The effects of apigenin‐7‐O‐β‐d‐glucuronopyranoside on reflux oesophagitis and gastritis in rats

Abstract

1. This study evaluated the inhibitory action of apigenin-7-O-beta-D-glucuronopyranoside (AGC), apigenin, and omeprazole on reflux oesophagitis and gastritis in rats. AGC was isolated from Clerodendron trichotomum leaves. 2. Oesophagitis and gastritis were induced by surgical procedure and the administration of indomethacin, respectively. The intraduodenal (i.d.) administration of AGC decreased the volume of gastric juice and increased the gastric pH compared with apigenin and omeprazole. The acid output was more inhibited by AGC in a dose-dependent manner than by apigenin and omeprazole. Compared with apigenin and omeprazole, AGC significantly decreased the size of gastric lesions, which were induced by exposure of the gastric mucosa to indomethacin. 3. Malondialdehyde (MDA) content, which is the end product of lipid peroxidation, was increased significantly after the induction of reflux oesophagitis. The MDA content was decreased by AGC (i.d. 3 mg kg(-1)), but not by either apigenin or omeprazole. This suggests that AGC has an antioxidative effect. In the oesophagitis group, the mucosal levels of glutathione (GSH) were significantly lower than that in the normal group. However, the GSH levels were preserved after administering the AGC, suggesting that AGC possesses scavenging activity. 4. In summary, AGC is more potent than apigenin and omeprazole at inhibiting reflux oesophagitis and gastritis and may therefore be a promising drug for their treatment.

Gastrin-Releasing Peptide Receptor Antagonist or N-acetylcysteine combined with Omeprazol Protect against Mitochondrial Complex II Inhibition in a Rat Model of Gastritis

“…Stress, ethanol, bile and avoidance of steroidal anti-inflammatory drugs (NSAIDs) disrupt the gastric mucosal barrier, making it vulnerable to normal gastric secretions [3,4,5].…”

The Inhibitory Effect of Quercetin-3-O-β-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

“…In fact, mainstay of medical treatment is the suppression of gastric acid secretion (Bell et al, 1992;Wolfe et al, 2000). In a previous study, we showed that apigenin-and luteolin-contained flavonoids have a beneficial effect on esophagitis and gastritis in rats (Min et al, 2005), and the findings of the present study suggest that QGC has an inhibitory effect on reflux esophagitis and indomethacin-induced gastritis, and that these inhibitions are caused by reductions in gastric secretions and oxidative stress. In addition, our findings support the antiulcer, gastroprotective, and gastric antisecretory effects of QGC and quercetin.…”

GC-MS Analysis of Young Leaves of Allophylus cobbe (L.) Raeusch. and Allophylus serratus (Roxb.) Kurz.

“…An abundant presence of phytol in leaves of Allophylus species suggests that these species may prove helpful in prevention of degenerative diseases. Phytol is used in A. serratus Phenacetamide Leaves antiulcer [10] β-Sitosterol Leaves antiulcer [10] Rutin Leaves antiosteoporotic [11] hepatoprotective [51] radical scavenger [52] Quercetin Leaves hepatoprotective [51] anti-inflammatory, analgesic, aniti-cancer [53] tyrosinase kinase inhibitor [54] Pinitol Leaves [11] hepatoprotective [55] Anti-cancer [56] Anti-diabetic [57] Luteolin-7-O-β-D-glucopyranoside Leaves [11] Inhibits cell apoptosis [58] Apigenin-4'-O-β -D-glucoside Leaves [11] against reflux oesophagitis gastritis [59] (Adapted from: Chavan and Gaikwad, 2016)…”