The Effects of an Arabinogalactan-Protein from the White-Skinned Sweet Potato (<i>Ipomoea batatas</i> L.) on Blood Glucose in Spontaneous Diabetic Mice

Oki, Naoko; Nonaka, Seiko; Ozaki, Sei

doi:10.1271/bbb.100711

Cited by 21 publications

(15 citation statements)

References 9 publications

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“…According to Oki et al (24), arabinogalactan isolated from the tuberous cortex of WSSP is an antidiabetic compound that can decrease the elevation in plasma glucose levels by reducing insulin resistance. The active component isolated from WSSP has a high molecular weight (24). In addition, resistant starch may be a promising dietary fiber for the preventing or managing diabetes and the related diseases.…”

Section: Discussionmentioning

confidence: 99%

“…White sweet potato (WSP; Ipomoea batatas L.) belongs to the Convolvulaceae family. WSP extracts have antidiabetic activity in both insulin-deficient and -resistant diabetic models (21)(22)(23)(24)(25). In patients with T2DM, WSP tuber extract effectively reduced insulin resistance as well as fibrinogen, fasting plasma glucose, and low-density lipoprotein-cholesterol levels (26)(27)(28).…”

mentioning

confidence: 99%

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White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Shih

Chen

Varga

et al. 2020

Food & Nutrition Research

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Shih

Chen

Varga

et al. 2020

Food & Nutrition Research

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“…Available epidemiological evidence showed that the negative association between the Hedonic pattern and insulin resistance could be attributable to the pattern's healthy components, which may include alcohol in a moderate amount ( 31 , 32 ) , fresh vegetables ( 2 ) , tubers ( 33 ) and some micronutrients such as vitamin C ( 34 ) , Mg ( 35 , 36 ) , Zn ( 37 ) and Se ( 38 ) . Contribution of these components was supported by the present results.…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns are associated with insulin resistance in Chinese adults without known diabetes

et al. 2012

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The aim of the present study was to examine the association between dietary patterns and insulin resistance in Chinese adults without known diabetes. Study subjects were 1070 Chinese adults aged 18 years and above in Jiangsu Province who participated in the 2006 wave of the China Health and Nutrition Survey. Usual dietary intake was assessed by using a validated FFQ. Dietary patterns were identified by factor analysis using a principal component analysis method. Insulin resistance was defined as the highest quartile of the homeostasis model assessment of insulin resistance (HOMA-IR) scores. We derived four dietary patterns in our population by factor analysis: the Western, High-wheat, Traditional and Hedonic pattern. After adjusted for potential confounders, the Western pattern was significantly associated with greater odds for insulin resistance (P for trend¼ 0·009), while a significant negative association was found between the Hedonic pattern and insulin resistance (P for trend¼ 0·035). Compared with the lowest quartile of the Western pattern, the highest quartile had higher odds of insulin resistance (adjusted OR 1·89, 95 % CI 1·12, 3·19). There was a 42 % decrease in the odds after adjustment for all covariates in the highest quartile of the Hedonic pattern, compared with the lowest quartile (adjusted OR 0·58, 95 % CI 0·34, 0·99). HOMA-IR levels as a continuous variable also increased across the quartiles of the Western pattern and decreased across the quartiles of the Hedonic pattern. In conclusion, dietary patterns were significantly associated with insulin resistance in Chinese adults without known diabetes.

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“…The average molecular weight of SPG-1 was 508.3 kD. 9 This difference may be attributed to the fact that both lectin and arabinogalactan protein are only portions of glycoprotein. Nevertheless, the fact that potato lectin is only a portion of glycoproteins and the yield from this study was based on a dry basis should be noted.…”

Section: Resultsmentioning

confidence: 98%

“…Ozaki et al 8 and Oki et al 9 found that an arabinogalactan protein (WSSP-AGP) from the white-skinned sweet potato has hypoglycemic effects. In our previous study, 2 we found that SPG exhibits a dose-dependent hypolipidemic effect.…”

Section: Introductionmentioning

confidence: 99%

Immune activity of sweet potato (Ipomoea batatas L.) glycoprotein after enzymatic and chemical modifications

Xia

Zheng

et al. 2015

Food Funct.

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This study aimed to investigate the immune activity of sweet potato (Ipomoea batatas L.) glycoprotein (SPG-1) before and after enzymatic and chemical modifications. The protein portion of SPG-1 was modified by pepsin, trypsin, and acetylation treatments. The carbohydrate portion was modified by glucoamylase, NaIO4, and sulfation treatments. The carbohydrate chain of SPG-1 (SPG-1-C) was obtained. Immune activity was analyzed by measuring the serum lysozyme activity and T cell immune response. SPG-1 increased immune activity with a dose-response effect. Immune activity was slightly decreased after pepsin and trypsin hydrolysis, whereas it increased after a moderate degree (DS = 0.68) of acetylation. Immune activity was partly decreased after glucoamylase hydrolysis, remarkably decreased after NaIO4 oxidation, or was lost after a high modification by sulfation. Compared with SPG-1 groups, the SPG-1-C groups increased immune activities had insignificant (P > 0.05) differences. Hence, appropriate modifications of the protein portion could be conducted and it was found that high modifications of the carbohydrate portion should be avoided to improve or maintain the immune function of SPG-1.

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The Effects of an Arabinogalactan-Protein from the White-Skinned Sweet Potato (Ipomoea batatas L.) on Blood Glucose in Spontaneous Diabetic Mice

Cited by 21 publications

References 9 publications

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Dietary patterns are associated with insulin resistance in Chinese adults without known diabetes

Immune activity of sweet potato (Ipomoea batatas L.) glycoprotein after enzymatic and chemical modifications

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