The Effects of an Artificial Meniscus Substitute in a Knee Joint With a Resected Anterior Cruciate Ligament

Sommerlath, Karola; Gillquist, Jan

doi:10.1097/00003086-199304000-00041

Cited by 20 publications

(23 citation statements)

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“…Inflammatory changes associated with the ACLT model include joint effusions and synovial membrane hyperplasia, 29 which represent an important mechanism of joint pain in patients with OA. 30 31 In the present study we observed antiinflammatory activities of intra-articular GlcNAc with a reduction in the severity of synovitis.…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Shikhman

2005

Annals of the Rheumatic Diseases

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Objective: To examine the therapeutic efficacy of N-acetylglucosamine (GlcNAc) in rabbits with experimental osteoarthritis (OA). Methods: Experimental OA was induced in rabbits by anterior cruciate ligament transection (ACLT). In the first study, rabbits (six in each group) received intramuscular injections of GlcNAc or normal saline three times a week starting 1 week postoperatively. In the second study, rabbits (eight in each group) were injected intra-articularly with GlcNAc (either once or twice a week) or normal saline. In the third study, rabbits (seven in each group) were injected intra-articularly twice a week with either GlcNAc, hyaluronan, or normal saline. Animals were killed 8 weeks after ACLT for macroscopic and histological assessment of the knee joints. Results: Intramuscular administration of GlcNAc in rabbits with experimental knee OA did not show chondroprotective effects but showed mild anti-inflammatory activity. In contrast, intra-articular administration of GlcNAc twice a week reduced cartilage degradation. Additionally, intra-articular GlcNAc also suppressed synovitis. Once a week intra-articular injections of GlcNAc did not demonstrate therapeutic efficacy. The chondroprotective efficacy of GlcNAc was better than that of viscosupplementation treatment with hyaluronan. Conclusion: Intra-articular GlcNAc has chondroprotective and anti-inflammatory activity in experimental OA.

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Section: Discussionmentioning

confidence: 99%

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Shikhman

2005

Annals of the Rheumatic Diseases

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“…The remaining 8 animals were implanted with donor menisci – allografts. The medial meniscus was implanted according to a modified technique of Sommerlath and Gillquist [36]. After each procedure, antibiotic (enrofloxacin) was administered for prophylactic purposes at an intramuscular dose of 10 mg/kg b.w.…”

Section: Methodsmentioning

confidence: 99%

Experimental research Assessment of apoptosis and MMP-1, MMP-3 and TIMP-2 expression in tibial hyaline cartilage after viable medial meniscus transplantation in the rabbit

Zwierzchowski¹,

Stasikowska-Kanicka²,

Danilewicz³

et al. 2012

aoms

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IntroductionThe porpuse of this animal study was to assess chondrocyte apoptosis and MMP-1, MMP-3 and TIMP-2 expression in rabbit tibial cartilage 6 months after viable medial meniscal autografts and allografts.Material and methodsTwenty white male New Zealand rabbits were chosen for the study. The medial meniscus was excised from 14 animals and stored under tissue culture conditions for 2 weeks, following which t of them were implantated as autografts and 7 as allografts. The control group consisted of 6 animals which underwent arthtrotomy. When the animals were eutanized, the tibial cartilage was used for immunohisochemical examination. Apoptosis (TUNEL method) and MMP-1, MMP-3 and TIMP-2 expression were estimated semiquantatively.ResultsAn increased level of chodrocyte apoptosis in the tibail cartilage was observed after both kinds of transplants (p < 0.05), allografts (1.43 ±0.98) and autografts (0.86 ±0.69); no statistical diferences existed between them. An increased level of metalloproteinases and TIMP-2 expression was obreved only after allografts with statistical differences among the allograft group, the autograft group nad the control group (p < 0.05).ConclusionsOur findings suggest that the meniscal graft does not protect the hyaline cartilage against excessive apoptosis. The results of experimantal studies on humans indicate the need to device a method of apoptosis inhibition in the hyaline cartilage to improve long-term results of meniscal transplantation.

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“…Tissue engineering approaches assist sport engineering problems because it has been proved one of the most promising alternative therapies for soft tissue defects (Iwasa, Engebretsen, Shima, & Ochi, 2009;Lee, Grodzinsky, Hsu, & Spector, 2003;Sherwood et al, 2002).The compressive strength and stiffness of scaffolds in soft tissue engineering plays an important role in successfulness of tissue engineering ultimate goal . In this strategy, various scaffolds have been prepared from naturally derived and/or biodegradable synthetic polymers (Bi et al, 2011;Buma, Ramrattan, van Tienen, & Veth, 2004;Freymann et al, 2011;Heijkants et al, 2004;Klompmaker et al, 1993;Lien, Li, & Huang, 2008;Mandal, Park, Gil, & Kaplan, 2011;Nettles, Elder, & Gilbert, 2002;Sherwood et al, 2002;Sommerlath & Gillquist, 1993;Xia et al, 2004;Yan et al, 2010Yan et al, , 2011Wang et al, 2010). A wide range of polymers is limited by the lack of suitable mechanical properties, degradation behavior, controlled porosity and biocompatibility (Chiono et al, 2008;Thein-Han, Saikhun, Pholpramoo, Misra, & Kitiyanant, 2009;Xia et al, 2004) because of that finding the most adequate materials are essential.…”

Section: Introductionmentioning

confidence: 99%

How can genipin assist gelatin/carbohydrate chitosan scaffolds to act as replacements of load-bearing soft tissues?

Sarem

Moztarzadeh

Mozafari

2013

Carbohydrate Polymers

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The Effects of an Artificial Meniscus Substitute in a Knee Joint With a Resected Anterior Cruciate Ligament

Cited by 20 publications

References 0 publications

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis

Experimental research Assessment of apoptosis and MMP-1, MMP-3 and TIMP-2 expression in tibial hyaline cartilage after viable medial meniscus transplantation in the rabbit

How can genipin assist gelatin/carbohydrate chitosan scaffolds to act as replacements of load-bearing soft tissues?

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