The Effects of Ascorbic Acid on the Estrogen/Progesteron Levels in the Isolated Rabbit Uterine Muscle

Abstract

Background: The study was carried out to examine the effect of Ascorbic Acid (AsA) on estrogen/progesterone levels in the isolated non-pregnant rabbit uterine muscle.

Hormonal Changes in Relation to Productivity of Pregnant Rabbit Does.

“…The current level is ranged between 47.3 to 89.0 pg/ml during the second half of pregnancy days. This level is slightly lower than that (98.1 pg/ml) found by Bostanci et al (2012). Conversely, our present level is much higher than other studies.…”

“…Additionally, the present data disagree and lower than those of Alfonso (2016) who found that, the highest level (12 ng/ml) of P4 was at day 14 of pregnancy, after that its level started to decrease at days 21 and 28 of pregnancy (10 and 8 ng/ml, respectively). On the other side, it is much higher than that (1.5 ng/ml) obtained by Bostanci et al (2012). Generally, the level of P4 hormone in rabbits during pregnancy is lower than that in other species, Neville et al (2002) stated that P4 in rat is ranged between 6-130 ng/ml, and reaching to 200 ng/ml in human.…”

“…Both P4 and E2 have synergistic relationship, as confirmed in the present study by their positive correlation (+0.69; P<0.05), because during the second half of rabbit pregnancy the luteal P4 synthesis is dependent upon the E2 level. This means that E2 is considered a vital factor in maintaining P4 level during gestation period (Bostanci et al, 2012). Furthermore, Neville et al (2002) found that, E2 stimulates P4 receptors in the luminal epithelial cells of MG.…”

“…However, it has negative impact on milk production, because E2 accelerate MG involution. In the same context, Bostanci et al (2012) mentioned that both P4 and E2 are important in maintaining uterine via regulation of blood flow and synthesis of cell surface receptors. Additionally, they cleared that E2 may indirectly influences the antioxidant system, thereby reducing the free radicals that caused oxidative stress, but the way of interacting of E2 and the antioxidant system is not yet clear.…”

PHARMACOLOGICAL MANAGEMENT OF MENOPAUSAL DISORDERS: THE PHYTOESTROGENES (review)

“…Про це свідчить позитивний клінічний досвід застосування монокомпонентних вагінальних супозиторіїв з молочною кислотою «Фемілекс» [67]. За даними дослідників введення до складу таких препаратів аскорбінової кислоти може не тільки сприяти збереженню вагінального біотопу, але й підвищувати вміст естрогенів у тканинах генітального тракту [68]. Наявність антиоксидантних властивостей може бути корисним для відновлення про/антиоксидантного балансу, яке виникає внаслідок дефіциту естрогенів.…”