The effects of a low dose of cabergoline on induction of estrus and pregnancy rates in anestrous bitches

Cirit, Ümüt; Bacınoğlu, Süleyman; Cangül, I. Taci; Kaya, Huriye Horoz; Taş, Muzaffer; Ak, Kemal

doi:10.1016/j.anireprosci.2006.09.005

Cited by 24 publications

(24 citation statements)

References 19 publications

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“…The two oral formulations which have been used are cabergoline at the dose of 5 μg kg −1 day −1 and bromocriptine at an increasing dose (up to 0.1 mg kg −1 day −1 ) until the appearance of proestrous signs. A reduced dosage of cabergoline (0.6 μg kg −1 day −1 ) was shown to be effective as well (Ajitkumar, Praseeda, Rajankutty, & Alex, ; Cirit et al., ). The duration of treatment varies from 8 to 40 days, and the efficacy of oestrous induction is highly associated with the stage of anestrus when the treatment is started (Van Haaften et al., ; Verstegen, Onclin, Silva, & Concannon, ).…”

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

“…As shown for the efficacy regarding oestrous induction, the pregnancy rate is influenced by the stage of anestrus, in which the treatment is performed with better results if treatment takes place in late anestrus. Pregnancy rates of 70% to 100% have been obtained after oestrous induction using dopamine agonists (Ajitkumar et al., ; Cirit et al., ; Gobello, Castex, & Corrada, ; Günay, Günay, & Soylu, ; Shimatsu, ; Verstegen et al., ; Zöldág, Fekete, Csáky, & Bersényi, ). In a recent study, the administration of oestradiol benzoate (unauthorized in many countries due to severe side effects), 1 week before the start of cabergoline treatment, led to significant reduction of the time span until the onset of proestrus and showed a synchronizing effect.…”

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

“…The longer the interval from the previous oestrus is, the better are the results. Therefore, the prefect candidate should be in progressed to late anestrus (vaginal cytology of anestrus and progesterone levels less than 1 ng/ml) was shown to be effective as well (Ajitkumar, Praseeda, Rajankutty, & Alex, 2010;Cirit et al, 2007). The duration of treatment varies from 8 to 40 days, and the efficacy of oestrous induction is highly associated with the stage of anestrus when the treatment is started (Van Haaften et al, 1989;Verstegen, Onclin, Silva, & Concannon, 1999).…”

Section: Oe S Trous Induc Ti On Op Ti On S Mechanis Ms Of Ac Ti Omentioning

confidence: 99%

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Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt

Santos

Fontbonne

2018

Reprod Domestic Animals

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Contents Manipulation of the oestrous cycle of the bitch is a common request of pet owners for different reasons. On one side, clients may be interested in temporally preventing oestrus until the bitch has finished the performance career, or to manage the kennel in the presence of a stud dog and to avoid undesirable breeding. Additionally, clients with no interest to use their animal for breeding, may, for ethical reasons, prefer to avoid elective surgery such as ovariectomy, to control reproduction. On the other side, clients may want to induce oestrus to better control the time of birth, to use a male with limited availability during a specific time, or to reduce the duration of the interoestrous interval in bitches with a long oestrous cycle (>8 months). Both these options for oestrous manipulation are based on hormonal treatments. For oestrous prevention, synthetic progesterone has been used since the 1960s. Induction of oestrus has been established with reliable results using dopamine agonists in the late 1980s and more recently using GnRH agonists. This review is focusing on the current and recently available treatments to manipulate the oestrous cycle in the bitch.

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Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

Section: Oe S Trous Induc Ti On Op Ti On S Mechanis Ms Of Ac Ti Omentioning

confidence: 99%

See 1 more Smart Citation

Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt

Santos

Fontbonne

2018

Reprod Domestic Animals

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“…Estrus induction in canine and feline patients has been accomplished with a variety of pharmaceutical agents. [1][2][3][4][5][6] Estrous induction is most successful in normal females; its efficacy in bitches and queens with reproductive disorders is unknown. Agents reported to be effective include synthetic estrogens (diethylstilbestrol [DES]), dopamine agonists (bromocriptine, cabergoline), GnRH agonists (lutrelin, buserelin, fertirelin, deslorelin, and leuprolide), exogenous gonadotro-pins (LH), follicle-stimulating hormone (FSH), human chorionic gonadotropin (HCG), pregnant mare serum gonadotropin (PMSG), and opiate antagonists (naloxone).…”

Section: Estrus Induction In Canine and Feline Patientsmentioning

confidence: 99%

Pharmacologic Advances in Canine and Feline Reproduction

Wiebe

Howard

2009

Topics in Companion Animal Medicine

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Substantial improvements in therapeutic options for companion animal reproduction and gynecologic emergencies have been made over the last decade. New, alternative drug treatments, with fewer side effects and improved efficacy, are available. This has widened the spectrum of therapeutic possibilities for diseases that were previously treated only by surgical intervention. New drugs are available for estrus induction and pregnancy termination, as well as for the treatment of pyometra. This review summarizes the pharmacology and toxicology of reproductive agents currently in use for contraception, pyometra, dystocia, eclampsia, premature labor, agalactia, mastitis, metritis, and prostatic disorders, and compares their efficacy and safety with newer agents. Drug use and exposure during pregnancy and lactation, and subsequent risks to the fetuses, are also explored, with emphasis on antimicrobials, antifungals, anthelminthics, anesthetics, and vaccinations.

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“…For example, hCG fails to support luteal function [13] and has no positive effects on ovulation rates in domestic dogs [14]. However, Write [15] reports that ovulation in domestic dogs is induced by hCG within 26 to 30 hours of administration.…”

Section: Introductionmentioning

confidence: 99%