The Effects of Antiasthmatic Drugs against Immune Complex-Induced Bronchoconstriction in Anesthetized Dogs

Mielens, Z.E.

doi:10.1159/000137271

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…The procedure was the same as described previously [Mielens, 1979] except for minor modifications. Briefly, mongrel dogs were anesthetized and artificially respired, lntra-tracheal pressure (ITP).…”

Section: Inhibition O F Histamine-induced Increase M Intra-tracheal Pmentioning

confidence: 99%

Relaxant Effects of Amrinone upon Pulmonary Smooth Muscle

Mielens¹,

Buck²

1982

Pharmacology

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Amrinone, a cardiac positive inotropic agent, inhibited histamine-induced bronchoconstriction in a dose-related manner in dogs when administered intra-duodenally at doses ranging from 0.3 to 10 mg/kg. This bronchodilatory property of amrinone in vivo was confirmed in vitro: amrinone relaxed carbachol-induced contractions and it inhibited Ba²⁺- or histamine-induced contractions of guinea pig tracheas. When amrinone was examined for its inhibition of histamine contractions under modified Ca²⁺ availability, the EC25 and EC₇₅ of amrinone were 76 and 8 times smaller, respectively, under conditions of intracellular rather than normal Ca²⁺ availability. The corresponding decreases for verapamil were 12,414 and 33 times. No meaningful changes in the potencies of amrinone or verapamil were seen when normal Ca²⁺ availability was changed to extracellular Ca²⁺ availability. These data suggest that verapamil, and partially amrinone, inhibit histamine-induced tracheal contractions by reducing the bioavailability of intracellular Ca²⁺.

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Section: Inhibition O F Histamine-induced Increase M Intra-tracheal Pmentioning

confidence: 99%

Relaxant Effects of Amrinone upon Pulmonary Smooth Muscle

Mielens¹,

Buck²

1982

Pharmacology

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Bitolterol Mesylate: A Beta‐adrenergic Agent; Chemistry, Pharmacokinetics, Pharmacodynamics, Adverse Effects and Clinical Efficacy in Asthma

1985

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Bitolterol, (3-4 diester colterol) is a new beta 2-adrenergic agonist. Since it in itself is biologically inactive, bitolterol is considered a pro-drug. When administered it is activated within the lung by esterase hydrolysis to the active compound colterol catecholamine N-t-butyl-arterenol). In preclinical and clinical studies to date, bitolterol has proved to be an effective bronchodilator for adult and pediatric patients with chronic stable asthma and for some with chronic obstructive pulmonary disease. Bitolterol has been compared with other beta 2 agents, including isoproterenol, metaproterenol and albuterol. There is no evidence for cardiotoxicity when bitolterol is used in combination with theophylline in human studies. It is effective for control of exercise-induced asthma.

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Pharmacologic characterization of immune complex induced bronchoconstriction in guinea pigs

1981

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Intravenous injections of soluble immune complexes to anesthetized guinea pigs resulted in bronchoconstriction that was inhibited by FPL 55712, indomethacin, oxarbazole, soybean trypsin inhibitor, and cobra venom factor. Immune complex induced bronchoconstriction was not inhibited by atropine, imidazole, mepyramine, ketotifen, methysergide, and the anti-anaphylactic compound DPP (Diethyl [2-(4-pyridyl)-4-pyrimidinyl]aminoethylene malonate). Immune complex induced bronchoconstriction in guinea pigs appears to involve activation of complement and formation of anaphylatoxins. In addition, products of cyclo-oxygenase metabolism of arachidonic acid and kinins may be involved.

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The Effects of Antiasthmatic Drugs against Immune Complex-Induced Bronchoconstriction in Anesthetized Dogs

Cited by 5 publications

References 9 publications

Relaxant Effects of Amrinone upon Pulmonary Smooth Muscle

Relaxant Effects of Amrinone upon Pulmonary Smooth Muscle

Bitolterol Mesylate: A Beta‐adrenergic Agent; Chemistry, Pharmacokinetics, Pharmacodynamics, Adverse Effects and Clinical Efficacy in Asthma

Pharmacologic characterization of immune complex induced bronchoconstriction in guinea pigs

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