1961
DOI: 10.1172/jci104332
|View full text |Cite
|
Sign up to set email alerts
|

The Effects of Aging and Degenerative Vascular Disease on the Measurement of Arterial Rigidity in Man*

Abstract: In 1937, Hallock and Benson demonstrated a progressive loss of aortic distensibility with aging (1). Their observations on the pressure-volume relationship in segments of human aortas from five age groups are shown in Figure 1. The curves which represent the less distensible older aortas have a greater slope (d P/d V). The slope of each curve is not fixed, however, and it changes by bending toward the pressure axis as pressure increases. The rate of this change in slope (or the curvature) also is greater in th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
12
0

Year Published

1961
1961
2008
2008

Publication Types

Select...
3
3
1

Relationship

1
6

Authors

Journals

citations
Cited by 48 publications
(15 citation statements)
references
References 8 publications
3
12
0
Order By: Relevance
“…Previous findings and interpretation of the systolic-ondiastolic slope About half a century ago, Conway and Smith [24,25] and Abboud and Huston [26,27] attempted to characterize the tendency of arteries to stiffen upon elevating pressure using intra-arterial BP changes that occur immediately after inhalation of amyl nitrite but before the onset of reflex tachycardia. The 'arterial rigidity index' was defined as the ratio of the change in pulse pressure to the related decrease in diastolic pressure during this period [24][25][26][27].…”
Section: Potential Clinical Impact Of the Methods Of Slope Determinationmentioning
confidence: 99%
See 1 more Smart Citation
“…Previous findings and interpretation of the systolic-ondiastolic slope About half a century ago, Conway and Smith [24,25] and Abboud and Huston [26,27] attempted to characterize the tendency of arteries to stiffen upon elevating pressure using intra-arterial BP changes that occur immediately after inhalation of amyl nitrite but before the onset of reflex tachycardia. The 'arterial rigidity index' was defined as the ratio of the change in pulse pressure to the related decrease in diastolic pressure during this period [24][25][26][27].…”
Section: Potential Clinical Impact Of the Methods Of Slope Determinationmentioning
confidence: 99%
“…The 'arterial rigidity index' was defined as the ratio of the change in pulse pressure to the related decrease in diastolic pressure during this period [24][25][26][27]. This parameter, which resembles to some extent the systolic-on-diastolic slope, increased steeply with age and for hypertensive patients with arteriosclerosis.…”
Section: Potential Clinical Impact Of the Methods Of Slope Determinationmentioning
confidence: 99%
“…The ratio of the change in pulse pressure X 100 to the related decrease in diastolic pressure during this period is the index of arterial rigidity (Figure 1). A detailed protocol of the test procedure has been presented (3). A complete physical examination and a careful review of the clinical record followed the performance of the test in each patient.…”
Section: Methodsmentioning
confidence: 99%
“…Our findings do not support this hypothesis, since the majority of patients in this study had normal rigidity indices for their age. (3) in which the effect of age on the rigidity index was determined. These "normal" subjects were selected to satisfy certain criteria among which were the absence of a family history of diabetes, of grade III or IV retinopathy and of left ventricular hypertrophy.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation