The effects of acetylcholine in the heart‐lung preparation including the production of auricular fibrillation

Burn, J. H.; Williams, E. M. Vaughan; Walker, J. M.

doi:10.1113/jphysiol.1955.sp005306

Cited by 100 publications

(19 citation statements)

References 16 publications

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“…A relation between the presence of choline esters or of vagal stimulation and the likelihood of atrial ectopic rhythms have been reported by many workers (Burn, Vaughan-Williams & Walker, 1955;Nahum & Hoff, 1940;West, Tumer & Loomis, 1954). However, similar arrhythmias have not been produced in the ventricles and this is compatible with the reported insensitivity of the ventricular myocardium to acetylcholine (Hoffman & Suck-ling, 1953).…”

Section: Introductionmentioning

confidence: 75%

Studies on the effect of physostigmine on experimental cardiac arrhythmias in dogs

Das

Bhattacharya

1972

British J Pharmacology

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Summary1. Experimental cardiac arrhythmias were produced in dogs anaesthetized with pentobarbitone. Ventricular arrhythmias were induced by strophanthin-K, light petroleum plus adrenaline or coronary ligation procedures. Atrial flutter was induced by an injury-stimulation technique. The acetylcholine and glycogen concentrations of the atria and ventricles were estimated. 2. Physostigmine pretreatment (01 mg/kg) significantly reduced the incidence of ventricular arrhythmias after myocardial ischaemia but had no effect on any of the other arrhythmias. 3. Physostigmine markedly increased the acetylcholine concentrations of atria and ventricles in control dogs, to nearly the same extent. Physostigmine had no effect on ventricular acetylcholine concentrations in dogs treated with strophanthin-K and light petroleum plus adrenaline but in the coronary ligation group it caused a significant increase in the acetylcholine concentrations of both atria and ventricles, and of atrial acetylcholine only in the injury-stimulation group.4. All the arrhythmias produced marked glycogenolysis of both the atria and the ventricles, to nearly the same extent. Although physostigmine produced marked glycogenolysis in the control dogs it significantly inhibited cardiac glycogenolysis after light petroleum plus adrenaline, atrial glycogenolysis after strophanthin-K-induced arrhythmias and ventricular glycogenolysis after myocardial ischaemia.5. There appears to be a possible correlation between the increase in the acetylcholine concentration of the ventricles and anti-arrhythmic actions of physostigmine, but there is a less clear correlation between changes in the glycogen concentration of ventricles and the anti-arrhythmic action.

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Section: Introductionmentioning

confidence: 75%

Studies on the effect of physostigmine on experimental cardiac arrhythmias in dogs

Das

Bhattacharya

1972

British J Pharmacology

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“…The cholinergic mechanism has been considered to be important in the mechanism of the onset of atrial fibrillation. Burn et al (1955) applied electric stimulation of the auricle during the infusion of acetylcholine and obtained atrial fibrillation which was sustained as long as acetylcholine was continuously infused. It has been also demonstrated that the dose of acetylcholine necessary to maintain fibrillation is much smaller than the dose used for induction of fibrillation by the direct perfusion technique of the …”

Section: Discussionmentioning

confidence: 99%

“…The effects of cholinergic compounds on heart pacemaker activity have been studied by many investigators (Burn et al 1955 …”

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confidence: 99%

Effect of Tremorine and Oxotremorine on the S-A Node of the Dog Heart <i>in vivo</i>

Chiba

Igić

Nakajima

1972

Tohoku J. Exp. Med.

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“…For instance, Burn et al [29] reported the effect of ACh in the heart lung preparation including AF, and recently, Sanders et al [7] induced the AF in an isolated sheep heart. The AF effects without ladder-type ACh concentration variations were performed in the same way in these articles.…”

Section: Comparison With Experimental Studies Of Vagal Afmentioning

confidence: 99%

Investigation of Atrial Vulnerability by Analysis of the Sinus Node EG From Atrial Fibrillation Models Using a Phase Synchronization Method

Chen

Yang

et al. 2012

IEEE Trans. Biomed. Eng.

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Abstract-Atrial fibrillation (AF) can result in life-threatening arrhythmia, and a clinically convenient means for detecting vulnerability remains elusive. We investigated atrial vulnerability by analyzing the sinus electrogram (EG) from AF animal models using a phase synchronization method. Using acetylcholine (ACh)-induced acute canine AF models (n = 4), a total of 128 electrical leads were attached to the surface of the anterior and posterior atria, and the pulmonary veins to form an electrocardiological mapping system. ACh was injected at varying concentrations with ladder-type adjustments. Sinus EGs and induced AF EGs that pertain to specific ACh concentrations were recorded. We hypothesize that the atrial vulnerability may be correlated with the Shannon entropy (SE) of the phase difference matrix that is extracted from the sinus EG. Our research suggests that the combination of SE with the synchronization method enables the sinus node EG to be analyzed and used to estimate atrial vulnerability.

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The effects of acetylcholine in the heart‐lung preparation including the production of auricular fibrillation

Cited by 100 publications

References 16 publications

Studies on the effect of physostigmine on experimental cardiac arrhythmias in dogs

Studies on the effect of physostigmine on experimental cardiac arrhythmias in dogs

Effect of Tremorine and Oxotremorine on the S-A Node of the Dog Heart <i>in vivo</i>

Investigation of Atrial Vulnerability by Analysis of the Sinus Node EG From Atrial Fibrillation Models Using a Phase Synchronization Method

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