The Effects of Acute and Chronic Exercise on Paraoxonase-1 (PON1): A Systematic Review With Meta-Analysis

Taylor, J. Kyle; Carpio-Rivera, Elizabeth; Chacón-Araya, Yamileth; Grandjean, Peter W.; Moncada-Jiménez, José

doi:10.1080/02701367.2020.1812493

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…However, this enzyme is also affected by weight gain and a sedentary lifestyle (42). However, exercise increases its level (43). Nonetheless, we could not reach any definite results about the effect of RT on it.…”

Section: Discussionmentioning

confidence: 71%

The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men

Baghaiee

Farahani

Pescatello

et al. 2022

J Shahrekord Univ Med Sci

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Background and aims: Primary hypertension, an unexplained increase in blood pressure (BP), accounts for 90% of the cases of hypertension and remains a critical public health challenge. This study aimed to investigate the effects of 12-week resistance training (RT) on some vasodilators and vasoconstrictors in hypertensive men. Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12. Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Adiponectin, apelin, atrial natriuretic peptide (ANP), and paraoxonase-1 (PON-1) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01), while endothelin-1 (ET-1) and H2 O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group. Conclusion: Overall, 12-week RT led to an increase in apelin, ANP, PON-1, and adiponectin. Increasing these markers reduces H2 O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.

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Section: Discussionmentioning

confidence: 71%

The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men

Baghaiee

Farahani

Pescatello

et al. 2022

J Shahrekord Univ Med Sci

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Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function

Beazer,

Sillars,

Beck

et al. 2024

Bioscience Reports

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Given the failure of high-density lipoprotein (HDL) raising therapies to reduce cardiovascular disease risk, attention has turned towards HDL composition and vascular protective functions. In individuals with insulin resistance, exercise interventions recover HDL function. However, the effect of exercise on HDL in otherwise healthy individuals is unknown. This cross-sectional study aimed to measure HDL composition and antioxidant / endothelial anti-inflammatory function in insulin sensitive endurance athlete and healthy control men. HDL was isolated using density gradient ultracentrifugation. HDL composition was measured using microplate assays for apolipoprotein A-I, total cholesterol content and apolipoprotein M. HDL protein composition was measured using nano-liquid chromatography tandem mass spectrometry. HDL subclass distribution was measured by native gel electrophoresis. HDL in vitro antioxidant function was measured by paraoxonase-1 activity assay and anti-inflammatory function assessed in endothelial cells. Compared to controls, endurance athlete HDL had higher apolipoprotein A-1 (1.65 ± 0.62 mg/mL vs 1.21 ± 0.34 mg/mL, p = 0.028) and higher total cholesterol content (1.54 ± 0.33 mmol/L vs 2.09 ± 0.44 mmol/L, p < 0.001). Proteomics revealed higher apolipoprotein A-II, A-IV and D and transthyretin in endurance athlete HDL versus controls. There was no difference observed in in vitro HDL antioxidant or anti-inflammatory functions between controls and endurance athletes. Despite a more favourable composition, endurance athlete HDL did not have higher in vitro antioxidant or anti-inflammatory function. It is possible that HDL has a ceiling of function, i.e. that healthy HDL function cannot be enhanced by endurance exercise.

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The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome

Diba Hosaini,

Vafaee,

Abedi

2022

Hormozgan medical journal

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Background: Irisin is a myokine suggested to exert anti-obesity benefits. On the other hand, paraxonase-1 (PON 1) is one of the most important free radical scavenging enzymes and is among the main protectors of lipoproteins against oxidizing compounds. This study aimed to evaluate the effect of 8 weeks of concurrent training on serum levels of irisin, PON 1, lipid profile, and insulin resistance in men with metabolic syndrome. Methods: In this quasi-experimental study, 30 men with metabolic syndrome (aged 25-35 years and with body mass>25 kg.m-2) were purposefully selected and randomly divided into two groups of concurrent training (n=15) and control (n=15). Three sessions of the training program were held per week over an 8-week interval. Concurrent training included warm-up, resistance (20 minutes of resistance training), and endurance (25 minutes of activity on a stationary bike with an intensity of 50%-80% of maximum heart rate). Blood samples were collected before and 24 hours after exercise to measure serum levels of variables. Data were analyzed using independent and dependent t-tests. Results: At baseline, serum levels of PON 1, irisin, and high-density lipoprotein (HDL) were higher in the concurrent training group. The results of the study also indicated that 8 weeks of concurrent training significantly reduced the levels of insulin resistance, triglycerides (TG), cholesterol, low-density lipoprotein (LDL), systolic, and diastolic blood pressure in men with metabolic syndrome. Conclusion: Eight weeks of concurrent training improves the levels of irisin, insulin resistance, PON 1, and lipid profile of men with metabolic syndrome.

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The Effects of Acute and Chronic Exercise on Paraoxonase-1 (PON1): A Systematic Review With Meta-Analysis

Cited by 3 publications

References 64 publications

The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men

The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men

Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function

The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome

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