The effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches

Kaya, Doǧan; Küçükaslan, İbrahim; Ağaoğlu, Ali Reha; Ay, Serhan Serhat; Schäfer-Somi, Sabine; Emre, Birten; Bal, Yelda; Einspanier, A.; Gürcan, İsmayil Safa; Gültiken, Nilgün; Aslan, Selim

doi:10.1016/j.anireprosci.2014.03.002

Cited by 13 publications

(19 citation statements)

References 35 publications

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“…15 No other protocol tried previously had a more meaningful improvement than single AGL use in this pregnancy period of dogs. 10,11,20 In the present study, no significant difference was found in the T-SA and the T-EA between groups. These parameters were in parallel with previous studies that reported vaginal discharge starting in 4-7 days, 13 and fetal expulsion occurring in 5-9 days, 13 in 8 days 12 and in an average of 4.4 days after the first AGL injection.…”

Section: Clinical Findingscontrasting

confidence: 69%

“…7 Aglepristone has been reported to be safe and effective in inducing abortions, in preventing pregnancy and in inducing labour in bitches and cats. 5,[8][9][10][11][12][13][14] However, the success rate of AGL decreases as the gestation period progresses. 15 The cost, lack of licensing and limited availability are the main disadvantages of AGL.…”

Section: Effect Of Oral Misoprostol Alone or In Combination With Aglmentioning

confidence: 99%

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Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Aslan

Önyay

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives This study aimed to determine the efficacy and safety of oral misoprostol (MIS) administration in the induction of mid-term pregnancy termination in cats. Methods Twenty-eight cats that were pregnant for 30-40 days were allocated to four groups. The aglepristone (AGL) group (n = 7) received 10 mg/kg SC aglepristone q24h for two consecutive days. In the AGL+MIS group (n = 7), AGL (as administered in the AGL group) and MIS (200 µg/cat PO q12h until the start of abortion) were administered. The MIS200 (n = 7) and MIS400 groups (n = 7) received MIS (200 or 400 µg/cat misoprostol, respectively) alone PO q12h until the start of abortion. Blood samples were collected at the start of treatment (d0), 4 days after the start of treatment (d4) and on the day of complete abortion/end of administration (dA/d7). Results The efficacy of the treatment was 71.4% in the AGL group, 100% in the AGL+MIS group, 0% in MIS200 group and 57.4% in MIS400 group ( P = 0.004). No significance was found in relation to the interval from treatment to the start/end of abortion and the duration of abortion in all groups. The most observed side effect was vomiting in both groups administered MIS, particularly in the MIS400 group (56.7%). Progesterone (P4) concentrations were reduced during the abortion, but not to basal levels, in all groups. P4 concentrations were significantly lower at dA/d7 in the MIS400 group compared with the AGL and AGL+MIS groups ( P = 0.002). Conclusions and relevance The results obtained from this study showed that low doses of MIS do not induce abortions in cats but increase the effect of AGL. Although higher doses could terminate pregnancies, this also causes intense unwanted side effects. Therefore, the use of MIS alone as an abortifacient in cats is not recommended. For mid-term pregnancy termination in cats, the combination of misoprostol and aglepristone provides a more effective abortifacient than using either of them alone.

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Section: Clinical Findingscontrasting

confidence: 69%

Section: Effect Of Oral Misoprostol Alone or In Combination With Aglmentioning

confidence: 99%

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Aslan

Önyay

et al. 2018

Journal of Feline Medicine and Surgery

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“…The prolonged inhibitory effect on progesterone receptors [14] is exerted not only at uterine level, where it lowers the relapse rate, but also at the central level [31], where it shortens the inter-estrus period [7]; moreover, aglepristone binds with hypothalamic receptors for progesterone, probably counteracting the negative feedback exerted by gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone on progesterone release and allowing an earlier follicular maturation [14]. While aglepristone competitively act on progesterone receptors, prostaglandins have a luteolytic effect [12], directly decreasing the blood progesterone concentration [32]. The synergistic actions of these 2 molecules contributed to the high success rate achieved.…”

Section: Discussionmentioning

confidence: 99%

Fertility outcome after medically treated pyometra in dogs

Melandri

Veronesi

Pisu³

et al. 2019

J Vet Sci

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Cystic endometrial hyperplasia-pyometra complex (CEH/P) is a challenge in canine reproduction. Present study aimed to assess fertility after medical treatment. One-hundred-seventy-four bitches affected by CEH/P received aglepristone on days 1, 2, 8, then every 7 days until blood progesterone < 1.2 ng/mL; cloprostenol was administered on days 3 to 5. Records were grouped according to bodyweight (BW): small (< 10 kg, n = 33), medium (10 ≥ BW < 25 kg, n = 44), large (25 ≥ BW < 40 kg, n = 52), and giant bitches (BW ≥ 40 kg, n = 45). Age; success rate; aglepristone treatments number; relapse, pregnancy rates; diagnosis-relapse, -first, -last litter intervals; litters number after treatment, and LS were analyzed by ANOVA. Overall age was 5.14 ± 1.75 years, without difference among groups. Treatment was 100% successful, without difference in treatments number (4.75 ± 1.18), relapse (15/174, 8.62%) and pregnancy (129/140 litters, 92.14%) rates, intervals diagnosis-relapse (409.63 ± 254.9 days) or -last litter (418.62 ± 129.03 days). The interval diagnosis-first litter was significantly shorter (163.52 ± 51.47 days) and longer (225.17 ± 90.97 days) in small and giant bitches, respectively. Overall, 1.47 ± 0.65 litters were born after treatment. Expected LS was achieved in each group, as shown by ΔLS (actual-expected LS by breed, overall −0.40 ± 1.62) without differences among groups. Concluding, CEH/P affects younger dogs than previously described. Relapses were rarer than previously reported. Medical treatment with aglepristone+cloprostenol is effective and safe, preserving subsequent fertility, as demonstrated by negligible changes in LS.

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“…While AGL has genotoxic and cytotoxic effects on bone marrow when used to terminate mid-term pregnancies in rabbits [30] , there is no evidence of such side effects in cats or dogs; both AGL and CBG have been reported to be safe in dogs and cats aside from some mild side effects (diarrhea, anorexia/depression, inflammation at injection site, lethargy for AGL) [13,14,20] and (vomiting for CBG) [1] . The side effects from combined use were related to PGF 2 α [11] .…”

Section: Discussionmentioning

confidence: 99%

“…Combined hormone treatments for termination of pregnancy such as AGL+PGE1 [19] , AGL+PGF 2 α [20] , or CBG+PGF 2 α [8] have been used with satisfying results in dogs. Although reports of combined hormone treatments in cats are not as prevalent as in dogs, a few studies use combined treatments to terminate the pregnancy in cats.…”

Section: Introductionmentioning

confidence: 99%

Kedilerde Orta Dönem Gebeliklerin Sonlandırılmasında Aglepriston ve Cabergolinin Tek Başlarına veya Birlikte Uygulanmasının Etkinliği

Ay¹,

Önyay²,

Saral³

et al. 2018

Kafkas Univ Vet Fak Derg

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This study determined the efficacy of a combination of aglepristone and cabergoline on termination of mid-term cat pregnancies. Twenty cats with unwanted pregnancies between 30-40 days were included in the study. Aglepristone (10 mg/kg, sc) was given to the AGL group (n=6) twice in a 24-h interval. Cabergoline (5 μg/kg, peros) was administered to the CBG group (n=7) once daily until abortion started or for 8 days. AGL+CBG (n=7) received a combined treatment with both drugs. Abortion occurred in 50% of cats in the AGL group, 71.4% in the CBG group, and 100% in the AGL+CBG. However, the completion of pregnancy termination rate was 85.7% because of fetal retention in one cat from the AGL+CBG group. The interval between treatment-start of abortion (T-SA) was shorter in the AGL+CBG group (3.6±0.3 days) than in the AGL (6.5±0.0) and CBG (6.2±0.2) groups (P<0.01). Similarly, the interval between treatment-end of abortion (T-EA) was shorter in the combined group (4.3±0.5 days) than the others (7.3±0.3 and 6.9±0.9 days, respectively) (P<0.01). Decreasing in progesterone concentration was non-significant in the AGL group from the start of treatment to abortion completion day (dA/d8), but significant in the others (P<0.001). On dA/d8, it was significantly lower in the CBG group (P<0.01) and combined group (P<0.01) than in the AGL group. Only slight diarrhea was observed in 15.4% of the AGL+CBG group. In conclusion, the AGL+CBG combination increased the rate of abortion induction and significantly shortened T-SA and TEA with negligible side effects.

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The effects of aglepristone alone and in combination with cloprostenol on hormonal values during termination of mid-term pregnancy in bitches

Cited by 13 publications

References 35 publications

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

Fertility outcome after medically treated pyometra in dogs

Kedilerde Orta Dönem Gebeliklerin Sonlandırılmasında Aglepriston ve Cabergolinin Tek Başlarına veya Birlikte Uygulanmasının Etkinliği

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