The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population

Stough, Con; Downey, Luke A.; Silber, Beata Y.; Lloyd, Jenny; Kure, Christina; Wesnes, Keith; Camfield, David

doi:10.1016/j.neurobiolaging.2011.03.019

Cited by 75 publications

(55 citation statements)

References 16 publications

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“…To our knowledge, the level of DHA in the brain could increase with development and decrease with aging, and it contributes to the improvement of memory and other cognitive functions among patients with Alzheimer's disease (AD) [3]. Randomized controlled trials have investigated the efficacy of n-3 FAs therapy in both impaired and non-impaired patients [4][5][6][7][8][9][10][11][12]. However, these studies have drawn inconsistent conclusions.…”

mentioning

confidence: 99%

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials

Zhang

Hou

et al. 2015

Aging Clin Exp Res

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Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly.

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mentioning

confidence: 99%

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials

Zhang

Hou

et al. 2015

Aging Clin Exp Res

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“…However, a lower dose of DHA (i.e. 252 mg/day DHA compared to 800 mg/day and 900 mg/day in Johnson et al (2008) and Yurko-Mauro et al (2010), respectively) did not influence cognitive function (Stough et al, 2012). The discrepancy in results may be due to methodological differences in the Stough and colleagues (2012) study design, including differences in DHA dose, treatment duration (limited to 90 days), or wide age range (45À77 years).…”

Section: Rcts: Healthy Older Adultsmentioning

confidence: 94%

Omega-3 Fatty Acids and Cognitive Behavior

Giles¹,

Mahoney²,

Kanarek³

2014

Omega-3 Fatty Acids in Brain and Neurological Health

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“…From the four studies in young volunteers, one was negative (Benton et al 2013), one found no effects (Jackson et al 2012), and two found at best marginal positive effects (Karr et al 2012;Stonehouse et al 2013). In elderly, two trials were positive (Lee et al 2013;Yurko-Mauro et al 2010), one where phosphatidylserine was added was marginally positive (Vakhapova et al 2010) and two found no difference (Dangour et al 2010;Stough et al 2012). Although different doses and different compositions of the relative contributions of EFA and DHA were used, there was no obvious relation with dose.…”

Section: Pufasmentioning

confidence: 97%

Declarative Memory

Riedel

Blokland

2015

Handbook of Experimental Pharmacology

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Declarative Memory consists of memory for events (episodic memory) and facts (semantic memory). Methods to test declarative memory are key in investigating effects of potential cognition-enhancing substances--medicinal drugs or nutrients. A number of cognitive performance tests assessing declarative episodic memory tapping verbal learning, logical memory, pattern recognition memory, and paired associates learning are described. These tests have been used as outcome variables in 34 studies in humans that have been described in the literature in the past 10 years. Also, the use of episodic tests in animal research is discussed also in relation to the drug effects in these tasks. The results show that nutritional supplementation of polyunsaturated fatty acids has been investigated most abundantly and, in a number of cases, but not all, show indications of positive effects on declarative memory, more so in elderly than in young subjects. Studies investigating effects of registered anti-Alzheimer drugs, cholinesterase inhibitors in mild cognitive impairment, show positive and negative effects on declarative memory. Studies mainly carried out in healthy volunteers investigating the effects of acute dopamine stimulation indicate enhanced memory consolidation as manifested specifically by better delayed recall, especially at time points long after learning and more so when drug is administered after learning and if word lists are longer. The animal studies reveal a different picture with respect to the effects of different drugs on memory performance. This suggests that at least for episodic memory tasks, the translational value is rather poor. For the human studies, detailed parameters of the compositions of word lists for declarative memory tests are discussed and it is concluded that tailored adaptations of tests to fit the hypothesis under study, rather than "off-the-shelf" use of existing tests, are recommended.

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The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population

Cited by 75 publications

References 16 publications

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials

Omega-3 Fatty Acids and Cognitive Behavior

Declarative Memory

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