic effects were obtained for H 2 in various animal experiments of disease models 2 , 3 and clinical trials in humans 13 – 15 . The preventive aspect of H 2 in disease models, its antioxidant effects 7 , 8 , its function in aging 13 , 16 , among many others 17 – 19 , are paving the way for the use of H 2 in healthy people to improve body performance or as a preventive therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Adzavon

Xie

et al. 2022

Sci Rep

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Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support therapeutic functions attributed to the biological activities of H2 remain elusive. Here, using transcriptomic and metabolomic approaches coupled with biochemistry and micro-CT technics, we evaluated the effect of long-term (6 months) and daily use of H2 on liver function. Rats exposed 2 h daily to H2 either by drinking HRW (H2 dissolved in H2O) or by breathing 4% H2 gas showed reduced lipogenesis and enhanced lipolysis in the liver, which was associated with apparent loss of visceral fat and brown adipose tissue together with a reduced level of serum lipids. Both transcripts and metabolites enriched in H2-treated rats revealed alteration of amino acid metabolism pathways and activation of purine nucleotides and carbohydrate biosynthesis pathways. Analysis of the interaction network of genes and metabolites and correlation tests revealed that NADP is the central regulator of H2 induced metabolic alterations in the liver, which was further confirmed by an increase in the level of components of metabolic pathways that require NADP as substrate. Evidence of immune response regulation activity was also observed in response to exposure to H2. This work is the first to provide metabolomic and transcriptomic data to uncover molecular targets for the effect of prolonged molecular hydrogen treatment on liver metabolism.

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“…However, studies that have specifically explored the effect of H 2 on telomere maintenance are limited. Recently, a randomized controlled pilot trial showed that HRW intake for six months extended mean telomere length by ~4% [ 13 ]. More studies are still needed to determine the intervention effect of H 2 on telomere-lengthening and to identify its potential mechanism.…”

Section: Potential Mechanisms Of Molecular H 2 Act...mentioning

confidence: 99%

“…H 2 has been shown to improve lipid and glucose metabolism in patients with mild type 2 diabetes mellitus or impaired glucose tolerance [ 12 ]. Moreover, a recent study has shown that hydrogen-rich water (HRW) intake favorably affected several ageing-related features in healthy elderly, including extended mean telomere length, and tended to improve DNA methylation [ 13 ]. This review discusses the possible underlying mechanisms of H 2 acting against ageing and its potential preventive and therapeutic applications in ageing-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

Zhang

2022

Oxidative Medicine and Cellular Longevity

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Ageing is a physiological process of progressive decline in the organism function over time. It affects every organ in the body and is a significant risk for chronic diseases. Molecular hydrogen has therapeutic and preventive effects on various organs. It has antioxidative properties as it directly neutralizes hydroxyl radicals and reduces peroxynitrite level. It also activates Nrf2 and HO-1, which regulate many antioxidant enzymes and proteasomes. Through its antioxidative effect, hydrogen maintains genomic stability, mitigates cellular senescence, and takes part in histone modification, telomere maintenance, and proteostasis. In addition, hydrogen may prevent inflammation and regulate the nutrient-sensing mTOR system, autophagy, apoptosis, and mitochondria, which are all factors related to ageing. Hydrogen can also be used for prevention and treatment of various ageing-related diseases, such as neurodegenerative disorders, cardiovascular disease, pulmonary disease, diabetes, and cancer. This paper reviews the basic research and recent application of hydrogen in order to support hydrogen use in medicine for ageing prevention and ageing-related disease therapy.

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The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial

Cited by 19 publications

References 34 publications

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis

Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways

Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases

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