The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism

Khutami, Chindiana; Sumiwi, Sri Adi; Ikram, Nur Kusaira Khairul; Muchtaridi, Muchtaridi

doi:10.3390/ijms23042056

Cited by 49 publications

(25 citation statements)

References 131 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, there is no approved treatment available for NAFLD. Medicinal herbs with high phenolic content have been explored as a safe and convenient treatment option for NAFLD, as they are known to have beneficial anti-inflammatory and antifibrogenic activity, and antioxidant effects, and can suppress hepatic lipid accumulation [ 17 ]. The current study showed strong evidence of the anti-steatotic effect of O. aristatus by using HFD-fed mice and a palmitic–oleic acid-induced model of NAFLD in HepG2 cells.…”

Section: Discussionmentioning

confidence: 99%

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

et al. 2023

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of liver disease. Orthosiphon aristatus (Blume) Miq, a traditional plant in South Asia, has previously been shown to attenuate obesity and hyperglycaemic conditions. Eight weeks of feeding C57BL/6 mice with the standardized O. aristatus extract (400 mg/kg) inhibited the progression of NAFLD. Liver enzymes including alanine aminotransferase and aspartate transaminase were significantly reduced in treated mice by 74.2% ± 7.69 and 52.8% ± 7.83, respectively. Furthermore, the treated mice showed a reduction in serum levels of glucose (50% ± 5.71), insulin (70.2% ± 12.09), total cholesterol (27.5% ± 15.93), triglycerides (63.2% ± 16.5), low-density lipoprotein (62.5% ± 4.93) and atherogenic risk index relative to the negative control. Histologically, O. aristatus reversed hepatic fat accumulation and reduced NAFLD severity. Notably, our results showed the antioxidant activity of O. aristatus via increased superoxide dismutase activity and a reduction of hepatic malondialdehyde levels. In addition, the levels of serum pro-inflammatory mediators (IL-6 and TNFα) decreased, indicating anti-inflammatory activity. The aqueous, hydroethanolic and ethanolic fractions of O. aristatus extract significantly reduced intracellular fat accumulation in HepG2 cells that were treated with palmitic–oleic acid. Together, these findings suggest that antioxidant activities are the primary mechanism of action of O. aristatus underlying the anti-NAFLD effects.

show abstract

Section: Discussionmentioning

confidence: 99%

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Antioxidants have a crucial role in the prevention and treatment of atherosclerosis through different mechanisms: the inhibition of LDL oxidation, the reduction of reactive oxygen species (ROS) generation, the prevention of atherosclerotic plaque formation and platelet aggregation, improvement of endothelial dysfunction, and vasodilation, the augmentation of NO bioavailability, and suppression of foam cell formation. 26,27 NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of lipid peroxidation, inhibition of leukocyte chemotaxis, and platelet adhesion, which are important mechanisms in the prevention of atherosclerosis. 28,29 Besides, CoQ10, curcumin, resveratrol, quercetin, and berberine have an effect on regulating dyslipidemia via different mechanisms and contribute to the anti-atherosclerotic effect of Nano NO plus.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Effect of Nano NO Plus Capsules on Hypertensive and Atherosclerotic rat Models

Nguyen

Luu

Nguyen

et al. 2022

Natural Product Communications

View full text Add to dashboard Cite

Hypertension is a significant public health issue that is increasing in prevalence and can have dangerous complications. This atherosclerotic disease occurs due to lifestyle choices, such as being sedentary, eating fast foods, and a lack of physical exercise. Atherosclerosis has gradually become the leading cause of death worldwide. Currently, the trend of using natural products to supplement and replace synthetic drugs is being considered in many places. This study evaluated the antihypertensive and anti-atherosclerosis effects of Nano NO plus capsules on hypertensive and atherosclerotic rat models. The results showed that Nano NO plus given to rats at doses of 420 mg/kg and 840 mg/kg lowered systolic, diastolic, and average blood pressure (BP) without affecting heart rate. Nano NO plus capsules also increased nitric oxide (NO), superoxide dismutase (SOD), glutathione (GSH), and decreased malondialdehyde (MDA) in the rats’ plasma. All of these effects were comparable to those of Losartan at 25 mg/kg. Furthermore, doses of 420 mg/kg and 840 mg/kg reduced blood lipid test indexes, including triglyceride (TG) levels, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and atherogenic index (AI). At the same time, Nano NO plus capsules increased the levels of high-density lipoprotein-cholesterol (HDL-C) in the blood and protected against atherosclerotic lesions of the abdominal aorta in the studied rats. These results indicate that Nano NO plus is a potential product to treat hypertension and atherosclerotic.

show abstract

“…Consequently, it represents enormous socio-economic and negative impacts on patient's social and psychological attitude. [2][3][4][5][6] Currently, several therapeutic plans are implemented for the treatment and/or prevention of obesity including lifestyle, nutrition education, and anti-obesity medications. 7,8 However, it is reported that weight management through physical exercises are not sufficient to produce marked treatment.…”

Section: Introductionmentioning

confidence: 99%

Cichorioside a biocoumarin modulates lipid and glucose storage on 3T3-L1 cell lines: In vitro and in silico approach

Alqahtani¹,

Alsuliman²,

Alasoom³

et al. 2023

Pharmacogn J.

View full text Add to dashboard Cite

Natural coumarins are reputed to demonstrate several biological effects to improve adverse health conditions including; obesity. This study was conducted to explore the potential in vitro lipid and glucose modulatory activity of cichorioside on 3T3-L1 cell lines . Methods: The 3T3-L1 cell lines were cultured and cell viability was assessed. Glucose content in medium of cultured cells was measured. Differentiation of 3T3-L1 cells from pre-adipocytes to adipocytes was evaluated upon addition of cichorioside. Expression of mRNA of the peroxisome proliferator-activated receptor gamma (PPARγ) was estimated. Results: Survival of around 90% of cultured cells was observed at 10μM cichorioside. Cichorioside inhibited glucose uptake from the medium by the 3T3-L1 cell lines. Cichorioside considerably inhibited pre-adipocyte differentiation and the lipid content in intercellular storage. Cichorioside demonstrated an upregulation of the mRNA expression of PPARγ. Moreover, the docking studies supported the results via the deep interaction of cichorioside with amino acids residue of PPAR-γ. Taken together, these findings are the first report on in vitro evaluation of cichorioside to modulate the lipid storage and glucose uptake of cultured 3T3-L1 cell lines.

show abstract

The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism

Cited by 49 publications

References 131 publications

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

Orthosiphon aristatus (Blume) Miq Alleviates Non-Alcoholic Fatty Liver Disease via Antioxidant Activities in C57BL/6 Obese Mice and Palmitic–Oleic Acid-Induced Steatosis in HepG2 Cells

In Vivo Effect of Nano NO Plus Capsules on Hypertensive and Atherosclerotic rat Models

Cichorioside a biocoumarin modulates lipid and glucose storage on 3T3-L1 cell lines: In vitro and in silico approach

Contact Info

Product

Resources

About