This exploratory study investigated the effect of visiting therapy dogs on college-student perceived and physiological stress the week prior to final exams. Students (n = 78) were randomly assigned to order of a therapydog intervention and attention-control condition, each 15 minutes long. Students completed the Perceived Stress Scale (PSS), a stress visual analog scale (SVAS), and provided saliva for measuring nerve growth factor (sNGF) and alpha amylase (sAA), prior to randomization. Saliva samples and SVAS were again collected after each condition. There was no effect of group order on demographics, PSS, or initial SVAS. Repeated measures models were used to analyze the complete data sets of 57 students. There were no significant differences in sAA between or within students completing the intervention and control conditions. sNGF was not subjected to analysis as most levels were undetectable. Significant differences in SVAS scores were found between the intervention and control condition, with large effect sizes. SVAS scores were lower following the intervention, regardless of condition order (intervention first, p = 0.0001, d = 1.87; intervention second, p = 0.0004, d = 1.63). No SVAS differences were found for the control condition. Based on these findings, campus events with visiting therapy dogs represent a costeffective, easily accessible activity to reduce perceived, but not physiological, stress for college students prior to final exams.Keywords: animal-assisted activities, exam stress, human-animal interaction, therapy dogs Offering students the opportunity to interact with friendly dogs during exam periods is gaining popularity at colleges and universities. Tufts University, Emory University Law School, Kent State University, Harvard Medical School, and Yale Law School are among those offering such opportunities (Turner 2012;Christensen 2013). While anecdotal accounts of the popularity and benefits of these dog visits are reported, no formal studies of efficacy have been published. Before advocating for dog visits to address exam-related stress in college students, we first need evidence that such activities are effective in reducing student stress.It is well known that exams are a major stressful experience for college students. Elevated exam stress has been associated with increased tension and depression (Gilbert et al. 1996), poorer academic performance (Ng, Koh and Chia 2003), and lower student expectations of their grades (Austin, Saklofske and Mastoras 2010). Exam stress has also been negatively associated with physiological indicators of stress and immune function. Preuß and colleagues (2010) used salivary cortisol to measure physiological stress responses in college students before and after taking written and oral exams. Cortisol concentrations were elevated before, but not after, written exams and were higher before and after oral exams. Based on their findings, the authors concluded that while written exams caused a mild anticipatory stress response, oral exams elicited a strong...