The Effects of Anesthetic Preconditioning with Sevoflurane in an Experimental Lung Autotransplant Model in Pigs

Casanova, Javier; Garutti, Ignacio; Simón-Adiego, Carlos María; Giráldez, Ana María Chocrón; Martín, Beatriz; Gonzalez, Guillermo; Azcárate, Leire; Garcı́a, Cruz; Vara, Elena

doi:10.1213/ane.0b013e3182288e01

Cited by 55 publications

(40 citation statements)

References 29 publications

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“…4), which are pro-inflammatory, pro-fibrogenic and pro-angiogenic mediators. These findings are consistent with previous studies in which volatile anaesthetics reduced TNF-a [15][16][17][18][19][20][21], exerting antiinflammatory and organ-protective effects in ARDS models, even after a brief exposure [19]. The immunomodulatory effects of sevoflurane may be attributable to several mechanisms: (1) inhibition of synaptic transmission by activation of type-A gamma-aminobutyric acid (GABA A ) receptors in neurons [40], lung airways and alveolar cells [41], thus improving oxygenation and attenuating lung inflammation [15]; (2) reduction in TNF-a-induced endothelial permeability [42]; and (3) inhibition of TNF-a expression and inflammatory cytokine production through intracellular pathways [43].…”

Section: Discussionsupporting

confidence: 93%

“…5). Likewise, very recently, Casanova et al reported that sevoflurane preconditioning inhibited oxidative stress and pro-inflammatory responses in pigs subjected to an ischaemia-reperfusion lung injury protocol [16].…”

Section: Discussionmentioning

confidence: 95%

“…Some case reports have described a beneficial action of anaesthetics in refractory asthma [12][13][14], and studies have demonstrated their anti-inflammatory effects in experimental [15][16][17][18][19] and clinical [20,21] acute respiratory distress syndrome (ARDS) protocols. We have previously reported that sevoflurane promoted bronchodilation and reduced atelectasis in experimental allergic asthma [22].…”

Section: Introductionmentioning

confidence: 99%

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Effects of inhalational anaesthetics in experimental allergic asthma

et al. 2014

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SummaryWe evaluated whether isoflurane, halothane and sevoflurane attenuate the inflammatory response and improve lung morphofunction in experimental asthma. Fifty-six BALB/c mice were sensitised and challenged with ovalbumin and anaesthetised with isoflurane, halothane, sevoflurane or pentobarbital sodium for one hour. Lung mechanics and histology were evaluated. Gene expression of pro-inflammatory (tumour necrosis factor-a), pro-fibrogenic (transforming growth factor-b) and pro-angiogenic (vascular endothelial growth factor) mediators, as well as oxidative process modulators, were analysed. These modulators included nuclear factor erythroid-2 related factor 2, sirtuin, catalase and glutathione peroxidase. Isoflurane, halothane and sevoflurane reduced airway resistance, static lung elastance and atelectasis when compared with pentobarbital sodium. Sevoflurane minimised bronchoconstriction and cell infiltration, and decreased tumour necrosis factor-a, transforming growth factor-b, vascular endothelial growth factor, sirtuin, catalase and glutathione peroxidase, while increasing nuclear factor erythroid-2-related factor 2 expression. Sevoflurane down-regulated inflammatory, fibrogenic and angiogenic mediators, and modulated oxidant-antioxidant imbalance, improving lung function in this model of asthma.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Effects of inhalational anaesthetics in experimental allergic asthma

et al. 2014

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“…The anaesthetic procedure has been previously described [4,5]. Briefly, the anaesthetic premedication was performed with IM ketamine (10 mg/kg; Ketolar, Parke Davis, Pfizer, Dublin, Ireland).…”

Section: Anaesthesiamentioning

confidence: 99%

Chemokine Involvement in Lung Injury Secondary to Ischaemia/Reperfusion

Rancán

Paredes

Huerta

et al. 2017

Lung

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“…The content of each syringe and infusion was administered blind. More detailed descriptions of the anaesthetic [7] and surgical [22,23] …”

Section: Animal Model and Study Groupsmentioning

confidence: 99%

Glycocalyx Degradation after Pulmonary Transplantation Surgery

et al. 2018

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Purpose: Ischaemia-reperfusion injury (IRI) is a main cause of morbidity after pulmonary resection surgery. The degradation of glycocalyx, a dynamic layer of macromolecules at the luminal surface of the endothelium, seems to participate in tissue dysfunction after IRI. Lidocaine has a proven anti-inflammatory activity in several tissues but its modulation of glycocalyx has not been investigated. This work aimed to investigate the potential involvement of glycocalyx in lung IRI in a lung auto-transplantation model and the possible effect of lidocaine in modulating IRI. Methods: Three groups (sham-operated, control, and lidocaine), each consisting of 6 Large White pigs, were subjected to lung auto-transplantation. All groups received the same anaesthesia. In addition, the lidocaine group received a continuous IV administration of lidocaine (1.5 mg/kg/h). Lung tissue and plasma samples were taken before pulmonary artery clamp, before reperfusion, and 30 and 60 min post-reperfusion in order to analyse pulmonary oedema, glycocalyx components, adhesion molecules, and myeloperoxidase level. Results: Ischaemia caused pulmonary oedema, which was greater after reperfusion. This effect was accompanied by decreased levels of syndecan-1 and heparan sulphate in the lung samples, together with increased levels of both glycocalyx components in the plasma samples. After reperfusion, neutrophil activation and the expression of adhesion molecules were increased. All these alterations were significantly lower or absent in the lidocaine group. Conclusion: Lung IRI caused glycocalyx degradation that contributed to neutrophil activation and adhesion. The administration of lidocaine was able to protect the lung from glycocalyx degradation.

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The Effects of Anesthetic Preconditioning with Sevoflurane in an Experimental Lung Autotransplant Model in Pigs

Cited by 55 publications

References 29 publications

Effects of inhalational anaesthetics in experimental allergic asthma

Effects of inhalational anaesthetics in experimental allergic asthma

Chemokine Involvement in Lung Injury Secondary to Ischaemia/Reperfusion

Glycocalyx Degradation after Pulmonary Transplantation Surgery

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