The Effects of Alpha‐Methyl‐3, 4‐Dihydroxy‐L‐Phenylalanine (Methyldopa, Aldomet) on Erythrocytes

Wurzel, Harold A.; Silverman, Jackie

doi:10.1111/j.1537-2995.1968.tb02400.x

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…Cephalothin has been noted to alter the red cell surface so that normal IgG and other plasma proteins are adsorbed in a non-immunological manner producing a positive antiglobulin test [15]. Wurzel and Silverman reported a similar phenomenon when methyldopa was incubated in vitro with normal red cells [24]. This in itself would not explain the development of the Rh specific erythrocyte antibodies we and others have observed in the sera and eluates of these patients [14].…”

Section: Discussionmentioning

confidence: 76%

Serologic Abnormalities Associated with L-Dopa Therapy

Henry¹,

Goldberg²,

Sturgeon³

et al. 1971

Vox Sanguinis

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Eighty patients with Parkinson’s disease participating in a drug trial of L-dopa were studied prospectively for the development of antierythrocyte, antinuclear, and antiglobulin activities. The median age of the group was 65 years; and the median dose of L-dopa was 4 g/day. Five of the 80 patients developed positive red cell antiglobulin tests after 8 to 11 months of therapy. Three of these had IgG only on their red cells ; eluates prepared from these cells reacted strongly with all except Rhnun erythrocytes, suggesting Rh specificity. Complement only was detected on the cells of the other 2 patients. One of the 5 individuals with positive erythrocyte antiglobulin tests became anemic. Significant titers of antinuclear antibody appeared in 9 patients and significant increases in titers of serum antiglobulins were found in 9 patients, 2 of whom also had a positive ANA test. These results indicate that administration of L-dopa is associated with induction of a variety of autoantibodies. The mechanism responsible for this phenomenon is unknown.

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Section: Discussionmentioning

confidence: 76%

Serologic Abnormalities Associated with L-Dopa Therapy

Henry¹,

Goldberg²,

Sturgeon³

et al. 1971

Vox Sanguinis

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show abstract

“…Cephalothin has been noted to alter the red cell surface so that normal IgG and other plasma proteins are adsorbed in a non-immunological manner producing a positive antiglobulin test [15]. WURZEL and SILVERMAN reported a similar phenomenon when methyldopa was incubated i n vitro with normal red cells [24]. This in itself would not explain the development of the Rh specific erythrocyte antibodies we and others have observed in the sera and eluates of these patients [14].…”

Section: Discussionmentioning

confidence: 96%

Serologic Abnormalities Associated with L‐Dopa Therapy¹

et al. 1971

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Abstract. Eighty patients with Parkinson's disease participating in a drug trial of L‐dopa were studied prospectively for the development of antierythrocyte, antinuclear, and antiglobulin activities. The median age of the group was 65 years; and the median dose of L‐dopa was 4 g/day. Five of the 80 patients developed positive red cell antiglobulin tests after 8 to 11 months of therapy. Three of these had IgG only on their red cells; eluates prepared from these cells reacted strongly with all except Rhnull erythrocytes, suggesting Rh specificity. Complement only was detected on the cells of the other 2 patients. One of the 5 individuals with positive erythrocyte antiglobulin tests became anemic. Significant titers of antinuclear antibody appeared in 9 patients and significant increases in titers of serum antiglobulins were found in 9 patients, 2 of whom also had a positive ANA test. These results indicate that administration of L‐dopa is associated with induction of a variety of autoantibodies. The mechanism responsible for this phenomenon is unknown.

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“…The mechanism of such heterospecific immune response in the rabbits is still unclear. Since AMD, some of its metabolites and other related catecholamines are known to induce positive direct antiglobulin reactions irz vitro (Wurzel and Silverman, 1968) and methyldopa polymer selectivity binds yG (Sassetti et d., 1969)~ it is not improbable that such passive binding may cause a positive direct antiglobulin reaction in a large proportion of patients on Aldomet therapy. It has been shown by Grob, Frommel, Islikes and Masouredis (1967) that lionspecifically altered y G adheres to erythrocytes in larger amounts than native y G which is normally bound in insignificaiit amounts.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenetic mechanism for this unique high incidence reaction to AMD is unknown and immunological cross-reaction appeared to be most likely. Wurzel and Silverman (1968) have reviewed several published case reports along with their series of patients on AMD therapy. They also observed that AMD, some of its metabolites and related catecholamines could produce a positive direct antiglobulin test when they are incubated with anticoagulated normal blood.…”

mentioning

confidence: 99%

Experimental Study of Aldomet‐Induced Positive Antiglobulin Reaction. I

Vyas¹,

Sassetti²,

Petz³

et al. 1969

Br J Haematol

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Summary: Methyldopa polymer binds to red cells. Autologous red cells coated with polymer and polymer mixed with complete Freund's adjuvant induced heterospecific immune responses in rabbits resulting in the production of antibodies against human γ‐globulin and other plasma proteins. Therefore methyldopa polymer possibly is a heterospecific hapten. The γG bound to red cells of patients on methyldopa therapy differs from native γG and shows immunologic cross‐reactivity with rabbit γG. Two possible mechanisms for producing positive antiglobulin reaction in a large number of patients (10–20 per cent) on methyldopa and infrequent haemolytic anaemia in such patients are discussed.

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The Effects of Alpha‐Methyl‐3, 4‐Dihydroxy‐L‐Phenylalanine (Methyldopa, Aldomet) on Erythrocytes

Cited by 14 publications

References 11 publications

Serologic Abnormalities Associated with L-Dopa Therapy

Serologic Abnormalities Associated with L-Dopa Therapy

Serologic Abnormalities Associated with L‐Dopa Therapy¹

Experimental Study of Aldomet‐Induced Positive Antiglobulin Reaction. I

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The Effects of Alpha‐Methyl‐3, 4‐Dihydroxy‐L‐Phenylalanine (Methyldopa, Aldomet) on Erythrocytes

Cited by 14 publications

References 11 publications

Serologic Abnormalities Associated with L-Dopa Therapy

Serologic Abnormalities Associated with L-Dopa Therapy

Serologic Abnormalities Associated with L‐Dopa Therapy1

Experimental Study of Aldomet‐Induced Positive Antiglobulin Reaction. I

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Serologic Abnormalities Associated with L‐Dopa Therapy¹