The effects of acute and chronic lithium treatment on rat submandibular salivation

Popović, Jelena; Krsljak, Elena; Grbović, Leposava; Stojić, Dragica Lj.

doi:10.1111/j.1601-0825.2004.01066.x

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…In the second experiment, the rats were intraperitoneally injected with 45 mg/kg body weight (7.30 mg Li + /kg b.w.) also in the morning (between 8:00-9:00 a.m.) The dose of 7.30 mg/kg is representative of the therapeutic range in humans [5].…”

Section: Experiments Injecting Liclmentioning

confidence: 99%

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Lithium Induces Glycogen Accumulation in Salivary Glands of the Rat

Souza

Mendes

Nogueira

et al. 2015

Biol Trace Elem Res

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Lithium is administered for the treatment of mood and bipolar disorder. The aim of this study was to verify whether treatment with different concentrations of lithium may affect the glycogen metabolism in the salivary glands of the rats when compared with the liver. Mobilization of glycogen in salivary glands is important for the process of secretion. Two sets of experiments were carried out, that is, in the first, the rats received drinking water supplemented with LiCl (38,25 and 12 mM of LiCl for 15 days) and the second experiment was carried out by intraperitoneal injection of LiCl solution (12 mg/kg and 45 mg LiCl/kg body weight) for 3 days. The active form of glycogen phosphorylase was not affected by treatment with LiCl considering the two experiments. The active form of glycogen synthase presented higher activity in the submandibular glands of rats treated with 25 and 38 mM LiCl and in the liver, with 25 mM LiCl. Glycogen level was higher than that of control in the submandibular glands of rats receiving 38 and 12 mM LiCl, in the parotid of rats receiving 25 and 38 mM, and in the liver of rats receiving 12 mM LiCl. The absolute value of glycogen for the submandibular treated with 25 mM LiCl, and the liver treated with 38 mM LiCl, was higher than the control value, although not statistically significant for these tissues. No statistically significant difference was found in the submandibular and parotid salivary glands for protein concentration when comparing experimental and control groups. We concluded that LiCl administered to rats influences the metabolism of glycogen in salivary glands.

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Section: Experiments Injecting Liclmentioning

confidence: 99%

“…Treatment with this psychoactive monovalent cation is commonly accompanied by alteration in salivary secretion leading to hyposalivation [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%