The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients

Quinten, Chantal; Coens, Corneel; Ghislain, Irina; Zikos, Efstathios; Sprangers, Mirjam A. G.; Ringash, Jolie; Martinelli, Francesca; Ediebah, Divine E.; Maringwa, John; Reeve, Bryce B.; Greimel, Eva; King, Madeleine; Bjordal, Kristin; Flechtner, H.; Koch, J. Schmucker-Von; Taphoorn, Martin J.B.; Weis, Joachim; Wildiers, Hans; Velikova, Galina; Bottomley, Andrew

doi:10.1016/j.ejca.2015.08.027

Cited by 122 publications

(95 citation statements)

References 39 publications

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“…Furthermore, they scored significantly better than the elderly on interest in sex. 21 A likely explanation for the differences in HR-QOL between younger and older survivors is the fact that, in the natural course of aging, a decline in functional status, and, thus, physical HR-QOL occurs. 10 That study found that adolescents and young adult thyroid cancer survivors (17-39 years) reported significantly less neuromuscular, voice, sympathetic, and throat/mouth complaints than older (40 years) survivors.…”

Section: Discussionmentioning

confidence: 99%

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

et al. 2018

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“…For example, patients with similar disease states but with different demographics (eg, age, gender, socioeconomic status etc.) may report different scores when assessed with HRQoL tools . Aside from demographics, cultural background also impacts patients’ experience of their disease and treatment and thus will affect the scores reported via HRQoL tools .…”

Section: Patients’ Experience With Hcv Infectionmentioning

confidence: 99%

The impact of hepatitis C virus outside the liver: Evidence from Asia

Younossi

Tanaka

Eguchi

et al. 2016

Liver International

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Between 80 and 115 million people worldwide are chronically infected with hepatitis C virus, with 60%-90% of these being undiagnosed. Untreated chronic hepatitis C (CHC) is associated with progressive liver disease, cirrhosis, hepatocellular carcinoma and liver-related mortality. A number of extrahepatic manifestations are also reported in CHC patients, further adding to the burden of the disease. CHC also impacts patients in terms of lower health-related quality of life, higher levels of fatigue and reduced productivity. Furthermore, the later stages of disease are costly for both healthcare systems and society. Pegylated-interferon (PEG-IFN)+ribavirin (RBV), for many years the mainstay of treatment, leads to sustained virological response (SVR) in 40%-70% of patients. However, a substantial number of patients are ineligible for treatment, and many patients fail to achieve SVR with this regimen. Furthermore, PEG-IFN+RBV leads to impairment of patient-reported outcomes during treatment, and most patients suffer from adverse events, associated with poor adherence, treatment discontinuation and treatment failure. The approval of second-generation directacting antivirals (DAAs) has revolutionized the treatment of CHC patients. All-oral, PEG-IFN and RBV-free regimens have higher efficacy rates, shorter treatment durations, fewer adverse events, higher adherence rates and improvement in PROs from as early as Week 4, compared to PEG-IFN+RBV regimens. The aim of this article is to review the evidence for HCV infection as a systemic disease, summarizing the impact of hepatitis C and its treatments on clinical, patient and economic outcomes, with a focus on data from Asia and Japan specifically. K E Y W O R D Scost-effectiveness, hepatitis C, health-related quality of life, patient-reported outcomes, work productivity

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“…3 Patient reported outcome measures (PROM) are an established component of cancer outcomes reporting. 6 In a critical review, Aggarwal et al summarized global radiation therapy research between 2001 and 2015, and reported increasing numbers of HRQOL papers from a range of different countries. Health-related quality of life (HRQOL) assessment is embedded in many clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Variations in concerns reported on the patient concerns inventory in patients with head and neck cancer from different health settings across the world

et al. 2019

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Background:The aim was to collate and contrast patient concerns from a range of different head and neck cancer follow-up clinics around the world.Also, we sought to explore the relationship, if any, between responses to the patient concerns inventory (PCI) and overall quality of life (QOL). Methods: Nineteen units participated with intention of including 100 patients per site as close to a consecutive series as possible in order to minimize selection bias.Results: There were 2136 patients with a median total number of PCI items selected of 5 (2-10). "Fear of the cancer returning" (39%) and "dry mouth" (37%) were most common. Twenty-five percent (524) reported less than good QOL.Conclusion: There was considerable variation between units in the number of items selected and in overall QOL, even after allowing for case-mix variables.There was a strong progressive association between the number of PCI items and QOL. K E Y W O R D Shead and neck cancer, patient concerns inventory, patient prompt list, quality of life

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The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients

Abstract: Background

Cited by 122 publications

References 39 publications

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

Age‐related differences in health‐related quality of life among thyroid cancer survivors compared with a normative sample: Results from the PROFILES Registry

The impact of hepatitis C virus outside the liver: Evidence from Asia

Variations in concerns reported on the patient concerns inventory in patients with head and neck cancer from different health settings across the world

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