The Effects of Antidepressants Taken With and Without Alcohol on Psychomotor Performance and Car Handling Ability

Hindmarch, Ian; Subhan, Z.

doi:10.1097/00002826-198406001-00071

Cited by 20 publications

(30 citation statements)

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“…Fengabine had a neutral effect throughout the test battery. Due to the fact that the detrimental effects of amitriptyline have been well documented (Hanks, 1984;Hindmarch et al, 1983Hindmarch et al, , 1988Hindmarch & Subhan, 1986) and that these tests have previously been shown to be valid and reliable indicators of drug effects (Hindmarch et al, 1990b(Hindmarch et al, , 1991, it can be concluded that, as fengabine 200 mg and 400 mg has no significant effect on the test battery when compared to placebo, it has very low potential for behavioural toxicity in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

A placebo controlled double‐blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers.

Fairweather

Kerr

Hilton

et al. 1993

Brit J Clinical Pharma

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GU7 lUF and 2Synthelabo Recherche (LERS), 9 John Street, London WC1N 2ES1 The effects of fengabine were compared with those of amitriptyline in healthy elderly volunteers. Doses were administered double-blind and assessments were made before and after ingestion. 2 Psychomotor performance and cognitive ability were measured using tests of choice reaction time, tracking, critical flicker fusion threshold, memory scanning and word recognition. Subjective feelings were assessed using the Leeds sleep evaluation questionnaire (LSEQ) and line analogue rating scales (LARS). 3 Pharmacokinetic data suggest that fengabine may induce its own metabolism following repeated dosing. 4 The findings of this study show that fengabine 200 mg and 400 mg does not produce any noticeable behavioural toxicity in elderly volunteers, in contrast to amitriptyline which had a disruptive effect throughout.

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Section: Discussionmentioning

confidence: 99%

A placebo controlled double‐blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers.

Fairweather

Kerr

Hilton

et al. 1993

Brit J Clinical Pharma

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“…Impairment of psychomotor function on antidepressant drugs other than MAOIs is very well documented (Hindmarch, 1980(Hindmarch, , 1988Hindmarch & Subhan, 1986). Doses given in therapeutics and administered to healthy subjects lead to substantial deterioration of vigilance and/or memory functions (Bye et al, 1978;Curran et al, 1986;Seppala & Linnoila, 1983).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase‐A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

Berlin

Zimmer

et al. 1990

Brit J Clinical Pharma

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1 The effects of two reversible, predominantly monoamine oxidase-A (MAO-A) inhibitors, moclobemide (150 mg three times daily) and toloxatone (400-200-400 mg day-1) on monoamine metabolites and psychometric performance were compared in a double-blind placebo controlled crossover study in 12 healthy subjects. 2 After 7 days of moclobemide/toloxatone/placebo administration subjects were hospitalized for 24 h on day 8. Blood samples were drawn every 2 h for determination of plasma noradrenaline (NA), 3,4-dihydroxyphenylglycol (DHPG), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA). Urine was collected for measurements of normetanephrine and 3-methoxytyramine excretion. Psychometric performance (short-and long-term memory, critical flicker fusion frequency, choice reaction time) and subjective feelings were assessed before each drug intake (in the morning, at noon, in the evening). 3 Compared with placebo, both reversible monoamine oxidase inhibitors decreased the plasma concentration of DHPG and HVA. The overall fall in DHPG (AUC from 0 to 24 h) was 44% during moclobemide and 12% during toloxatone (P < 0.001) and the overall decrease in HVA was 38% and 20% (P < 0.005) on moclobemide and toloxatone, respectively. 4 Before the next drug intake, MAO-A inhibition, as judged by the decrease of plasma DHPG concentration, was significantly different from placebo with moclobemide but not with toloxatone. 5 Moclobemide, but not toloxatone, exerted a moderate, but significant inhibition of the deamination of 5-hydroxytryptamine (5-HT) as judged by the fall in plasma 5-HIAA concentration. Neither drug influenced plasma NA concentration. 6 A significant rise in urinary excretion of normetanephrine was observed on moclobemide and to a lesser extent on toloxatone. The urinary excretion of 3-methoxytyramine was significantly raised by moclobemide but not by toloxatone. 7 Neither moclobemide nor toloxatone altered memory function, vigilance, subjective feelings or sleep characteristics of the subjects.

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“…Whereas the psychometric methods so far described measure relatively simple sensory and psychomotor func tions, Hindmarch et al [12,13] stress the importance of multidimensional complex experimental setups which are needed for examination of drug effects on daily activities such as car driving for reasons of environmental validity. Such setups as a rule consist of a driving simulator (CAR) in which different complex coordination jobs must be done the individual components of which are derived from the above described methods.…”

Section: Psychometric Methods For Evaluating the Side Effect Profile mentioning

confidence: 99%

Antidepressant Drugs and Psychomotor Performance

Volz¹,

Sturm²

1995

Neuropsychobiology

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Nearly all antidepressants are tested psychometrically in order to detect side effects of these drugs. Based on a review of the relevant published data on critical flicker fusion frequency measurements, simple reaction time, complex reaction time, tracking, tapping, and car driving simulation measurements, the underlying principles of the different effects of these drugs in healthy volunteers are discussed. It seems that essentially the sedative properties of a compound are important rather than e.g. specific reuptake inhibiting properties or the chemical structure. This finding is discussed in the light of the usefulness of these test procedures for detecting side effects.

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The Effects of Antidepressants Taken With and Without Alcohol on Psychomotor Performance and Car Handling Ability

Cited by 20 publications

References 0 publications

A placebo controlled double‐blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers.

A placebo controlled double‐blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers.

Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase‐A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects.

Antidepressant Drugs and Psychomotor Performance

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