Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, the treatment requires many drugs. Antioxidant compounds have been reported to have activities against obesity, dyslipidemia and diabetes via several mechanisms. This review aims to discuss the antioxidant compounds that have activity against obesity, dyslipidemia and diabetes together with their molecular signaling mechanism. The literature discussed in this review was obtained from the PUBMED database. Based on the collection of literature obtained, antioxidant compounds having activity against the three disorders (obesity, dyslipidemia and diabetes) were identified. The activity is supported by various molecular signaling pathways that are influenced by these antioxidant compounds, further study of which would be useful in predicting drug targets for a more optimal effect. This review provides insights on utilizing one of these antioxidant compounds as opposed to several drugs. It is hoped that in the future, the number of drugs in treating obesity, dyslipidemia and diabetes altogether can be minimized consequently reducing the risk of side effects.

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Obesity is a disease caused by an imbalance of food intake with the energy expended. While dyslipidemia is a complication of lipid disease in the body that can trigger various complications such as cardiovascular disease. Research on antiobesity and antidislipidemia has been done to obtain compounds that can overcome obesity and dyslipidemia because synthetic drugs that have been traded in the community still cause many adverse side effects, one of which is research from the genus Garcinia species. The method for finding reference sources in this review used “Pubmed” database with the keywords "Antiobesity of garcinia", “Antihyperlipidemic OR obesity AND garcinia” and “Obesity OR dyslipidemic AND garcinia”. From the inclusion results, 19 journal articles were discussed in this review. Based on the review results from these reference sources, 9 species of the genus garcinia have activity as antiobesity and antidyslipidemia, namely G. mangostana, G. atroviridis, G. pedunculata, G. dulcis, G. gummi gutta, G. cambogia, G. brasiliensis, G. indica and G. kola.